The Effect of O 6-Alkylguanine-DNA Alkyltransferase and Mismatch Repair Activities on the Sensitivity of Human Melanoma Cells to Temozolomide, 1,3-bis(2-Chloroethyl)1-nitrosourea, and Cisplatin

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Journal of Pharmacology and Experimental Therapeutics

• Publication date

  2003-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1124/jpet.102.043950PMID 12538819
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• High-frequency microsatellite instability is associated with defective DNA mismatch repair in human melanoma.

  2002influential reference
• Clinical relevance of MGMT in the treatment of cancer.

  2002cited by this paper
• Drug resistance towards etoposide and cisplatin in human melanoma cells is associated with drug-dependent apoptosis deficiency.

  2002cited by this paper
• Drug‐resistance in human melanoma

  2001cited by this paper
• Single-agent DTIC versus combination chemotherapy with or without immunotherapy in metastatic melanoma: a meta-analysis of 3273 patients from 20 randomized trials

  2001cited by this paper
• Tolerance of human MSH2+/− lymphoblastoid cells to the methylating agent temozolomide

  2001cited by this paper
• Mechanisms of tolerance to DNA damaging therapeutic drugs.

  2001cited by this paper
• Molecular mechanisms involved in cisplatin cytotoxicity

  2000cited by this paper
• Human melanoma cells secrete and respond to placenta growth factor and vascular endothelial growth factor.

  2000influential reference
• O6-alkylguanine-DNA alkyltransferase assay.

  2000cited by this paper
• Mismatch repair defects in cancer.

  2000cited by this paper
• Randomized phase III study of temozolomide versus dacarbazine in the treatment of patients with advanced metastatic malignant melanoma.

  2000cited by this paper
• The chemoresistance of human malignant melanoma: an update.

  1999cited by this paper
• O (6)-Alkylguanine-DNA Alkyltransferase Assay.

  1999cited by this paper
• Resistance to cisplatin.

  1999cited by this paper
• N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea sensitivity in mismatch repair-defective human cells.

  1998cited by this paper
• Involvement of the mismatch repair system in temozolomide-induced apoptosis.

  1998cited by this paper
• Mismatch G-T binding activity and MSH2 expression is quantitatively related to sensitivity of cells to methylating agents.

  1998cited by this paper
• Mammalian 3-methyladenine DNA glycosylase protects against the toxicity and clastogenicity of certain chemotherapeutic DNA cross-linking agents.

  1998cited by this paper
• The role of DNA mismatch repair in drug resistance.

  1998cited by this paper
• P III A.8 Sensitivity to CCNU in methylation tolerant mismatch repair defective human cells

  1997cited by this paper
• Effect of single and multiple administration of an O 6-benzylguanine/temozolomide combination: an evaluation in a human melanoma xenograft model

  1997cited by this paper
• Strand-specific Mismatch Repair in Mammalian Cells*

  1997cited by this paper
• O6-benzylguanine and its role in chemotherapy.

  1997cited by this paper
• Inhibition of O6-alkylguanine DNA-alkyltransferase or poly(ADP-ribose) polymerase increases susceptibility of leukemic cells to apoptosis induced by temozolomide.

  1997cited by this paper
• 3-aminobenzamide and/or O6-benzylguanine evaluated as an adjuvant to temozolomide or BCNU treatment in cell lines of variable mismatch repair status and O6-alkylguanine-DNA alkyltransferase activity.

  1996cited by this paper
• Potentiation of temozolomide and BCNU cytotoxicity by O(6)-benzylguanine: a comparative study in vitro.

  1996cited by this paper
• Triazene compounds induce apoptosis in O6-alkylguanine-DNA alkyltransferase deficient leukemia cell lines.

  1995cited by this paper
• Structure, function, and inhibition of O6-alkylguanine-DNA alkyltransferase.

  1995influential reference
• O6-methylguanine-DNA methyltransferase activities in biopsies of human melanoma tumours.

  1995cited by this paper
• Chemosensitivity testing of human malignant melanoma. A retrospective analysis of clinical response and in vitro drug sensitivity

  1994cited by this paper
• O6-alkylguanine DNA-alkyltransferase is not a major determinant of sensitivity to 1,3-bis(2-chloroethyl)-1-nitrosourea in four medulloblastoma cell lines.

  1992cited by this paper
• Immunohistological examination of the inter- and intracellular distribution of O6-alkylguanine DNA-alkyltransferase in human liver and melanoma.

  1992cited by this paper
• Heteroduplex repair in extracts of human HeLa cells.

  1991cited by this paper
• Effect of O6-benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents.

  1991cited by this paper
• Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents.

  1990cited by this paper
• Quenching of DNA cross-link precursors of chloroethylnitrosoureas and attenuation of DNA interstrand cross-linking by glutathione.

  1989cited by this paper
• Denitrosation of 1,3-bis(2-chloroethyl)-1-nitrosourea by class mu glutathione transferases and its role in cellular resistance in rat brain tumor cells.

  1989cited by this paper
• Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill.

  1989cited by this paper
• Formation of the cross-link 1-[N3-deoxycytidyl),2-[N1-deoxyguanosinyl]ethane in DNA treated with N,N'-bis(2-chloroethyl)-N-nitrosourea.

  1982cited by this paper
• Comparison of histocompatibility antigens on cultured human tumor cells and fibroblasts by quantitative antibody absorption and sensitivity to cell-mediated cytotoxicity.

  1976cited by this paper

• DNA damage caused by chemotherapy has duality, and traditional Chinese medicine may be a better choice to reduce its toxicity

  2024cites this paper
• Novel Imidazotetrazine Evades Known Resistance Mechanisms and Is Effective against Temozolomide-Resistant Brain Cancer in Cell Culture.

  2022cites this paper
• The Role of Mismatch Repair in Glioblastoma Multiforme Treatment Response and Resistance.

  2021cites this paper
• Molecular Mechanisms of Drug Resistance in Glioblastoma

  2021cites this paper
• Durable Near-Complete Response to Olaparib Plus Temozolomide and Radiation in a Patient With ATM-Mutated Glioblastoma and MSH6-Deficient Lynch Syndrome

  2020cites this paper
• Chloroethylating anticancer drug-induced mutagenesis and its repair in Escherichia coli

  2019cites this paper
• Synthesis of Oligonucleotides Carrying Nucleic Acid Derivatives of Biomedical and Structural Interest

  2018cites this paper
• Acquired temozolomide resistance in human glioblastoma cell line U251 is caused by mismatch repair deficiency and can be overcome by lomustine

  2018cites this paper
• Determining how chromatin structure is restored after repair of UV damage in Saccharomyces cerevisiae

  2018cites this paper
• Programmable and Multifunctional DNA‐Based Materials for Biomedical Applications

  2018cites this paper
• Function of high-mobility group A proteins in the DNA damage signaling for the induction of apoptosis

  2016cites this paper
• Targeting the PI3K/AKT/mTOR pathway overcomes the stimulating effect of dabrafenib on the invasive behavior of melanoma cells with acquired resistance to the BRAF inhibitor.

  2016cites this paper
• The role of temozolomide in the treatment of aggressive pituitary tumors.

  2015cites this paper
• The DNA damage response: implications for tumor responses to radiation and chemotherapy.

  2015influential citation
• Influence of fatty acid synthase inhibitor orlistat on the DNA repair enzyme O6-methylguanine-DNA methyltransferase in human normal or malignant cells in vitro.

  2015cites this paper
• Synthesis of oligonucleotides carrying fluorescently labelled O(6)-alkylguanine for measuring hAGT activity.

  2015cites this paper
• Repair mechanisms help glioblastoma resist treatment.

  2015cites this paper
• Response of primary glioblastoma cells to therapy is patient specific and independent of cancer stem cell phenotype.

  2014cites this paper
• Treatment for Glioblastoma Reversing the Warburg Effect as a Metabolism

  2014cites this paper
• Molecular status of pituitary carcinoma and atypical adenoma that contributes the effectiveness of temozolomide

  2014cites this paper
• DNA damage-induced cell death: from specific DNA lesions to the DNA damage response and apoptosis.

  2013cites this paper
• A Phase II Study of Temozolomide in Patients with Advanced Aerodigestive Tract and Colorectal Cancers and Methylation of the O6-Methylguanine-DNA Methyltransferase Promoter

  2013influential citation
• The antiretroviral agent saquinavir enhances hTERT expression and telomerase activity in human T leukaemia cells in vitro

  2013cites this paper
• Triazene compounds in the treatment of acute myeloid leukemia: a short review and a case report.

  2013cites this paper
• A dual-regulated oncolytic adenovirus expressing interleukin-24 sensitizes melanoma cells to temozolomide via the induction of apoptosis

  2013cites this paper
• DNA origami as a DNA repair nanosensor at the single-molecule level.

  2013cites this paper
• Reversing the Warburg Effect as a Treatment for Glioblastoma*

  2013cites this paper
• Chapter 10 – Management of Recurrent Gliomas

  2012cites this paper
• Down-regulation of the PTTG1 proto-oncogene contributes to the melanoma suppressive effects of the cyclin-dependent kinase inhibitor PHA-848125.

  2012cites this paper
• 19 – Management of recurrent gliomas and meningiomas

  2012cites this paper
• Temozolomide and radiotherapy in newly diagnosed glioblastoma patients: O6-methylguanine-DNA methyltransferase (MGMT) promotor methylation status and Ki-67 as biomarkers for survival and response to treatment

  2012cites this paper
• Circumventing melanoma chemoresistance by targeting DNA repair.

  2012cites this paper
• The Identification of a Novel Gene, MAPO2, That Is Involved in the Induction of Apoptosis Triggered by O6-Methylguanine

  2012cites this paper
• NF-κB is activated in response to temozolomide in an AKT-dependent manner and confers protection against the growth suppressive effect of the drug

  2012cites this paper
• Effect of temozolomide on cell viability in gonadotroph adenoma cell lines.

  2011cites this paper
• Development of a Novel Fluorescence Assay Based on the Use of the Thrombin-Binding Aptamer for the Detection of O6-Alkylguanine-DNA Alkyltransferase Activity

  2010cites this paper
• The use of temozolomide for the treatment of malignant tumors: clinical evidence and molecular mechanisms of action.

  2010cites this paper
• Placenta growth factor induces melanoma resistance to temozolomide through a mechanism that involves the activation of the transcription factor NF-κB.

  2010cites this paper
• The cyclin-dependent kinase inhibitor PHA-848125 suppresses the in vitro growth of human melanomas sensitive or resistant to temozolomide, and shows synergistic effects in combination with this triazene compound.

  2010cites this paper
• Inhibition of Poly(ADP-Ribose) Polymerase Enhances the Effect of Chemotherapy in an Animal Model of Regional Therapy for the Treatment of Advanced Extremity Malignant Melanoma

  2010cites this paper
• Genomic and Molecular Profiling Predicts Response to Temozolomide in Melanoma

  2009cites this paper
• Temozolomide- and fotemustine-induced apoptosis in human malignant melanoma cells: response related to MGMT, MMR, DSBs, and p53

  2009cites this paper
• ABT-888 Confers Broad In vivo Activity in Combination with Temozolomide in Diverse Tumors

  2009cites this paper
• A novel protein, MAPO1, that functions in apoptosis triggered by O6-methylguanine mispair in DNA

  2009cites this paper
• Concomitant activation of Wnt pathway and loss of mismatch repair function in human melanoma

  2008cites this paper
• Mecanismos de indução de apoptose pela presença de danos ao DNA: Um estudo sobre o papel de p53 na resistência de células de glioma a agentes quimioterápicos

  2008cites this paper
• Interleukin-24 overcomes temozolomide resistance and enhances cell death by down-regulation of O6-methylguanine-DNA methyltransferase in human melanoma cells

  2008cites this paper
• Carmustine-Resistant Cancer Cells Are Sensitized to Temozolomide As A Result of Enhanced Mismatch Repair during the Development of Carmustine Resistance

  2008cites this paper
• Mebendazole Induces Apoptosis via Bcl-2 Inactivation in Chemoresistant Melanoma Cells

  2008cites this paper
• Structure-Based Discovery of Novel Non-nucleosidic DNA Alkyltransferase Inhibitors: Virtual Screening and in Vitro and in Vivo Activities

  2008cites this paper
• Chemoresistant Melanoma Cells Mebendazole Induces Apoptosis via Bcl-2 Inactivation in

  2008cites this paper
• The PARP inhibitor, ABT-888 potentiates temozolomide: correlation with drug levels and reduction in PARP activity in vivo.

  2008cites this paper
• Lessons learned from DNA repair defective syndromes

  2007cites this paper
• Modes of actions of two types of anti-neoplastic drugs, dacarbazine and ACNU, to induce apoptosis.

  2007cites this paper
• Defining regional infusion treatment strategies for extremity melanoma: comparative analysis of melphalan and temozolomide as regional chemotherapeutic agents

  2007cites this paper
• Loss of the mismatch repair protein MSH6 in human glioblastomas is associated with tumor progression during temozolomide treatment.

  2007cites this paper
• Temozolomide induces senescence but not apoptosis in human melanoma cells

  2007cites this paper
• Combined effect of temozolomide and hyperthermia on human melanoma cell growth and O6-methylguanine-DNA methyltransferase activity.

  2007cites this paper
• Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine

  2007cites this paper
• Mechanisms of resistance to cisplatin and carboplatin.

  2007cites this paper
• MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents.

  2007cites this paper
• O6-Methylguanine-DNA-methyltransferase promoter demethylation is involved in basic fibroblast growth factor–induced resistance against temozolomide in human melanoma cells

  2007cites this paper
• Novel role of triazenes in haematological malignancies: pilot study of Temozolomide, Lomeguatrib and IL-2 in the chemo-immunotherapy of acute leukaemia.

  2007cites this paper
• MGMT: a personal perspective.

  2007cites this paper
• Loss of the Mismatch Repair Protein MSH6 in Human Glioblastomas Is Associated with Tumor Progression during Temozolomide Treatment

  2007cites this paper
• DNA Methylation Damage: Formation, Repair and Biological Consequences

  2007cites this paper
• O6‐methylguanine DNA methyltransferase and p53 status predict temozolomide sensitivity in human malignant glioma cells

  2006influential citation
• DNA damage-induced cell death by apoptosis.

  2006cites this paper
• TargetedModulation ofMGMT : Clinical Implications

  2006cites this paper
• Targeted Modulation of MGMT: Clinical Implications

  2006cites this paper
• A single cycle of treatment with temozolomide, alone or combined with O(6)-benzylguanine, induces strong chemoresistance in melanoma cell clones in vitro: role of O(6)-methylguanine-DNA methyltransferase and the mismatch repair system.

  2006cites this paper
• CHAPTER 6 – Chemotherapy Resistance

  2006cites this paper
• Recurrent glioblastoma multiforme: a review of natural history and management options.

  2006cites this paper
• DNA mismatch repair deficiency, resistance to cancer chemotherapy and the development of hypersensitive agents.

  2005cites this paper
• Phase I study of temozolomide plus paclitaxel in patients with advanced malignant melanoma and associated in vitro investigations

  2005cites this paper
• Chemotherapy, cytokines, and biochemotherapy for melanoma.

  2005cites this paper
• 518A2 Melanoma Cells Are Protected by G3139 and Other Antineoplastic Agents Against the Cytotoxic Effects of DTIC

  2005cites this paper
• CpG island hypermethylation of the DNA repair enzyme methyltransferase predicts response to temozolomide in primary gliomas.

  2005cites this paper
• Multidrug resistance in solid tumours

  2004cites this paper
• CpG Island Hypermethylation of the DNA Repair Enzyme Methyltransferase Predicts Response to Temozolomide in Primary Gliomas

  2004cites this paper
• Chemosensitization to Platinum-Based Anticancer Drugs

  2004cites this paper
• In vitro antitumour activity of resveratrol in human melanoma cells sensitive or resistant to temozolomide

  2004cites this paper
• Evaluation of Temozolomide in Patients with Myelodysplastic Syndrome

  2004cites this paper
• Biallelic somatic inactivation of the mismatch repair gene MLH1 in a primary skin melanoma

  2003cites this paper
• Temozolomide: realizing the promise and potential

  2003cites this paper
• Mécanisme d'action de la drogue anticancéreuse cis-dichlorodiammineplatine (II) : étude de l'interaction entre les protéines de réparation des mésappariements et l'ADN platiné

  2003cites this paper
• Cytotoxicity, DNA Damage, and Apoptosis Induced by New Fotemustine Analogs on Human Melanoma Cells in Relation to O6-Methylguanine DNA-Methyltransferase Expression

  2003cites this paper
• Xeroderma pigmentosum: the first of the cellular caretakers.

  2001cites this paper