Systems biology is taking off.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Genome Research

• Publication date

  2003-11-01

• Fields of study

  Biology, Mathematics, Computer Science, Medicine

• Identifiers
  DOI 10.1101/GR.1763203PMID 14597651
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The structure of deoxyribose nucleic acid.

  2004cited by this paper
• Fast evaluation of fluctuations in biochemical networks with the linear noise approximation.

  2003cited by this paper
• Cytoscape: a software environment for integrated models of biomolecular interaction networks.

  2003cited by this paper
• Genome-scale reconstruction of the Saccharomyces cerevisiae metabolic network.

  2003cited by this paper
• On schemes of combinatorial transcription logic

  2003cited by this paper
• Reverse engineering gene networks: Integrating genetic perturbations with dynamical modeling

  2003cited by this paper
• Importance of input perturbations and stochastic gene expression in the reverse engineering of genetic regulatory networks: insights from an identifiability analysis of an in silico network.

  2003cited by this paper
• Noise in eukaryotic gene expression

  2003cited by this paper
• Selective Charging of tRNA Isoacceptors Explains Patterns of Codon Usage

  2003cited by this paper
• Parameter estimation in biochemical pathways: a comparison of global optimization methods.

  2003cited by this paper
• Toward rigorous comprehension of biological complexity: modeling, execution, and visualization of thymic T-cell maturation.

  2003cited by this paper
• A biophysical approach to transcription factor binding site discovery.

  2003cited by this paper
• Stochastic Gene Expression in a Single Cell

  2002cited by this paper
• Genetic engineering using homologous recombination.

  2002cited by this paper
• Transcriptional Regulatory Networks in Saccharomyces cerevisiae

  2002cited by this paper
• Reverse Engineering of Biological Complexity

  2002cited by this paper
• Escherichia coli K-12 undergoes adaptive evolution to achieve in silico predicted optimal growth

  2002cited by this paper
• Regulation of noise in the expression of a single gene

  2002cited by this paper
• Specificity and Stability in Topology of Protein Networks

  2002cited by this paper
• Network motifs in the transcriptional regulation network of Escherichia coli

  2002cited by this paper
• Combinatorial Synthesis of Genetic Networks

  2002influential reference
• Robustness of the BMP morphogen gradient in Drosophila embryonic patterning

  2002cited by this paper
• A stochastic, molecular model of the fission yeast cell cycle: role of the nucleocytoplasmic ratio in cycle time regulation.

  2001cited by this paper
• In silico predictions of Escherichia coli metabolic capabilities are consistent with experimental data

  2001cited by this paper
• Regulatory element detection using correlation with expression

  2001cited by this paper
• Integrated genomic and proteomic analyses of a systematically perturbed metabolic network.

  2001cited by this paper
• Epigenetics as a first exit problem.

  2001cited by this paper
• Noise in a minimal regulatory network: plasmid copy number control

  2001cited by this paper
• Genes and Signals

  2001cited by this paper
• A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations

  2001cited by this paper
• A synthetic oscillatory network of transcriptional regulators

  2000cited by this paper
• Engineering stability in gene networks by autoregulation

  2000cited by this paper
• A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiae

  2000cited by this paper
• Global analysis of the genetic network controlling a bacterial cell cycle.

  2000cited by this paper
• Construction of a genetic toggle switch in Escherichia coli

  2000cited by this paper
• Quantitative analysis of complex protein mixtures using isotope-coded affinity tags

  1999cited by this paper
• Robustness in simple biochemical networks

  1997cited by this paper
• Stochastic Processes in Physics and Chemistry

  1995cited by this paper
• The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications.

  1987cited by this paper
• Costs of accuracy determined by a maximal growth rate constraint

  1984cited by this paper
• Attenuation in the control of expression of bacterial operons

  1981cited by this paper
• A model for the statistical fluctuations of protein numbers in a microbial population.

  1978cited by this paper
• General Nature of the Genetic Code for Proteins

  1961cited by this paper
• What is Life?

  1945cited by this paper
• Stochastic Gene Expression in a Single Cell

  year unknowncited by this paper
• Array of hope

  year unknowncited by this paper

• How acidic amino acid residues facilitate DNA target site selection

  2023cites this paper
• Systems biology of human aging: A Fibonacci time series model.

  2022cites this paper
• Pursuit of precision medicine: Systems biology approaches in Alzheimer’s disease mouse models

  2021cites this paper
• Chapter 2 Stochastic Modelling in Life Sciences

  2019cites this paper
• The influence of sequence context on the evolution of bacterial gene expression

  2018cites this paper
• Analyse métabolomique multidimensionnelle : applications aux erreurs innées du métabolisme

  2017cites this paper
• Advances in metabolome information retrieval: turning chemistry into biology. Part I: analytical chemistry of the metabolome

  2017cites this paper
• A stochastic nominal control optimizing the adoptive immunotherapy for cancer using tumor-infiltrating lymphocytes

  2017cites this paper
• A stochastic nominal control optimizing the adoptive immunotherapy for cancer using tumor-infiltrating lymphocytes

  2016cites this paper
• Clinical Metabolomics: The New Metabolic Window for Inborn Errors of Metabolism Investigations in the Post-Genomic Era

  2016cites this paper
• Modeling and Model Simplification to Facilitate Biological Insights and Predictions

  2016cites this paper
• Human cardiac systems electrophysiology and arrhythmogenesis: iteration of experiment and computation.

  2014cites this paper
• Decoding the complex genetic causes of heart diseases using systems biology

  2014cites this paper
• Stochastic Modelling in Life Sciences

  2013cites this paper
• El camino de la biotecnología en la Universidad Nacional Agraria La Molina, Perú

  2013cites this paper
• Complexity and the reductionism–holism debate in systems biology

  2012cites this paper
• On diverse biophysical aspects of genetics : from the action of regulators to the characterization of transcripts

  2011cites this paper
• PREPROCESSING AND BICLUSTERING OF HIGH-THROUGHPUT EXPRESSION DATA

  2010cites this paper
• Krylov and steady-state techniques for the solution of the chemical master equation for the mitogen-activated protein kinase cascade

  2009cites this paper
• A generic algorithm for layout of biological networks

  2009cites this paper
• Bayesian inference of biochemical kinetic parameters using the linear noise approximation

  2009cites this paper
• Multiscale Monte Carlo study of epidermal growth factor receptor diffusion and dimerization

  2009cites this paper
• Robustness Analysis of Intracellular Oscillators with Application to the Circadian Clock

  2008cites this paper
• Gene networks and modules in atherosclerosis

  2008cites this paper
• ANALYSIS OF KIDNEY GLOMERULAR AND MICROVASCULAR

  2007cites this paper
• Genome-wide dissection of cellular responses to DNA double-strand breaks using integrated analysis of expression microarrays and bioinformatics

  2007cites this paper
• Transcript and proteomic analyses of wild-type and gpa2 mutant Saccharomyces cerevisiae strains suggest a role for glycolytic carbon source sensing in pseudohyphal differentiation.

  2007cites this paper
• Analysis of kidney glomerular and microvascular transcriptomes

  2007cites this paper
• Dialysis at a crossroads: reverse engineering renal replacement therapy.

  2006cites this paper
• E. coli Genome

  2006cites this paper
• Inferring Transcriptional Networks by Mining 'Omics' Data

  2006cites this paper
• Multistability and Multicellularity: Cell Fates as High-dimensional Attractors of Gene Regulatory Networks

  2006cites this paper
• Spatial modeling of dimerization reaction dynamics in the plasma membrane: Monte Carlo vs. continuum differential equations.

  2006cites this paper
• The influence of the signal dynamics of activated form of IKK on NF‐κB and anti‐apoptotic gene expressions: A systems biology approach

  2006cites this paper
• Dimensional Reduction of the Fokker-Planck Equation for Stochastic Chemical Reactions

  2006cites this paper
• Conservative solution of the Fokker–Planck equation for stochastic chemical reactions

  2006cites this paper
• An optimal number of molecules for signal amplification and discrimination in a chemical cascade.

  2006cites this paper
• Genomic Feature Identification in Trypanosomatid Parasites

  2006cites this paper
• The Limits of Reductionism in Medicine: Could Systems Biology Offer an Alternative?

  2006cites this paper
• Chemical Proteomics in Drug Development

  2005cites this paper
• Fundamentals of surgical research course: functional genomics.

  2005cites this paper
• Numerical solution of the Fokker–Planck approximation of the chemical master equation

  2005cites this paper
• Mesoscopic kinetics and its applications in protein synthesis

  2005cites this paper
• Molecular dissection of B-lymphocyte signalling using expression profiling

  2005cites this paper
• Fundamental issues in systems biology.

  2005cites this paper
• Clinical Bioinformatics

  2005cites this paper
• Signal propagation in nonlinear stochastic gene regulatory networks.

  2005cites this paper
• Evaluation of the performance of mechanisms for noise attenuation in a single-gene expression.

  2005cites this paper
• Update on human genome completion and annotations: Protein information resource

  2004cites this paper
• Update on genome completion and annotations: Protein Information Resource

  2004cites this paper
• Microfluidic biosensing systems based on enzymes, antibodies and cells

  2004cites this paper
• In vivo non-specific binding of lambda CI and Cro repressors is significant.

  2004cites this paper
• Adaptive, Conservative Solution of the Fokker-Planck Equation in Molecular Biology

  2004cites this paper
• In vivo non‐specific binding of λ CI and Cro repressors is significant

  2004cites this paper
• From the sequence to cell modeling: comprehensive functional genomics in Escherichia coli.

  2004cites this paper
• Characterizing the reliability of a BioMEMS-based cantilever sensor

  2004cites this paper
• Building blocks of a biochemical CPU based on DNA transcription logic

  2004cites this paper
• Hypothesis driven modelling of long-distance signalling and plant development

  2004cites this paper