Rapid degradation of cyclooxygenase-1 and hematopoietic prostaglandin D synthase through ubiquitin–proteasome system in response to intracellular calcium level

Misato Yazaki,K. Kashiwagi,K. Aritake,Y. Urade,K. Fujimori

Published 2012 in Molecular Biology of the Cell

ABSTRACT

Cyclooxygenase-1 and hematopoietic prostaglandin D synthase proteins were rapidly degraded within 30 and 60 min, respectively, after an increase in the intracellular calcium level in human megakaryocytic MEG-01 cells.

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