Agglutinin response, a function of cell number.

Our in vivo culture studies revealed that, independent of a) the strain of mice; b) the type of particulate antigen; c) the time of bleeding after cell transfer and antigen injection; and d) whether animals were undergoing a primary or secondary antibody response, a linear log2 antibody titer log2 nucleated cell relation was obtained with spleen and peritoneal exudate cells. Furthermore, the slopes of the resulting regression lines for the primary and secondary responses did not differ significantly, but the antibody-forming activity per given number of nucleated cells was significantly greater in the secondary antibody response than in the primary antibody response. The optimum dose of RBC for a maximum sensitization was 1 ml of 1%, and no difference between intravenous and intraperitoneal routes of RBC injection was noted.

• Publication year

  1961

• Venue

  Journal of Immunology

• Publication date

  1961-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.86.5.533PMID 13734391
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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