Stimulation of adenosine 3',5'-monophosphate formation by alpha and beta adrenergic agonists in rat cerebral cortical slices: effects of clonidine.

Clonidine has no significant effect on basal levels of cyclic 39,59-AMP in incubated slices of rat cerebral cortex, but this drug and oxymetazoline antagonize norepinerphrine-elicited accumulation of cyclic AMP to a degree which corresponds to the alpha adrenergic component of the norepinephrine response. Phenylephrine has virtually no agonist or antagonist activity in the brain slice system. Clonidine does not antagonize the accumulation of cyclic AMP elicited by maximal concentrations of a beta adrenergic agonist, isoproterenol, and markedly potentiates the stimulatory effects of submaximal concentrations of this agonist. Clonidine completely antagonizes the formation of cyclic AMP elicited by methoxamine, an alpha adrenergic agonist. The results indicate that clonidine and oxymetazoline function as potent antagonists with respect to norepinephrine- and methoxamine-stimulated formation of cyclic AMP in brain tissue, presumably at an alpha adrenergic locus. In addition, clonidine, oxymetazoline, and phenylephrine appear to interact synergistically with the beta adrenergic component of cyclic AMP-generating systems, thus functioning as partial agonists in brain slices under certain conditions.

• Publication year

  1975

• Venue

  Molecular Pharmacology

• Publication date

  1975-09-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/s0026-895x(25)10669-xPMID 241008
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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