Is there still a place for vasopressors in the treatment of cardiac arrest?

Around 300,000 people in the United States experience an out-of-hospital cardiac arrest each year, and less than 10 % of them survive to hospital discharge [1]. Survival is only slightly better for in-hospital cardiac arrest [2]. While provision of basic measures like bystander cardiopulmonary resuscitation (CPR) or early defibrillation is consistently associated with better survival [3], the benefit of advanced life support (ALS) measures, such as ventilation with advanced airway and administration of drugs, has not been clearly demonstrated [4].

• Publication year

  2012

• Venue

  Critical Care

• Publication date

  2012-03-20

• Fields of study

  Medicine

• Identifiers
  DOI 10.1186/cc11227PMID 22429716PMCID 3681358
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Vasopressin for cardiac arrest: meta-analysis of randomized controlled trials.

  2012cited by this paper
• Effect of adrenaline on survival in out-of-hospital cardiac arrest: A randomised double-blind placebo-controlled trial.

  2011cited by this paper
• Contemporary Reviews in Cardiovascular Medicine Post Cardiac Arrest Syndrome A Review of Therapeutic Strategies

  2011cited by this paper
• Out-of-hospital cardiac arrest surveillance --- Cardiac Arrest Registry to Enhance Survival (CARES), United States, October 1, 2005--December 31, 2010.

  2011cited by this paper
• Intravenous Drug Administration During Out-Of-Hospital Cardiac Arrest: A Randomized Trial

  2010cited by this paper
• Predictors of Survival From Out-of-Hospital Cardiac Arrest: A Systematic Review and Meta-Analysis

  2010cited by this paper
• European Resuscitation Council Guidelines for Resuscitation 2010 Section 4. Adult advanced life support.

  2010cited by this paper
• Cardiac arrest centres make sense.

  2010cited by this paper
• Part 8: adult advanced cardiovascular life support: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care.

  2010cited by this paper
• Therapeutic hypothermia after cardiac arrest – implementation in UK intensive care units *

  2010cited by this paper
• Intra-Arrest Transnasal Evaporative Cooling: A Randomized, Prehospital, Multicenter Study (PRINCE Pre-ROSC IntraNasal Cooling Effectiveness)

  2010cited by this paper
• Intravenous drug administration during out-of-hospital cardiac arrest: a randomized trial.

  2009influential reference
• Epinephrine reduces cerebral perfusion during cardiopulmonary resuscitation*

  2009cited by this paper
• Vasopressin, epinephrine, and corticosteroids for in-hospital cardiac arrest.

  2009cited by this paper
• Vasopressin and epinephrine vs. epinephrine alone in cardiopulmonary resuscitation.

  2008cited by this paper
• Left Ventricular Systolic Function and Outcome After In-Hospital Cardiac Arrest

  2008influential reference
• In-hospital cardiac arrest: incidence, prognosis and possible measures to improve survival

  2007cited by this paper
• Therapeutic hypothermia utilization among physicians after resuscitation from cardiac arrest*

  2006cited by this paper
• Epinephrine and vasopressin during cardiopulmonary resuscitation.

  2005cited by this paper
• A Comparison of Vasopressin and Epinephrine for Out-of-Hospital Cardiopulmonary Resuscitation

  2004cited by this paper
• Advanced cardiac life support in out-of-hospital cardiac arrest.

  2004cited by this paper
• Mode of death after admission to an intensive care unit following cardiac arrest

  2004cited by this paper
• A comparison of vasopressin and epinephrine for out-of-hospital cardiopulmonary resuscitation.

  2004cited by this paper
• Regional anaesthesia

  2003cited by this paper
• Treatment of Comatose Survivors of Out-of-hospital Cardiac Arrest With Induced Hypothermia

  2003cited by this paper
• A survey of the in-hospital response to cardiac arrest on general wards in the hospitals of Rome.

  2003cited by this paper
• Reversible myocardial dysfunction in survivors of out-of-hospital cardiac arrest.

  2002cited by this paper
• Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest.

  2002cited by this paper
• The Effects of Endogenous and Exogenous Vasopressin During Experimental Cardiopulmonary Resuscitation

  2002cited by this paper
• Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia.

  2002cited by this paper
• Vasopressin versus epinephrine for inhospital cardiac arrest: a randomised controlled trial.

  2001cited by this paper
• Vasopressin and epinephrine for cardiac arrest.

  2001cited by this paper
• The Effects of Endogenous and Exogenous Vasopressin During Experimental Cardiopulmonary Resuscitation

  2001cited by this paper
• Vasopressin improves vital organ blood flow after prolonged cardiac arrest with postcountershock pulseless electrical activity in pigs.

  1999cited by this paper
• Repeated administration of vasopressin but not epinephrine maintains coronary perfusion pressure after early and late administration during prolonged cardiopulmonary resuscitation in pigs.

  1999cited by this paper
• European Resuscitation Council Guidelines for Resuscitation

  1998influential reference
• Randomised comparison of epinephrine and vasopressin in patients with out-of-hospital ventricular fibrillation.

  1997cited by this paper
• Cardiovascular function during the postresuscitation phase after cardiac arrest in pigs: a comparison of epinephrine versus vasopressin.

  1996cited by this paper
• Vasopressin improves vital organ blood flow during closed-chest cardiopulmonary resuscitation in pigs.

  1995cited by this paper
• Contractile dysfunction and abnormal Ca2+ modulation during postischemic reperfusion in rat heart.

  1995cited by this paper
• Epinephrine increases the severity of postresuscitation myocardial dysfunction.

  1995cited by this paper
• Vasopressin Improves Vital Organ Blood Flow During Closed-Chest Cardiopulmonary Resuscitation in Pigs

  1995cited by this paper
• Adult advanced life support

  1994cited by this paper
• Stress hormone response during and after cardiopulmonary resuscitation.

  1992cited by this paper
• Coronary perfusion pressure and the return of spontaneous circulation in human cardiopulmonary resuscitation.

  1990cited by this paper
• Simultaneous infusion of nitroglycerin and nitroprusside to offset adverse effects of vasopressin during portosystemic shunting.

  1989cited by this paper
• Human alveolar macrophage arachidonic acid metabolism.

  1988cited by this paper
• Direct G protein gating of ion channels.

  1988cited by this paper
• Myocardial perfusion pressure: a predictor of 24-hour survival during prolonged cardiac arrest in dogs.

  1988cited by this paper
• Failure of epinephrine to improve the balance between myocardial oxygen supply and demand during closed-chest resuscitation in dogs.

  1988influential reference
• The effect of epinephrine versus methoxamine on regional myocardial blood flow and defibrillation rates following a prolonged cardiorespiratory arrest in a swine model.

  1987cited by this paper
• What role do alpha- and beta-adrenoceptors play in the regulation of the heart?

  1983cited by this paper
• What role do α- and β-adrenoceptors play in the regulation of the heart?

  1983cited by this paper

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  2020cites this paper
• Intraosseous access over central venous or peripheral venous line as an initial means of resuscitation- A possible measure for improving outcomes of cardiac arrests.

  2017cites this paper
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  2015cites this paper