Signaling in Migrating Neurons: From Molecules to Networks

During prenatal and postnatal development of the mammalian brain, new neurons are generated by precursor cells that are located in the germinal zones. Subsequently newborn neurons migrate to their destined location in the brain. On the migrational route immature neurons interact via a series of recognition molecules with a plethora of extracellular cues. Stimuli that are conveyed by extracellular cues are translated into complex intracellular signaling networks that eventually enable neuronal migration. In this Focused Review we discuss signaling networks underlying neuronal migration emphasizing molecules and pathways that appear to be neuron-specific.

• Publication year

  2011

• Venue

  Frontiers in Neuroscience

• Publication date

  2011-01-19

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3389/fnins.2011.00028PMID 21629825PMCID 3096852
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Trio Is a Key Guanine Nucleotide Exchange Factor Coordinating Regulation of the Migration and Morphogenesis of Granule Cells in the Developing Cerebellum*

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  2010cited by this paper
• Biochemical and Functional Interaction of Disrupted-in-Schizophrenia 1 and Amyloid Precursor Protein Regulates Neuronal Migration during Mammalian Cortical Development

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• Increased subventricular zone-derived cortical neurogenesis after ischemic lesion.

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• Signaling involved in neurite outgrowth of postnatally born subventricular zone neurons in vitro

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  2009influential reference
• Major Signaling Pathways in Migrating Neuroblasts

  2009influential reference
• Mechanisms and functional implications of adult neurogenesis.

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  2007cited by this paper
• Neuronal migration in the adult brain: are we there yet?

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• Semaphorin regulation of cellular morphology.

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• Trekking across the brain: the journey of neuronal migration.

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• Divergent roles of ApoER2 and Vldlr in the migration of cortical neurons

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• Long-range Ca2+ signaling from growth cone to soma mediates reversal of neuronal migration induced by slit-2.

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• N-syndecan deficiency impairs neural migration in brain

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• Integrating new neurons into the adult olfactory bulb: joining the network, life-death decisions, and the effects of sensory experience.

  2005cited by this paper
• Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor.

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• FARP2 triggers signals for Sema3A-mediated axonal repulsion

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• The yeast kinome displays scale free topology with functional hub clusters

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• Growth and survival signals controlling sympathetic nervous system development.

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• Adhesion molecule L1 stimulates neuronal migration through Vav2-Pak1 signaling

  2004cited by this paper
• The molecular mystery of neuronal migration: FAK and Cdk5.

  2004cited by this paper
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  2004cited by this paper
• Functional significance of adult neurogenesis.

  2004cited by this paper
• Cortical neuronal migration mutants suggest separate but intersecting pathways.

  2004cited by this paper
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  2003cited by this paper
• Selective regulation of neurite extension and synapse formation by the beta but not the alpha isoform of CaMKII.

  2003cited by this paper
• Cell migration in the forebrain.

  2003cited by this paper
• Cyclin-Dependent Kinase 5 and Neuronal Migration in the Neocortex

  2003cited by this paper
• Phosphatidylinositol 3-Kinase Interacts with the Adaptor Protein Dab1 in Response to Reelin Signaling and Is Required for Normal Cortical Lamination*

  2003cited by this paper
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  2003cited by this paper
• Selective Regulation of Neurite Extension and Synapse Formation by the β but not the α Isoform of CaMKII

  2003cited by this paper
• Roles of Rho-family GTPases in cell polarisation and directional migration.

  2003cited by this paper
• Interaction of reelin signaling and Lis1 in brain development

  2003cited by this paper
• Pctaire1 Interacts with p35 and Is a Novel Substrate for Cdk5/p35*

  2002cited by this paper
• Cyclin-Dependent Kinase 5 Phosphorylates Disabled 1 Independently of Reelin Signaling

  2002cited by this paper
• Rat forebrain neurogenesis and striatal neuron replacement after focal stroke

  2002cited by this paper
• Activation of the repulsive receptor Roundabout inhibits N-cadherin-mediated cell adhesion

  2002cited by this paper
• Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway.

  2001cited by this paper
• Telencephalic cells take a tangent: non-radial migration in the mammalian forebrain

  2001cited by this paper
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  2000cited by this paper
• Reelin binds alpha3beta1 integrin and inhibits neuronal migration.

  2000cited by this paper
• Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth.

  2000cited by this paper
• Cellular and molecular determinants of sympathetic neuron development.

  1999cited by this paper
• Mouse disabled (mDab1): a Src binding protein implicated in neuronal development

  1997cited by this paper

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  2018cites this paper
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  2013cites this paper
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