Update on the ongoing outbreak of haemolytic uraemic syndrome due to Shiga toxin-producing Escherichia coli (STEC) serotype O104, Germany, May 2011.

Since early May 2011, a large outbreak of haemolytic uraemic syndrome (HUS) and bloody diarrhoea related to infections with Shiga toxin-producing Escherichia coli (STEC) has been observed in Germany. The outbreak is focused in the north, but cases have been reported from all German states and other countries. Since our report last week, the number of HUS cases has increased to 470 and STEC serotype O104 has been confirmed in many cases.

• Publication year

  2011

• Venue

  Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

• Publication date

  2011-06-02

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.2807/ESE.16.22.19883-ENPMID 21663710
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2011influential reference
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  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2009cited by this paper
• Clonal spread of KPC-2 carbapenemase-producing Klebsiella pneumoniae strains in Greece.

  2009cited by this paper
• The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria.

  2009influential reference
• Surveillance of lower respiratory tract infections outbreaks in nursing homes in France

  2009cited by this paper
• RAISIN - a national programme for early warning, investigation and surveillance of healthcare-associated infection in France.

  2009cited by this paper
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  2009cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2007cited by this paper
• Clostridium difficile in the long-term care setting.

  2007cited by this paper
• Extended-Spectrum β-Lactamases and Clinical Outcomes: Current Data

  2006cited by this paper
• VEB-1 Extended-Spectrum β-lactamase–producing Acinetobacter baumannii, France

  2006cited by this paper
• Extended-spectrum beta-lactamases and clinical outcomes: current data.

  2006cited by this paper
• First outbreak of multidrug-resistant Klebsiella pneumoniae carrying blaVIM-1 and blaSHV-5 in a French university hospital.

  2006cited by this paper
• Emergence of Clostridium difficile toxinotype III, PCR-ribotype 027-associated disease, France, 2006.

  2006cited by this paper
• Risk groups for clinical complications of norovirus infections: an outbreak investigation.

  2006cited by this paper
• A Case of Hemolytic Uremic Syndrome Caused by Escherichia coli O104:H4

  2006cited by this paper
• Rhinovirus Outbreak in a Long Term Care Facility for Elderly Persons Associated with Unusually High Mortality

  2005cited by this paper
• Increase in viral gastroenteritis outbreaks in Europe and epidemic spread of new norovirus variant.

  2004cited by this paper
• Detection and control of influenza outbreaks in well-vaccinated nursing home populations.

  2004cited by this paper
• Infectious disease outbreaks in nursing homes: an unappreciated hazard for frail elderly persons.

  2003cited by this paper
• Influenza vaccine effectiveness among elderly nursing home residents: a cohort study.

  2001cited by this paper
• Novel Carbapenem-Hydrolyzing β-Lactamase, KPC-1, from a Carbapenem-Resistant Strain of Klebsiella pneumoniae

  2001cited by this paper
• Surveillance for outbreaks of respiratory tract infections in nursing homes.

  2000cited by this paper
• Control of Influenza in the Long-Term–Care Facility: A Review of Established Approaches and Newer Options

  2000cited by this paper
• [Antibiogram Committee of the French Society for Microbiology. Official Statement 1999].

  1999cited by this paper
• Outbreak of Pneumonia in a Long‐term Care Facility: Antecedent Human Parainfluenza Virus 1 Infection May Predispose to Bacterial Pneumonia

  1998cited by this paper
• A study of the impact of influenza on the functional status of frail older people.

  1998cited by this paper
• Recognizing and controlling respiratory disease outbreaks in long-term care facilities

  1997cited by this paper
• Recognizing and controlling respiratory disease outbreaks in long-term care facilities.

  1997cited by this paper
• Outbreak Investigations

  1997cited by this paper
• Hospitalization of Nursing Home Residents: A Review of the Literature, 1980-1995

  1996cited by this paper
• Diarrhea Among Residents of Long-Term Care Facilities

  1993cited by this paper
• An efficient program for computing conditional maximum likelihood estimates and exact confidence limits for a common odds ratio.

  1991cited by this paper
• Definitions of infection for surveillance in long-term care facilities.

  1991cited by this paper
• Foodborne disease outbreaks in nursing homes, 1975 through 1987.

  1991cited by this paper
• Risk factors for outbreaks of influenza in nursing homes. A case-control study.

  1986cited by this paper
• Epidemiologic Analysis with a Programmable Calculator

  1982cited by this paper
• Impact of influenza A in a nursing home.

  1982cited by this paper

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  2011cites this paper
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  2011cites this paper
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  2011cites this paper
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  2011cites this paper