Mucosal interplay among commensal and pathogenic bacteria: Lessons from flagellin and Toll‐like receptor 5

Toll‐like receptors (TLR) detect pathogen‐associated molecular patterns (PAMP) and play a crucial role in triggering immunity. Due to their large surfaces in direct contact with the environment, mucosal tissues are the major sites of PAMP‐TLR signalling. How innate and adaptive immunity are triggered through flagellin–TLR5 interaction is the main focus of the review. In view of recent reports on genetic polymorphism, we will summarize the impact of TLR5 on the susceptibility to mucosal infections and on various immuno‐pathologies. Finally, the contribution of TLRs in the induction and maintenance of mucosal homeostasis and commensal discrimination is discussed.

• Publication year

  2006

• Venue

  FEBS Letters

• Publication date

  2006-05-22

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.febslet.2006.04.036PMID 16650409
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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