Computational model of cellular metabolic dynamics: effect of insulin on glucose disposal in human skeletal muscle.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  American Journal of Physiology. Endocrinology and Metabolism

• Publication date

  2010-06-01

• Fields of study

  Biology, Medicine, Computer Science

• Identifiers
  DOI 10.1152/ajpendo.00713.2009PMID 20332360PMCID PMC2886522
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Role of NADH/NAD+ transport activity and glycogen store on skeletal muscle energy metabolism during exercise: in silico studies.

  2009influential reference
• Exercise and diet enhance fat oxidation and reduce insulin resistance in older obese adults.

  2008cited by this paper
• Mitochondrial fitness and insulin sensitivity in humans

  2008cited by this paper
• Advances in male contraception.

  2008cited by this paper
• Cardiovascular actions of insulin.

  2007cited by this paper
• High-fat/low-carbohydrate diet reduces insulin-stimulated carbohydrate oxidation but stimulates nonoxidative glucose disposal in humans: An important role for skeletal muscle pyruvate dehydrogenase kinase 4.

  2007cited by this paper
• The underappreciated role of muscle in health and disease.

  2006cited by this paper
• Increased lipid availability impairs insulin-stimulated ATP synthesis in human skeletal muscle.

  2006cited by this paper
• The metabolic syndrome: role of skeletal muscle metabolism.

  2006cited by this paper
• Mechanistic model of fuel selection in the muscle.

  2006cited by this paper
• Effect of insulin on human skeletal muscle protein synthesis is modulated by insulin-induced changes in muscle blood flow and amino acid availability.

  2006cited by this paper
• Modeling the euglycemic hyperinsulinemic clamp by stochastic differential equations

  2006cited by this paper
• Malonyl-CoA and carnitine in regulation of fat oxidation in human skeletal muscle during exercise.

  2005cited by this paper
• Turning signals on and off: GLUT4 traffic in the insulin-signaling highway.

  2005cited by this paper
• Effect of insulin on human skeletal muscle mitochondrial ATP production, protein synthesis, and mRNA transcripts

  2003cited by this paper
• Blood flow and muscle metabolism: a focus on insulin action.

  2003cited by this paper
• Insulin resistance in type 2 diabetes: association with truncal obesity, impaired fitness, and atypical malonyl coenzyme A regulation.

  2003cited by this paper
• Insulin regulation of glucose uptake: a complex interplay of intracellular signalling pathways.

  2002cited by this paper
• Insulin regulation of glucose uptake: a complex interplay of intracellular signalling pathways

  2002cited by this paper
• A mathematical model of metabolic insulin signaling pathways.

  2002cited by this paper
• Modulation of Insulin Signaling in Human Skeletal Muscle in Response to Exercise

  2002cited by this paper
• Insulin signalling and the regulation of glucose and lipid metabolism

  2001cited by this paper
• New perspectives into the molecular pathogenesis and treatment of type 2 diabetes.

  2001cited by this paper
• Regulation of hexokinase II expression in human skeletal muscle in vivo.

  2000cited by this paper
• Fatty acid oxidation and the regulation of malonyl-CoA in human muscle.

  2000influential reference
• Regular exercise enhances insulin activation of IRS-1-associated PI3-kinase in human skeletal muscle.

  2000cited by this paper
• Malonyl-CoA, fuel sensing, and insulin resistance.

  1999cited by this paper
• Insulin regulation of glucose transport and phosphorylation in skeletal muscle assessed by PET.

  1999cited by this paper
• Insulin regulation of glucose transport and phosphorylation in skeletal muscle assessed by PET.

  1999cited by this paper
• Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss.

  1999influential reference
• Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss.

  1999cited by this paper
• Rapid impairment of skeletal muscle glucose transport/phosphorylation by free fatty acids in humans.

  1999cited by this paper
• Malonyl-CoA, fuel sensing, and insulin resistance.

  1999cited by this paper
• Insulin-induced hexokinase II expression is reduced in obesity and NIDDM.

  1998influential reference
• Interaction of carbohydrate and fat fuels in human skeletal muscle: impact of obesity and NIDDM.

  1996influential reference
• Roles of glucose transport and glucose phosphorylation in muscle insulin resistance of NIDDM.

  1996cited by this paper
• Human skeletal muscle malonyl-CoA at rest and during prolonged submaximal exercise.

  1996cited by this paper
• Regulation of hexokinase II and glycogen synthase mRNA, protein, and activity in human muscle.

  1995influential reference
• Non-esterified fatty acids regulate lipid and glucose oxidation and glycogen synthesis in healthy man

  1994cited by this paper
• Hexokinase kinetics in human skeletal muscle after hyperinsulinaemia, hyperglycaemia and hyperepinephrinaemia.

  1994cited by this paper
• Mechanisms of fatty acid-induced inhibition of glucose uptake.

  1994influential reference
• Glucose-fatty acid cycle operates in humans at the levels of both whole body and skeletal muscle during low and high physiological plasma insulin concentrations.

  1994cited by this paper
• Differential regulation of intracellular glucose metabolism by glucose and insulin in human muscle.

  1993influential reference
• Glycogen synthase and phosphofructokinase protein and mRNA levels in skeletal muscle from insulin-resistant patients with non-insulin-dependent diabetes mellitus.

  1993cited by this paper
• Phosphofructokinase activity in human skeletal muscle: effects of euglycaemic hyperinsulinaemia and fasting.

  1993cited by this paper
• Hyperglycemia induces accumulation of glucose in human skeletal muscle.

  1991cited by this paper
• Effects of insulin on skeletal muscle glucose storage, oxidation, and glycolysis in humans.

  1990cited by this paper
• Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy.

  1990cited by this paper
• No accumulation of glucose in human skeletal muscle during euglycemic hyperinsulinemia.

  1988cited by this paper
• Effects of insulin infusion on human skeletal muscle pyruvate dehydrogenase, phosphofructokinase, and glycogen synthase. Evidence for their role in oxidative and nonoxidative glucose metabolism.

  1987cited by this paper
• Glucose clamp technique: a method for quantifying insulin secretion and resistance.

  1979cited by this paper
• Theoretical Biology and Medical Modelling Open Access a Mathematical Model of the Euglycemic Hyperinsulinemic Clamp

  year unknowncited by this paper

• Modeling sex-specific whole-body metabolic responses to feeding and fasting

  2024cites this paper
• Virtual metabolic human dynamic model for pathological analysis and therapy design for diabetes

  2020cites this paper
• Mechanistic inferences on metabolic dysfunction in posttraumatic stress disorder from an integrated model and multiomic analysis: role of glucocorticoid receptor sensitivity

  2019cites this paper
• Modeling the Physiological Factors Affecting Glucose Sensor Function in Vivo

  2015cites this paper
• Simulation Predicts IGFBP2-HIF1α Interaction Drives Glioblastoma Growth

  2015cites this paper
• Mathematical modelling of hepatic lipid metabolism.

  2015cites this paper
• A Mathematical Model of the Human Metabolic System and Metabolic Flexibility

  2014influential citation
• Leucine facilitates the insulin-stimulated glucose uptake and insulin signaling in skeletal muscle cells: involving mTORC1 and mTORC2

  2014cites this paper
• The regulatory design of glycogen metabolism in mammalian skeletal muscle

  2013cites this paper
• Synergy in free radical generation is blunted by high-fat diet induced alterations in skeletal muscle mitochondrial metabolism.

  2013cites this paper
• Systems mapping of metabolic genes through control theory.

  2013cites this paper
• Dynamic Analysis of the Possible Effects of Leptin in Some Metabolic Disorders in Obesity

  2012cites this paper
• CALL FOR PAPERS Integrative and Translational Physiology: Integrative Aspects of Energy Homeostasis in Metabolic Disorders Model analysis of the relationship between intracellular P O 2 and energy demand in skeletal muscle

  2012cites this paper
• Computational Modeling of the Metabolic States Regulated by the Kinase Akt

  2012cites this paper
• Model analysis of the relationship between intracellular PO2 and energy demand in skeletal muscle.

  2012cites this paper
• Integrative and Translational Physiology : Integrative Aspects of Energy Homeostasis in Metabolic Disorders Model analysis of the relationship between intracellular PO 2 and energy demand in skeletal muscle

  2012cites this paper
• Stochastic Modeling of Blood Glucose Levels in Type-2 Diabetes Mellitus

  2011cites this paper
• Computational Model of Cellular Metabolic Dynamics in Skeletal Muscle Fibers During Moderate Intensity Exercise

  2011cites this paper
• COMPUTATIONAL MODELING OF IN VIVO METABOLIC PROCESSES IN SKELETAL MUSCLE

  2011cites this paper