A possible role for membrane depolarization in epithelial wound healing.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  American Journal of Physiology - Cell Physiology

• Publication date

  2005-06-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1152/AJPCELL.00259.2004PMID 15897322
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2004influential reference
• Intracellular [Na+], Na+ pathways, and fluid transport in cultured bovine corneal endothelial cells.

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  2002influential reference
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• Intracellular signaling pathway of FGF-2-modulated corneal endothelial cell migration during wound healing in vitro.

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• Modeling cell volume regulation in nonexcitable cells: the roles of the Na+ pump and of cotransport systems.

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• Physiological electrical fields modify cell behaviour.

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• The responses of cells to electrical fields: a review

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