Hemorrhagic shock primes the hepatic portal circulation for the vasoconstrictive effects of endothelin-1.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  American Journal of Physiology. Heart and Circulatory Physiology

• Publication date

  2001-09-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1152/AJPHEART.2001.281.3.H1075PMID 11514273
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1990cited by this paper
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  1990cited by this paper
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  1980influential reference
• Multiple organ failure.

  1977cited by this paper
• Hepatic outflow resistance, sinusoid pressure, and the vascular waterfall.

  1974cited by this paper

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