Mixed inhibition of adenosine deaminase activity by 1,3-dinitrobenzene: a model for understanding cell-selective neurotoxicity in chemically-induced energy deprivation syndromes in brain.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Toxicological Sciences

• Publication date

  2012-02-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1093/toxsci/kfr317PMID 22106038PMCID PMC3262860
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Proteomic identification of carbonylated proteins in 1,3-dinitrobenzene neurotoxicity.

  2011cited by this paper
• 1,3-Dinitrobenzene-induced metabolic impairment through selective inactivation of the pyruvate dehydrogenase complex.

  2011cited by this paper
• Rapid determination of adenosine deaminase kinetics using fast-scan cyclic voltammetry.

  2010cited by this paper
• Hill coefficients, dose–response curves and allosteric mechanisms

  2010cited by this paper
• Adenosine and inosine release during hypoxia in the isolated spinal cord of neonatal rats

  2010cited by this paper
• Modulation and metamodulation of synapses by adenosine

  2010cited by this paper
• Adenosine receptors and neurological disease: neuroprotection and neurodegeneration.

  2009cited by this paper
• Conformational change of adenosine deaminase during ligand-exchange in a crystal.

  2008cited by this paper
• Nitro as a novel zinc-binding group in the inhibition of carboxypeptidase A.

  2008cited by this paper
• Human adenosine deaminase as an allosteric modulator of human A1 adenosine receptor: abolishment of negative cooperativity for [3H](R)‐pia binding to the caudate nucleus

  2008cited by this paper
• A study on the inhibition of adenosine deaminase.

  2008cited by this paper
• Adenosine, an endogenous distress signal, modulates tissue damage and repair

  2007cited by this paper
• Historical review: ATP as a neurotransmitter.

  2006cited by this paper
• Neurochemical and oedematous changes in 1,3-dinitrobenzene-induced astroglial injury in rat brain from a 1H-nuclear magnetic resonance perspective

  2006cited by this paper
• Purinergic transmission in the central nervous system

  2006cited by this paper
• Structural basis of compound recognition by adenosine deaminase.

  2005cited by this paper
• Actions of adenosine at its receptors in the CNS: insights from knockouts and drugs.

  2005cited by this paper
• Astrocytes and neurons: different roles in regulating adenosine levels

  2005cited by this paper
• Assessing scoring functions for protein-ligand interactions.

  2004cited by this paper
• Astrocytes in Acute Energy Deprivation Syndromes

  2004cited by this paper
• Making optimal use of empirical energy functions: Force‐field parameterization in crystal space

  2004cited by this paper
• High‐resolution real‐time recording with microelectrode biosensors reveals novel aspects of adenosine release during hypoxia in rat hippocampal slices

  2003cited by this paper
• A point‐charge force field for molecular mechanics simulations of proteins based on condensed‐phase quantum mechanical calculations

  2003cited by this paper
• Identification and prediction of promiscuous aggregating inhibitors among known drugs.

  2003cited by this paper
• 1,3-Dinitrobenzene inhibits mitochondrial complex II in rat and mouse brainstem and cortical astrocytes.

  2003cited by this paper
• 1,3-Dinitrobenzene metabolism and protein binding.

  2002cited by this paper
• The depth of chemical time and the power of enzymes as catalysts.

  2001cited by this paper
• Adenosine deaminase: Functional implications and different classes of inhibitors

  2001influential reference
• Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor

  2001cited by this paper
• Adenosine in the central nervous system: release mechanisms and extracellular concentrations

  2001influential reference
• Differential cellular regulation of the mitochondrial permeability transition in an in vitro model of 1,3-dinitrobenzene-induced encephalopathy.

  2000cited by this paper
• Cis peptide bonds in proteins: residues involved, their conformations, interactions and locations.

  1999cited by this paper
• Pharmacokinetic factors and concentration-time threshold in m-dinitrobenzene-induced neurotoxicity.

  1999cited by this paper
• One‐Dimensional Electrophoresis Using Nondenaturing Conditions

  1999cited by this paper
• Unsupervised Data Base Clustering Based on Daylight's Fingerprint and Tanimoto Similarity: A Fast and Automated Way To Cluster Small and Large Data Sets

  1999cited by this paper
• Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function

  1998cited by this paper
• Capacity of rat brain to metabolize m-dinitrobenzene: an in vitro study.

  1997cited by this paper
• One‐Dimensional Electrophoresis Using Nondenaturing Conditions

  1995cited by this paper
• Early metabolic changes during m-Dinitrobenzene neurotoxicity and the possible role of oxidative stress.

  1995cited by this paper
• Inhibition of adenosine kinase increases endogenous adenosine and depresses neuronal activity in hippocampal slices.

  1994cited by this paper
• The rate of formation of transition-state analogues in the active site of adenosine deaminase is encounter-controlled: implications for the mechanism.

  1992cited by this paper
• Effect of culture age on 1,3-dinitrobenzene metabolism and indicators of cellular toxicity in rat testicular cells.

  1991cited by this paper
• A comparison of the effects of the three isomers of dinitrobenzene on the testis in the rat.

  1988cited by this paper
• 1,3‐DINITROBENZENE‐INDUCED ENCEPHALOPATHY IN RATS

  1987cited by this paper
• Transition-state stabilization by adenosine deaminase: structural studies of its inhibitory complex with deoxycoformycin.

  1986cited by this paper
• Blood volume in the rat.

  1985cited by this paper
• 1,3-dinitrobenzene: toxic effects in vivo and in vitro.

  1981cited by this paper
• Induction of hepatic and testicular lesions in Fischer-344 rats by single oral doses of nitrobenzene.

  1981cited by this paper
• MAXIMUM ACTIVITIES, PROPERTIES AND DISTRIBUTION OF 5’NUCLEOTIDASE, ADENOSINE KINASE AND ADENOSINE DEAMINASE IN RAT AND HUMAN BRAIN

  1979cited by this paper
• [69] Specific adenosine deaminase from intestine

  1955cited by this paper

• Mixed and non-competitive enzyme inhibition: underlying mechanisms and mechanistic irrelevance of the formal two-site model

  2023cites this paper
• Catalytically active holo Homo sapiens adenosine deaminase I adopts a closed conformation.

  2022cites this paper
• 1,3-Dinitrobenzene neurotoxicity - Passage effect in immortalized astrocytes.

  2016cites this paper
• The role of astrocyte mitochondria in differential regional susceptibility to environmental neurotoxicants: tools for understanding neurodegeneration.

  2015cites this paper
• Role of Age in Mitochondrial Susceptibility to 1,3-Dinitrobenzene-Induced Neurotoxicity.

  2014cites this paper
• Inhibitory mechanism of dimercaptopropanesulfonic acid (DMPS) in the cellular biomethylation of arsenic.

  2014cites this paper
• A comparative study of protein carbonylation and mitochondrial dysfunction using the neurotoxicants 1,3-dinitrobenzene, 3-nitropropionic acid, and 3-chloropropanediol.

  2013cites this paper
• The Investigation on the Mechanism of Neuroprotection by Adenosine in 1,3-Dinitrobenzene Toxicity.

  2012cites this paper