Nonsteroidal anti-inflammatory drugs, acetaminophen, cyclooxygenase 2, and fever.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Clinical Infectious Diseases

• Publication date

  2000-10-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1086/317517PMID 11113025
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cyclooxygenase‐2 inhibition by rofecoxib reverses naturally occurring fever in humans

  1999cited by this paper
• Inhibition of prostaglandin synthesis up-regulates cyclooxygenase-2 induced by lipopolysaccharide and peroxisomal proliferators.

  1999cited by this paper
• Regulation of cytosolic COX-2 and prostaglandin E2 production by nitric oxide in activated murine macrophages.

  1999cited by this paper
• Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles.

  1999cited by this paper
• Cyclooxygenase-2: molecular biology, pharmacology, and neurobiology.

  1999cited by this paper
• The Role of Arginine 120 of Human Prostaglandin Endoperoxide H Synthase-2 in the Interaction with Fatty Acid Substrates and Inhibitors*

  1999cited by this paper
• The febrile response to lipopolysaccharide is blocked in cyclooxygenase-2(-/-), but not in cyclooxygenase-1(-/-) mice.

  1999cited by this paper
• The discovery of rofecoxib, [MK 966, Vioxx, 4-(4'-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2-inhibitor.

  1999cited by this paper
• Induction of an acetaminophen-sensitive cyclooxygenase with reduced sensitivity to nonsteroid antiinflammatory drugs.

  1999cited by this paper
• Fever: links with an ancient receptor.

  1999cited by this paper
• Kinetic basis for selective inhibition of cyclo-oxygenases.

  1999cited by this paper
• Cyclooxygenase 2 mRNA expression in rat brain after peripheral injection of lipopolysaccharide.

  1998cited by this paper
• Cyclooxygenase-2 is induced in brain blood vessels during fever evoked by peripheral or central administration of tumor necrosis factor.

  1998cited by this paper
• Brain Endothelial Cells Express Cyclooxygenase-2 during Lipopolysaccharide-Induced Fever: Light and Electron Microscopic Immunocytochemical Studies

  1998cited by this paper
• Expression of mRNAs for vasopressin, oxytocin and corticotrophin releasing hormone in the hypothalamus, and of cyclooxygenases-1 and -2 in the cerebral vasculature, of endotoxin-challenged pigs.

  1998cited by this paper
• Comparison of the antipyretic actions of indomethacin and L-745,337, a selective cyclooxygenase-2 inhibitor, in endotoxin-treated prepubertal pigs.

  1998cited by this paper
• Neurobiological Basis of Fever

  1998influential reference
• Prostaglandin E2 in the Pathogenesis of Fever: An Update a

  1998cited by this paper
• Afferent Pathways of Pyrogen Signaling a

  1998cited by this paper
• Resveratrol Inhibits Cyclooxygenase-2 Transcription and Activity in Phorbol Ester-treated Human Mammary Epithelial Cells*

  1998cited by this paper
• Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3

  1998cited by this paper
• Paradoxical effects of resveratrol on the two prostaglandin H synthases.

  1998cited by this paper
• Induction of Cyclooxygenase‐2 in the Brain by Cytokines

  1997cited by this paper
• Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX‐2 inhibitor

  1997cited by this paper
• Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents

  1997cited by this paper
• The effects of a newly developed nonsteroidal anti-inflammatory drug (M-5011) on arachidonic acid metabolism in rheumatoid synovial fibroblasts.

  1997cited by this paper
• Blockade of Kupffer Cells Prevents the Febrile and Preoptic Prostaglandin E2 Responses to Intravenous Lipopolysaccharide in Guinea Pigs a

  1997cited by this paper
• Inhibition of brain cyclooxygenase-2 activity and the antipyretic action of nimesulide.

  1997cited by this paper
• NSAID-induced apoptosis in Rous sarcoma virus-transformed chicken embryo fibroblasts is dependent on v-src and c-myc and is inhibited by bcl-2.

  1997cited by this paper
• Peroxisome Proliferator-activated Receptors α and γ Are Activated by Indomethacin and Other Non-steroidal Anti-inflammatory Drugs*

  1997cited by this paper
• Epidermal growth factor receptor activation induces nuclear targeting of cyclooxygenase-2, basolateral release of prostaglandins, and mitogenesis in polarizing colon cancer cells.

  1997cited by this paper
• Intravenous lipopolysaccharide induces cyclooxygenase 2‐like immunoreactivity in rat brain perivascular microglia and meningeal macrophages

  1997cited by this paper
• Involvement of cyclooxygenase-2 in LPS-induced fever and regulation of its mRNA by LPS in the rat brain.

  1997cited by this paper
• Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs.

  1997cited by this paper
• Induction of Cyclooxygenase-2 Expression by Peroxisome Proliferators and Non-tetradecanoylphorbol 12,13-Myristate-type Tumor Promoters in Immortalized Mouse Liver Cells*

  1997cited by this paper
• A selective inhibitor of cyclooxygenase-2 reverses endotoxin-induced pyretic responses in non-human primates.

  1997cited by this paper
• Flexibility of the NSAID binding site in the structure of human cyclooxygenase-2

  1996cited by this paper
• Prostaglandin endoperoxide H synthases-1 and -2.

  1996cited by this paper
• Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents

  1996cited by this paper
• Prostaglandin synthase 2.

  1996cited by this paper
• C-terminal Ser/Pro-Thr-Glu-Leu tetrapeptides of prostaglandin endoperoxide H synthases-1 and -2 target the enzymes to the endoplasmic reticulum.

  1996cited by this paper
• Induction of cyclooxygenase and nitric oxide synthase in endotoxin-activated J774 macrophages is differentially regulated by indomethacin: enhanced cyclooxygenase-2 protein expression but reduction of inducible nitric oxide synthase.

  1996cited by this paper
• Blockade of lipopolysaccharide-induced fever by subdiaphragmatic vagotomy in guinea pigs.

  1996cited by this paper
• Expression of inducible cyclooxygenase mRNA in the mouse brain after systemic administration of bacterial lipopolysaccharide.

  1996cited by this paper
• Endothelial cells of the rat brain vasculature express cyclooxygenase-2 mRNA in response to systemic interleukin-1 beta: a possible site of prostaglandin synthesis responsible for fever.

  1996cited by this paper
• The structural basis of aspirin activity inferred from the crystal structure of inactivated prostaglandin H2 synthase

  1995cited by this paper
• Pharmacology of a selective cyclooxygenase-2 inhibitor, L-745,337: a novel nonsteroidal anti-inflammatory agent with an ulcerogenic sparing effect in rat and nonhuman primate stomach.

  1995cited by this paper
• Blockade of interleukin-1 induced hyperthermia by subdiaphragmatic vagotomy: evidence for vagal mediation of immune-brain communication.

  1995cited by this paper
• Induction by lipopolysaccharide of cyclooxygenase-2 mRNA in rat brain; its possible role in the febrile response.

  1995cited by this paper
• Nonsteroidal antiinflammatory drugs cause apoptosis and induce cyclooxygenases in chicken embryo fibroblasts.

  1995cited by this paper
• Anti-inflammatory, analgesic, antipyretic and related properties of meloxicam, a new non-steroidal anti-inflammatory agent with favourable gastrointestinal tolerance

  1995cited by this paper
• The Discovery of Drugs to Treat Arthritis: A Historical View

  1995cited by this paper
• Towards a better aspirin

  1994cited by this paper
• Anti-inflammatory effects of etodolac: comparison with other non-steroidal anti-inflammatory drugs.

  1994cited by this paper
• The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1

  1994cited by this paper
• Aspirin and Other Salicylates

  1993cited by this paper
• Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase.

  1993cited by this paper
• Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.

  1991cited by this paper
• TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue.

  1991cited by this paper
• A serum- and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein.

  1991cited by this paper
• Anti-inflammatory and safety profile of DuP 697, a novel orally effective prostaglandin synthesis inhibitor.

  1990cited by this paper
• History of Aspirin and Its Mechanism of Action

  1990cited by this paper
• Identification of a phorbol ester-repressible v-src-inducible gene.

  1989cited by this paper
• Eicosanoid metabolism in cerebromicrovascular endothelium.

  1988cited by this paper
• Goodman and Gilman's The Pharmacological Basis of Therapeutics

  1986cited by this paper
• The Pharmacological Basis of Therapeutics

  1976cited by this paper
• Structural requirements for time-dependent inhibition of prostaglandin biosynthesis by anti-inflammatory drugs.

  1975cited by this paper
• Inhibition of Prostaglandin Synthetase in Brain explains the Anti-pyretic Activity of Paracetamol (4-Acetamidophenol)

  1972cited by this paper
• Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.

  1971cited by this paper

• Depression of tryptophan may contribute to adverse effects of naproxen.

  2026cites this paper
• The Chemistry and Bioactivity of Mefenamic Acid Derivatives: A Review of Recent Advances

  2025cites this paper
• Comparative Impact of NSAIDs Versus Acetaminophen on Mortality in Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: A Retrospective Cohort Study of 2484 Patients From a Nationwide Inpatient Database

  2025cites this paper
• Biocompatible New Coumarins as Dual-Target Anti-Inflammatory Agents: Insights from Chemistry to Toxicity

  2025cites this paper
• Enhanced collagen deposition in chondrogenic inflammation with Ibuprofen-specifically loaded chitosan/poly-gamma-glutamic acid nanoparticles.

  2025cites this paper
• TEMPORARY REMOVAL: Pharmacokinetics and postoperative analgesic efficacy of intravenous acetaminophen in dogs undergoing laparoscopic ovariohysterectomy

  2025cites this paper
• The dose-response effects of flurbiprofen, indomethacin, ibuprofen, and naproxen on primary skeletal muscle cells

  2024cites this paper
• Therapeutic Efficacy of Medicinal Plants with Allopathic Medicine in Musculoskeletal Diseases

  2024cites this paper
• Metabolomic Response to Non-Steroidal Anti-Inflammatory Drugs

  2024cites this paper
• Metabolomic Response to Non-Steroidal Anti-Inflammatory Drugs

  2024cites this paper
• Ultrasound-assisted magnetic dispersive micro-solid-phase extraction based on carbon quantum dots/zeolite imidazolate framework-90/polyvinyl pyrrolidone/Fe3O4 followed by high-performance liquid chromatography with ultraviolet detection for trace analysis of paracetamol and etodolac in human plasma

  2024cites this paper
• Two Birds with One Stone: Drug Regime Targets Viral Pathogenesis Phases and COVID-19 ARDS at the Same Time.

  2024cites this paper
• Investigation on the antipyretic mechanism of Chaiqin Qingning capsule for the treatment of fever based on network pharmacology, molecular docking, and in vitro experimental validation

  2024cites this paper
• Exploring in vitro and in vivo anti-inflammatory activities of the Thai traditional remedy Kheaw-Hom and its bioactive compound, ethyl p-methoxycinnamate, and ethnopharmacological analysis.

  2023cites this paper
• Direct Utilization of Expired Waste Acetaminophen as Organic Anode in Lithium‐Ion Batteries

  2023cites this paper
• Sublethal effects of acetaminophen exposure on benthic aquatic animal (Hydra magnipapillata)

  2023cites this paper
• Chalcones as Potential Cyclooxygenase-2 Inhibitors: A Review.

  2023cites this paper
• Impact and Possible Mechanism(s) of Adipose Tissue-Derived Mesenchymal Stem Cells on T-Cell Proliferation in Patients With Rheumatic Disease

  2022cites this paper
• A computational study on acetaminophen drug complexed with Mn+, Fe2+, Co+, Ni2+, and Cu+ ions: structural analysis, electronic properties, and solvent effects

  2022cites this paper
• Synthesis of PVA capped naproxen conjugated MgO nanoparticles and its bioactivity screening

  2022cites this paper
• Fever and breast cancer: A critical review of the literature and possible underlying mechanisms

  2021cites this paper
• Aspirin use and platelet aggregation in ischemic onset-type pediatric moyamoya patients with intractable headaches (moya-ache)

  2021cites this paper
• RHEUMATOID ARTHRITIS: ETIOPATHOGENESIS AND MOLECULAR BASIS

  2021cites this paper
• Identification and HPLC Purification of Aspirin (Acetylsalicylic Acid) from the Seed Coats, Leaves and Bark of Givotia Rottleriformis Griff.

  2021cites this paper
• Pharmacological hypotheses: Is acetaminophen selective in its cyclooxygenase inhibition?

  2021cites this paper
• Pt-doped boron carbide monolayer nanosheet as a work function-type sensor for ibuprofen drug: quantum chemical study

  2021cites this paper
• Antipyretic effect of ethanol extract of plant leaves of garden croton (Codiaeum variegatum) in male mice

  2021cites this paper
• One-Pot Multicomponent Synthesis and Bioevaluation of Tetrahydroquinoline Derivatives as Potential Antioxidants, α-Amylase Enzyme Inhibitors, Anti-Cancerous and Anti-Inflammatory Agents

  2020cites this paper
• Eliminating Opioid Dependency by Knowing the APTA (Anatomy,Pathophysiology, Treatment, and Assessment) of Pain

  2020cites this paper
• Ethnobotanical study of selected medicinal plants traditionally used in the rural Greater Mpigi region of Uganda.

  2020cites this paper
• Analysis of genetically determined gene expression suggests role of inflammatory processes in exfoliation syndrome

  2020cites this paper
• Analysis of Genetically Determined Gene Expression Suggests Role of Inflammatory Processes in Etiology of Exfoliation Syndrome

  2020cites this paper
• Cu(II) complexes of hydrazones–NSAID conjugates: synthesis, characterization and anticancer activity

  2020cites this paper
• One-pot multicomponent synthesis of novel 3, 4-dihydro-3-methyl-2(1H)-quinazolinone derivatives and their biological evaluation as potential antioxidants, enzyme inhibitors, antimicrobials, cytotoxic and anti-inflammatory agents

  2020cites this paper
• COVID-19 and the dental profession: Establishing a safe dental practice for the coronavirus era

  2020cites this paper
• A density functional theory evaluation on silicon doped boron nitride nanocones: ibuprofen drug sensing characterisation

  2020cites this paper
• Valproic Acid in Prevention and Treatment of COVID-19

  2020cites this paper
• Acetaminophen inhibits the neutrophil oxidative burst: implications for diagnostic testing.

  2020cites this paper
• Relative Expression of Mouse Udp-Glucuronosyl Transferase 2b1 Gene in The Livers, Kidneys, And Hearts: The Influence of Nonsteroidal Anti-Inflammatory Drug Treatment.

  2019cites this paper
• Acetaminophen use during pregnancy and DNA methylation in the placenta of the extremely low gestational age newborn (ELGAN) cohort

  2019cites this paper
• American Society of Plastic Surgeons Member Post-Operative Opioid Prescribing Patterns

  2019cites this paper
• Serum and Fecal Oxylipins in Patients with Alcohol-Related Liver Disease

  2019cites this paper
• The Use of Analgesics during Vaccination with a Live Attenuated Yersinia pestis Vaccine Alters the Resulting Immune Response in Mice

  2019cites this paper
• Synthesis, characterization and evaluation of novel benzothiazole clubbed chromene derivatives for their anti-inflammatory potential

  2018cites this paper
• An advanced approach for electrochemical sensing of ibuprofen in pharmaceuticals and human urine samples using a bare boron-doped diamond electrode

  2018cites this paper
• Using human iPS cell-derived enterocytes as novel in vitro model for the evaluation of human intestinal mucosal damage

  2018cites this paper
• Randomized open-label [corrected] non-inferiority trial of acetaminophen or loxoprofen for patients with acute low back pain.

  2018cites this paper
• Comparison of Efficacy of Diclofenac and Paracetamol as Preemptive Analgesic Agent

  2018cites this paper
• Alleviating Promotion of Inflammation and Cancer Induced by Nonsteroidal Anti-Inflammatory Drugs

  2017cites this paper
• The Effects of Thai Herbal Ha-Rak Formula on COX Isoform Expression in Human Umbilical Vein Endothelial Cells Induced by IL-1β

  2017cites this paper
• Sigma-1 receptors control immune-driven peripheral opioid analgesia during inflammation in mice

  2017cites this paper
• The influence of non-steroidal anti-inflammatory drugs and paracetamol used for pain control of orthodontic tooth movement: a systematic review.

  2017cites this paper
• Design Development and Evaluation of Transdermal Drug Delivery System of Antipyretic Agent

  2017cites this paper
• In Vivo Efficacy of Latex from Calotropis procera in Ameliorating Fever—Biochemical Characteristics and Plausible Mechanism

  2017cites this paper
• Nonsteroidal Anti-inflammatory Drugs (NSAIDs) and Corticosteroids

  2016cites this paper
• Combination of Paracetamol and the Glutathione Depleting Agent Buthionine Sulfoximine Show Differential Effect on Liver Cancer Cells and Normal Hepatocytes

  2016cites this paper
• Cometabolic Degradation of Anti-Inflammatory and Analgesic Pharmaceuticals by a Pentane Enrichment Culture

  2016influential citation
• Cocaine-Induced Agitated Delirium

  2015cites this paper
• Effects of paracetamol and etodolac on plasma adrenaline levels of rats

  2014cites this paper
• Simultaneous Determination of Some Analgesic Drugs Using Mixed Mode Stationary Phase

  2013cites this paper
• EMOTION-COGNITION INTERACTIONS; A STUDY ON COPING RESPONSES OF METHAMPHETAMINE DEPENDENT WOMEN

  2011cites this paper
• Estudo das Atividades Anti-inflamatória e Antinociceptiva dos Derivados Indol-imidazolidínicos 5-(1H-Indol-3-il-metileno)-2-tioxo-imidazolidin-4- ona (LPSF/NN-56) e 3-(4-Bromo-benzil)-5-(1H-indol-3-il-metileno)-2- tioxo-imidazolidin-4-ona(LPSF/NN-52)

  2011cites this paper
• Inhibition of Cyclooxygenase Type 1 and 2 Enzyme by Aqueous Extract of Elaeagnus Angustifolia in Mice

  2011cites this paper
• Evaluation of the molecular and HPLC retention data of analgesic and anti-inflammatory drugs by factor analysis in view of their pharmacological activity

  2011cites this paper
• EFFECT OF AQUEOUS EXTRACT OF TRIGONELLA FOENUM-GRAECUM ON PAIN AND INFLAMMATION INDUCED BY FORMALIN IN MALE MICE

  2011influential citation
• Nonsteroidal Antiinflammatory Agents

  2011cites this paper
• Treatment of experimental amyloidosis with antirheumatic drugs

  2010cites this paper
• Treatment of experimental amyloidosis with antirheumatic drugs@@@Eksperimentinės amiloidozės gydymas priešreumatiniais vaistais

  2010cites this paper
• Approach to the Febrile Patient in the Intensive Care Unit

  2010cites this paper
• Atividade antipirética e antiinflamatória de derivados 5-trifluormetil-4,5-diidro-1H-1-carboxiamida pirazol em ratos

  2010cites this paper
• Increased mitochondrial stress and modulation of mitochondrial respiratory enzyme activities in acetaminophen-induced toxicity in mouse macrophage cells.

  2010cites this paper
• Acetaminophen-induced Mitochondrial Oxidative Stress in Murine J774.2 Monocyte Macrophages

  2010cites this paper
• Evaluation of molecular descriptors and HPLC retention data of analgesic and anti-inflammatory drugs by factor analysis in relation to their pharmacological activity

  2010cites this paper
• Approach to the febrile patient in the ICU.

  2009cites this paper
• Opioid, cannabinoid CB1 and NOP receptors do not mediate APAP-induced hypothermia in rats.

  2009cites this paper
• COX-3: Uncertainties and controversies

  2009cites this paper
• Avaliação histométrica do reparo ósseo alveolar de ratos tratados com anti-inflamatórios não-esteroidais

  2009cites this paper
• Effects of Antirheumatic Drugs on the Development of Experimental AA Amyloidosis in C57BL/6 Mice

  2009cites this paper
• When the child has a fever

  2008cites this paper
• Acetaminophen: antipyretic or hypothermic in mice? In either case, PGHS-1b (COX-3) is irrelevant.

  2008cites this paper
• Exercise can be pyrogenic in humans.

  2007cites this paper
• Physiology and Pharmacology of Temperature Regulation Exercise can be pyrogenic in humans

  2006cites this paper
• Pediatric Fever: Myths and Management

  2005cites this paper
• Interrelationships between aromatase and cyclooxygenase-2 and their role in the autocrine and paracrine mechanisms in breast cancer

  2005cites this paper
• The effects of drugs on thermoregulation.

  2004cites this paper
• Review Clinical review: Fever in intensive care unit patients

  2003cites this paper
• The development of COX2 inhibitors

  2003cites this paper
• Paracetamol effectively reduces prostaglandin E2 synthesis in brain macrophages by inhibiting enzymatic activity of cyclooxygenase but not phospholipase and prostaglandin E synthase

  2003cites this paper
• The prospective use of COX-2 inhibitors for the treatment of temporomandibular joint inflammatory disorders.

  2003cites this paper
• Expression of genes controlling transport and catabolism of prostaglandin E2 in lipopolysaccharide fever.

  2003cites this paper
• Clinical review: Fever in intensive care unit patients

  2003cites this paper
• Cytokines and Appetite

  2003cites this paper
• Reciprocal products of chromosomal translocations in human cancer pathogenesis: key players or innocent bystanders?

  2002cites this paper
• Prostanoids and pain: unraveling mechanisms and revealing therapeutic targets.

  2002cites this paper
• Disseminated Microsporidiosis Caused by Encephalitozoon cuniculi III (Dog Type) in an Italian AIDS Patient: a Retrospective Study

  2002cites this paper
• Differential Inhibition by Nimesulide of the Early and Late Phases of Intravenous- and Intracerebroventricular-LPS-Induced Fever in Guinea Pigs

  2002cites this paper
• Prostaglandin E(2)-synthesizing enzymes in fever: differential transcriptional regulation.

  2002cites this paper
• Nonsteroid Anti-Inflammatory Drugs Inhibit Both the Activity and the Inflammation-Induced Expression of Acid-Sensing Ion Channels in Nociceptors

  2001cites this paper
• COMMENT Skeletal Muscle PGF2 and PGE2 in Response to Eccentric Resistance Exercise: Influence of Ibuprofen and Acetaminophen

  2001cites this paper
• Skeletal muscle PGF(2)(alpha) and PGE(2) in response to eccentric resistance exercise: influence of ibuprofen acetaminophen.

  2001cites this paper