Sublingual Delivery of Vaccines for the Induction of Mucosal Immunity

The mucosal surfaces are constantly exposed to incoming pathogens which can cause infections that result in severe morbidity and/or mortality. Studies have reported that mucosal immunity is important for providing protection against these pathogens and that mucosal vaccination is effective in preventing local infections. For many years, the sublingual mucosa has been targeted to deliver immunotherapy to treat allergic hypersensitivities. However, the potential of vaccine delivery via sublingual mucosal has received little attention until recently. Recent studies exploring such potential have documented the safety and effectiveness of sublingual immunization, demonstrating the ability of sublingual immunization to induce both systemic and mucosal immune responses against a variety of antigens, including soluble proteins, inter particulate antigens, and live-attenuated viruses. This review will summarize the recent findings that address the promising potential of sublingual immunization in proving protection against various mucosal pathogens.

• Publication year

  2013

• Venue

  Immune Network

• Publication date

  2013-06-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.4110/in.2013.13.3.81PMID 23885221PMCID 3718922
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• MUCOSAL IMMUNITY AND VACCINES

  2013cited by this paper
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  2012cited by this paper
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  2012influential reference
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  2012influential reference
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  2012cited by this paper
• Sublingual Immunization with a Live Attenuated Influenza A Virus Lacking the Nonstructural Protein 1 Induces Broad Protective Immunity in Mice

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• Sublingual Immunization with M2-Based Vaccine Induces Broad Protective Immunity against Influenza

  2011influential reference
• Allergen-specific immunotherapy for respiratory allergies: from meta-analysis to registration and beyond.

  2011influential reference
• Sublingual immunization with an HIV subunit vaccine induces antibodies and cytotoxic T cells in the mouse female genital tract.

  2010influential reference
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  2009influential reference
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• Sublingual vaccination with influenza virus protects mice against lethal viral infection

  2008influential reference
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  2007cited by this paper
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  2007cited by this paper
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  2006cited by this paper
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  2006cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2015cites this paper
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