The antioxidant edaravone attenuates ER-stress-mediated cardiac apoptosis and dysfunction in rats with autoimmune myocarditis

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Free radical research

• Publication date

  2010-09-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.3109/10715762.2010.499904PMID 20815771
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• ER stress in cardiovascular disease.

  2010cited by this paper
• In situ localization of apoptosis using TUNEL.

  2010cited by this paper
• Approach of empirical antibiotic treatment: analyzing bacterial resistance of community-acquired bacteremia.

  2010cited by this paper
• Protective effects of the free radical scavenger edaravone on acute pancreatitis-associated lung injury.

  2010cited by this paper
• MCP-1 causes cardiomyoblast death via autophagy resulting from ER stress caused by oxidative stress generated by inducing a novel zinc-finger protein, MCPIP.

  2010cited by this paper
• Immunoregulatory Effects of Carvedilol on Rat Experimental Autoimmune Myocarditis

  2009cited by this paper
• Attenuation of experimental autoimmune myocarditis by blocking T cell activation through 4-1BB pathway.

  2009cited by this paper
• Endoplasmic reticulum proteins in cardiac development and dysfunction.

  2009cited by this paper
• Oxidative stress and redox regulation -protein oxidative modification and activation-

  2009cited by this paper
• Mechanisms and Implications of Reactive Oxygen Species Generation During the Unfolded Protein Response: Roles of Endoplasmic Reticulum Oxidoreductases, Mitochondrial Electron Transport, and NADPH Oxidase

  2009cited by this paper
• [Effects of various diuretics on cardiac function in rats with heart failure].

  2009cited by this paper
• Oxidative stress and mitochondrial DNA damage in heart failure.

  2008cited by this paper
• The radical scavenger edaravone counteracts diabetes in multiple low-dose streptozotocin-treated mice.

  2008cited by this paper
• NADPH oxidase-derived reactive oxygen species in the regulation of endothelial phenotype.

  2008cited by this paper
• Oxidative Stress and Mitochondrial DNA Damage in Heart Failure(Molecular Mechanisms)

  2008cited by this paper
• Edaravone, a potent free radical scavenger, prevents anthracycline-induced myocardial cell death.

  2007cited by this paper
• Endoplasmic reticulum stress: signaling the unfolded protein response.

  2007cited by this paper
• Endoplasmic Reticulum Stress

  2007cited by this paper
• The Rac Effector p67phox Regulates Phagocyte NADPH Oxidase by Stimulating Vav1 Guanine Nucleotide Exchange Activity

  2006cited by this paper
• Edaravone inhibits JNK-c-Jun pathway and restores anti-oxidative defense after ischemia-reperfusion injury in aged rats.

  2006influential reference
• Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a novel free radical scavenger, for treatment of cardiovascular diseases.

  2006cited by this paper
• MCI-186 (edaravone), a novel free radical scavenger, protects against acute autoimmune myocarditis in rats.

  2005cited by this paper
• [Role of endoplasmic reticulum stress in hypertrophic and failing hearts].

  2005cited by this paper
• The Antioxidant Edaravone Attenuates Pressure Overload–Induced Left Ventricular Hypertrophy

  2005cited by this paper
• Anti-apoptotic and neuroprotective effects of edaravone following transient focal ischemia in rats.

  2005cited by this paper
• Giant Cell Myocarditis

  2005cited by this paper
• Cardioprotective effects of 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186), a novel free radical scavenger, on acute autoimmune myocarditis in rats.

  2004cited by this paper
• Roles of CHOP/GADD153 in endoplasmic reticulum stress

  2004cited by this paper
• Edaravone Protects against Hypoxia/Ischemia-Induced Endoplasmic Reticulum Dysfunction

  2004cited by this paper
• Atheroprotective effects of antioxidants through inhibition of mitogen-activated protein kinases.

  2004cited by this paper
• Effects of edaravone on reperfusion injury in patients with acute myocardial infarction.

  2004influential reference
• [Research and development of the free radical scavenger edaravone as a neuroprotectant].

  2004cited by this paper
• Cardioprotective effects of carvedilol on acute autoimmune myocarditis

  2004cited by this paper
• Research and development of the free radical scavenger edaravone as a neuroprotectant

  2004cited by this paper
• Effects of edaravone on experimental brain injury in view of free radical reaction.

  2003cited by this paper
• Cardioprotective effects of carvedilol on acute autoimmune myocarditis.

  2003cited by this paper
• Immune-mediated myocarditis and interleukin-10

  2003cited by this paper
• Stress in cardiovascular diseases.

  2002cited by this paper
• Redox Control of Cell Death

  2002cited by this paper
• Low dose carvedilol inhibits progression of heart failure in rats with dilated cardiomyopathy

  2000cited by this paper
• Oxidative stress and apoptosis.

  2000cited by this paper
• Role of oxidative stress in cardiovascular diseases

  2000cited by this paper
• Myocarditis.

  2000cited by this paper
• [Oxidative stress and apoptosis].

  1996cited by this paper
• Effects of an antistroke agent MCl-186 on cerebral arachidonate cascade.

  1994cited by this paper
• Protective effects of MCI-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions.

  1994cited by this paper
• Rat dilated cardiomyopathy after autoimmune giant cell myocarditis.

  1994cited by this paper
• Lipid peroxidation: its mechanism, measurement, and significance.

  1993cited by this paper
• Characteristics of giant cells and factors related to the formation of giant cells in myocarditis.

  1991cited by this paper
• Effect of MCI-186 on ischemia-induced changes in monoamine metabolism in rat brain.

  1989cited by this paper
• Effect of MCI-186 on brain edema in rats.

  1989cited by this paper
• Risk factors for the development of prosthetic valve endocarditis.

  1985cited by this paper

• Multifunctional nanoparticles for immune regulation and oxidative stress alleviation in myocarditis.

  2025cites this paper
• Modulation of TLR4/NFκB Pathways in Autoimmune Myocarditis

  2023cites this paper
• Effects and mechanisms of animal-free hydrolysates on recombination protein yields in CHO cells

  2022cites this paper
• Therapeutic Effects of Edaravone on Azoospermia: Free Radical Scavenging and Autophagy Modulation in Testicular Tissue of Mice

  2022cites this paper
• The Classification and Prediction of Ferroptosis-Related Genes in ALS: A Pilot Study

  2022cites this paper
• Edaravone Ameliorates Renal Warm Ischemia-Reperfusion Injury by Downregulating Endoplasmic Reticulum Stress in a Rat Resuscitation Model

  2020cites this paper
• Edaravone Ameliorates Renal Warm Ischemia-Reperfusion Injury by Downregulating Endoplasmic Reticulum Stress in a Rat Resuscitation Model

  2020cites this paper
• Chitoheptaose Promotes Heart Rehabilitation in a Rat Myocarditis Model by Improving Antioxidant, Anti-Inflammatory, and Antiapoptotic Properties

  2020cites this paper
• Cardiac apoptosis caused by elevated cholesterol level in experimental autoimmune myocarditis.

  2020cites this paper
• STAT4 silencing underlies a novel inhibitory role of microRNA-141-3p in inflammation response of mice with experimental autoimmune myocarditis.

  2019cites this paper
• Regulation of mitochondrial function by Myocardin during cardiac development and disease

  2019cites this paper
• Novel approaches in the treatment of diabetic cardiomyopathy.

  2018cites this paper
• Abstracts from the 25th European Society for Animal Cell Technology Meeting: Cell Technologies for Innovative Therapies

  2018cites this paper
• РЕТИКУЛУМА (СООБЩЕНИЕ NEPHROLOGIST’S IMPRESSION OF ENDOPLASMATIC RETICULUM STRESS

  2018cites this paper
• Baicalein Reduces Oxidative Stress in CHO Cell Cultures and Improves Recombinant Antibody Productivity.

  2018cites this paper
• 3,5-Dimethoxy-4-hydroxy myricanol ameliorates photoreceptor cell degeneration in Pde6brd 10 mouse model

  2018cites this paper
• Effective Agents Targeting the Mitochondria and Apoptosis to Protect the Heart.

  2017cites this paper
• Effect of PKC inhibitor on experimental autoimmune myocarditis in Lewis rats

  2017cites this paper
• The senescence accelerated mouse prone 8 (SAMP8): A novel murine model for cardiac aging.

  2017cites this paper
• Progressing neurobiological strategies against proteostasis failure: Challenges in neurodegeneration.

  2017cites this paper
• Oxidative stress and myocarditis.

  2016cites this paper
• Effects of 1, 25-Dihydroxyvitamin D3 on Experimental Autoimmune Myocarditis in Mice

  2016cites this paper
• Carnosic acid slows photoreceptor degeneration in the Pde6brd10 mouse model of retinitis pigmentosa

  2016cites this paper
• Role of MAPK-mediated endoplasmic reticulum stress signaling in the heart during aging in senescence-accelerated prone mice.

  2016cites this paper
• Recent advances in the management of autoimmune myocarditis: insights from animal studies.

  2016cites this paper
• Cytoprotective role of the fatty acid binding protein 4 against oxidative and endoplasmic reticulum stress in 3T3-L1 adipocytes

  2014cites this paper
• Experimental drugs for treatment of autoimmune myocarditis.

  2014cites this paper
• Mulberry leaf diet protects against progression of experimental autoimmune myocarditis to dilated cardiomyopathy via modulation of oxidative stress and MAPK-mediated apoptosis.

  2013cites this paper
• Redox-Sensitive Endoplasmic Reticulum Stress and Autophagy at Rostral Ventrolateral Medulla Contribute to Hypertension in Spontaneously Hypertensive Rats

  2013cites this paper
• Xenobiotic Perturbation of ER Stress and the Unfolded Protein Response

  2013cites this paper
• The Efficacy of Edaravone (Radicut), a Free Radical Scavenger, for Cardiovascular Disease

  2013influential citation
• InterfERing with endoplasmic reticulum stress.

  2012cites this paper
• Beyond free radical scavenging: Beneficial effects of edaravone (Radicut) in various diseases (Review).

  2012influential citation
• NADPH oxidase-dependent oxidative stress in the failing heart: From pathogenic roles to therapeutic approach.

  2012cites this paper
• Beneficial effects of edaravone, a novel antioxidant, in rats with dilated cardiomyopathy

  2012cites this paper
• Involvement of AMPK and MAPK signaling during the progression of experimental autoimmune myocarditis in rats and its blockade using a novel antioxidant.

  2012cites this paper
• Quercetin offers cardioprotection against progression of experimental autoimmune myocarditis by suppression of oxidative and endoplasmic reticulum stress via endothelin-1/MAPK signalling

  2012cites this paper
• Proteomic and biochemical analyses reveal the activation of unfolded protein response, ERK-1/2 and ribosomal protein S6 signaling in experimental autoimmune myocarditis rat model

  2011cites this paper
• Beyond neurological disease: new targets for edaravone (Review).

  2011cites this paper
• Cell death signalling mechanisms in heart failure.

  2011cites this paper
• Edaravone, an ROS scavenger, ameliorates photoreceptor cell death after experimental retinal detachment.

  2011cites this paper
• Olmesartan, an AT1 Antagonist, Attenuates Oxidative Stress, Endoplasmic Reticulum Stress and Cardiac Inflammatory Mediators in Rats with Heart Failure Induced by Experimental Autoimmune Myocarditis

  2011cites this paper
• Endoplasmic reticulum proteins in cardiac development and dysfunction.

  2009cites this paper