A regulatory role for cytoplasmic YVKM motif in CTLA‐4 inhibition of TCR signaling

No abstract is available for this paper.

• Publication year

  2001

• Venue

  European Journal of Immunology

• Publication date

  2001-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/1521-4141(200107)31:7<2042::AID-IMMU2042>3.0.CO;2-DPMID 11449357
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• TGF-β Mediates CTLA-4 Suppression of Cellular Immunity in Murine Kalaazar1

  2000cited by this paper
• Structural Analysis of CTLA-4 Function In Vivo1

  2000cited by this paper
• Tyrosine phosphatase SHP-2 binding to CTLA-4: absence of direct YVKM/YFIP motif recognition.

  2000cited by this paper
• TGF-beta mediates CTLA-4 suppression of cellular immunity in murine kalaazar.

  2000cited by this paper
• The Inhibitory Function of CTLA-4 Does Not Require Its Tyrosine Phosphorylation1

  2000cited by this paper
• Involvement of hepatic nuclear factor I binding motif in transcriptional regulation of Ca(2+)-binding protein regucalcin gene.

  2000cited by this paper
• Cutting Edge: Tyrosine-Independent Transmission of Inhibitory Signals by CTLA-41

  2000cited by this paper
• The CD28-related molecule ICOS is required for effective T cell-dependent immune responses.

  2000cited by this paper
• Regulation of cytotoxic T lymphocyte-associated molecule-4 by Src kinases.

  1999cited by this paper
• Cytolytic T lymphocyte-associated antigen-4 and the TCR zeta/CD3 complex, but not CD28, interact with clathrin adaptor complexes AP-1 and AP-2.

  1999cited by this paper
• CTLA-4-Mediated inhibition of early events of T cell proliferation.

  1999cited by this paper
• Cytotoxic T Lymphocyte Antigen 4 (Ctla-4) Engagement Delivers an Inhibitory Signal through the Membrane-Proximal Region in the Absence of the Tyrosine Motif in the Cytoplasmic Tail

  1999cited by this paper
• Involvement of SHP-2 in multiple aspects of IL-2 signaling: evidence for a positive regulatory role.

  1998cited by this paper
• The Phosphotyrosine Phosphatase SHP-2 Participates in a Multimeric Signaling Complex and Regulates T Cell Receptor (TCR) coupling to the Ras/Mitogen-activated Protein Kinase (MAPK) Pathway in Jurkat T Cells

  1998cited by this paper
• Binding of Shp2 Tyrosine Phosphatase to FRS2 Is Essential for Fibroblast Growth Factor-Induced PC12 Cell Differentiation

  1998cited by this paper
• Molecular basis of T cell inactivation by CTLA-4.

  1998cited by this paper
• Cytotoxic T Lymphocyte Antigen 4 Is Induced in the Thymus upon In Vivo Activation and Its Blockade Prevents Anti-CD3–mediated Depletion of  Thymocytes

  1998cited by this paper
• Resting lymphocyte kinase (Rlk/Txk) phosphorylates the YVKM motif and regulates PI 3-kinase binding to T-cell antigen CTLA-4.

  1998cited by this paper
• Src family tyrosine kinases associate with and phosphorylate CTLA-4 (CD152).

  1998cited by this paper
• Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein.

  1997cited by this paper
• Interaction of the cytoplasmic tail of CTLA-4 (CD152) with a clathrin-associated protein is negatively regulated by tyrosine phosphorylation.

  1997cited by this paper
• Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression.

  1997cited by this paper
• Wortmannin, a phosphatidylinositol 3-kinase inhibitor, blocks antigen-mediated, but not CD3 monoclonal antibody-induced, activation of murine CD4+ T cells.

  1997cited by this paper
• Regulatory interactions in the recognition of endocytic sorting signals by AP‐2 complexes

  1997cited by this paper
• Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2.

  1997cited by this paper
• Upstream-downstream: CD28 cosignaling pathways and T cell function.

  1996cited by this paper
• Regulation of T Cell Receptor Signaling by Tyrosine Phosphatase SYP Association with CTLA-4

  1996cited by this paper
• AP-2-containing clathrin coats assemble on mature lysosomes

  1996cited by this paper
• CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells

  1996cited by this paper
• Inhibition of phosphatidylinositol 3-kinase blocks T cell antigen receptor/CD3-induced activation of the mitogen-activated kinase Erk2.

  1996cited by this paper
• Upstream-downstream: CD28 cosignaling pathways and T cell function.

  1996cited by this paper
• CTLA-4 ligation blocks CD28-dependent T cell activation [published erratum appears in J Exp Med 1996 Jul 1;184(1):301]

  1996cited by this paper
• T-cell activation: integration of signals from the antigen receptor and costimulatory molecules.

  1995cited by this paper
• Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4.

  1995cited by this paper
• New perspectives of C1328-137-mediated T cell costimulation

  1995cited by this paper
• New perspectives of CD28-B7-mediated T cell costimulation.

  1995cited by this paper
• Selective CD28pYMNM mutations implicate phosphatidylinositol 3-kinase in CD86-CD28-mediated costimulation.

  1995cited by this paper
• Distinct roles for the costimulatory ligands B7-1 and B7-2 in T helper cell differentiation?

  1995cited by this paper
• CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation

  1995cited by this paper
• Distinct roles for CD28 and cytotoxic T lymphocyte-associated molecule- 4 receptors during T cell activation?

  1995cited by this paper
• CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells

  1995cited by this paper
• Cytotoxic T Lymphocyte-associated Molecule-4, a High Avidity Receptor for CD80 and CD86, Contains an Intracellular Localization Motif in Its Cytoplasmic Tail (*)

  1995cited by this paper
• p56^ and p59^ regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor binding protein GRB-2 and T cell specific kinase ITK: implications for T cell co-stimulation.

  1995cited by this paper
• Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4

  1995cited by this paper
• p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation.

  1995cited by this paper
• CTLA-4 can function as a negative regulator of T cell activation.

  1994cited by this paper
• T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif.

  1994cited by this paper
• Helper T-cell development in the absence of CD4-p56 Ick association

  1993cited by this paper

• Post-translational modifications of immune checkpoints: unlocking new potentials in cancer immunotherapy

  2025cites this paper
• The Role of the CD28 Family Receptors in T-Cell Immunomodulation

  2024cites this paper
• Unleashing the efficacy of immune checkpoint inhibitors for advanced hepatocellular carcinoma: factors, strategies, and ongoing trials

  2023cites this paper
• Immune Checkpoint Receptors Signaling in T Cells

  2022cites this paper
• Next generation of immune checkpoint molecules in maternal‐fetal immunity *

  2022cites this paper
• The fusion of quantitative molecular proteomics and immune‐oncology: a step towards precision medicine in cancer therapeutics

  2022cites this paper
• Motility Dynamics of T Cells in Tumor-Draining Lymph Nodes: A Rational Indicator of Antitumor Response and Immune Checkpoint Blockade

  2021cites this paper
• Molecular and Cellular Functions of CTLA-4.

  2020cites this paper
• Phosphorylation: A Fast Switch For Checkpoint Signaling.

  2020cites this paper
• Regulation of Cancer Immune Checkpoints: Molecular and Cellular Mechanisms and Therapy

  2020cites this paper
• Immunological Targets for Immunotherapy: Inhibitory T Cell Receptors.

  2019cites this paper
• CTLA-4 antibody ipilimumab negatively affects CD4+ T-cell responses in vitro

  2019cites this paper
• Immunotherapy of Cancer

  2017cites this paper
• Cellular and molecular events controlling acquisition of cytotoxic activity by melanoma-reactive CD4⁺ T cells in vivo

  2016cites this paper
• Histamine Stimulates Ciliary Beat Frequency via the H2 Receptor in the Protochordate Botryllus schlosseri.

  2016cites this paper
• Confusing signals: Recent progress in CTLA-4 biology

  2015cites this paper
• T Cell Co-inhibitory Receptors-Functions and Signalling Mechanisms

  2013cites this paper
• New therapies in the treatment of melanoma

  2012influential citation
• Evolving clinical profile of IL-1β, IL-10 and CTLA-4 gene in rheumatoid factor positive Caucasian population

  2011cites this paper
• 1) INVESTIGATION OF THE CLATHRIN-DEPENDENT INTERNALISATION OF CYTOTOXIC T LYMPHOCYTE ANTIGEN-4

  2011cites this paper
• Slow down and survive: Enigmatic immunoregulation by BTLA and HVEM.

  2010cites this paper
• SHP‐1 and SHP‐2 in T cells: two phosphatases functioning at many levels

  2009cites this paper
• CD28 and CTLA‐4 coreceptor expression and signal transduction

  2009cites this paper
• Transduction of the cytoplasmic domain of CTLA-4 inhibits TcR-specific activation signals and prevents collagen-induced arthritis

  2008cites this paper
• T-cell immune response cDNA 7 in allograft rejection and inflammation.

  2007cites this paper
• Specific and high-affinity binding of tetramerized PD-L1 extracellular domain to PD-1-expressing cells: possible application to enhance T cell function.

  2007cites this paper
• IMGT Colliers de Perles and IgSF domain standardization for T cell costimulatory activatory (CD28, ICOS) and inhibitory (CTLA4, PDCD1 and BTLA) receptors.

  2007influential citation
• B and T lymphocyte attenuator interacts with CD3ζ and inhibits tyrosine phosphorylation of TCRζ complex during T‐cell activation

  2007cites this paper
• TIRC7 Inhibits T Cell Proliferation by Modulation of CTLA-4 Expression

  2006cites this paper
• Intranasal delivery of the cytoplasmic domain of CTLA-4 using a novel protein transduction domain prevents allergic inflammation

  2006cites this paper
• Phosphotyrosine Motifs Cells That Can Be Initiated by Multiple Inhibitory Signal to Primary Human CD4 T Signal Transduction Provides a Potent B and T Lymphocyte Attenuator-Mediated

  2006cites this paper
• A molecular perspective of CTLA-4 function.

  2006cites this paper
• BTLA and HVEM cross talk regulates inhibition and costimulation.

  2006cites this paper
• SHP2 forecast for the immune system: fog gradually clearing.

  2006cites this paper
• B and T Lymphocyte Attenuator-Mediated Signal Transduction Provides a Potent Inhibitory Signal to Primary Human CD4 T Cells That Can Be Initiated by Multiple Phosphotyrosine Motifs

  2006cites this paper
• Balancing co-stimulation and inhibition with BTLA and HVEM

  2006cites this paper
• B and T Lymphocyte Attenuator-Mediated Signal Transduction Provides a Potent Inhibitory Signal to Primary Human CD4 T Cells That Can Be Initiated by Multiple Phosphotyrosine Motifs1

  2006cites this paper
• Regulation of the Small GTPase Rap1 and Extracellular Signal-Regulated Kinases by the Costimulatory Molecule CTLA-4

  2005cites this paper
• Tyrosine-mediated inhibitory signals contribute to CTLA-4 function in vivo.

  2004cites this paper
• Negative Regulation of T Cell Receptor–Lipid Raft Interaction by Cytotoxic T Lymphocyte–associated Antigen 4

  2003cites this paper
• Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling

  2003cites this paper
• CTLA-4 Suppresses Proximal TCR Signaling

  2002cites this paper
• A Potential Role for Tyrosine Phosphatases Phosphorylation : 319 Inhibiting ZAP-70 Tyr T Cells by + in Resting Human CD 4 CTLA-4 Suppresses Proximal TCR Signaling

  2002cites this paper
• CTLA-4 Suppresses Proximal TCR Signaling in Resting Human CD4+ T Cells by Inhibiting ZAP-70 Tyr319 Phosphorylation: A Potential Role for Tyrosine Phosphatases1

  2002cites this paper
• Phosphatidylinositol 3-Kinase p85 Adaptor Function in T-cells

  2002cites this paper