Multiple Molecular Pathways Are Involved in the Neuroprotection of GDNF Against Proteasome Inhibitor Induced Dopamine Neuron Degeneration In Vivo

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Experimental biology and medicine

• Publication date

  2008-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3181/0712-RM-329PMID 18445767
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Unbiased morphological measurements show no neuronal loss in the substantia nigra in Alzheimer's disease

  2014cited by this paper
• Glial cell-derived neurotrophic factor protects against proteasome inhibition-induced dopamine neuron degeneration by suppression of endoplasmic reticulum stress and caspase-3 activation.

  2007cited by this paper
• GDNF reduces oxidative stress in a 6-hydroxydopamine model of Parkinson's disease.

  2007cited by this paper
• Mitogen-activated protein kinases, Erk and p38, phosphorylate and regulate Foxo1.

  2007cited by this paper
• Different Species of α-Synuclein Oligomers Induce Calcium Influx and Seeding

  2007cited by this paper
• Different species of alpha-synuclein oligomers induce calcium influx and seeding.

  2007cited by this paper
• Activation of c-Jun N-terminal protein kinase is a common mechanism underlying paraquat- and rotenone-induced dopaminergic cell apoptosis.

  2007cited by this paper
• Proteasome inhibitor lactacystin disturbs the intracellular calcium homeostasis of dopamine neurons in ventral mesencephalic cultures.

  2007cited by this paper
• PAN-811 provides neuroprotection against glutamate toxicity by suppressing activation of JNK and p38 MAPK.

  2007cited by this paper
• GDNF applied to the MPTP-lesioned nigrostriatal system requires TGF-beta for its neuroprotective action.

  2007influential reference
• Molecular basis of neurodegenerative diseases.

  2006cited by this paper
• LRRK2 protein is a component of lewy bodies

  2006cited by this paper
• Understanding the molecular causes of Parkinson's disease.

  2006cited by this paper
• Dynamic modeling of alpha-synuclein aggregation for the sporadic and genetic forms of Parkinson's disease.

  2006cited by this paper
• Interplay between PI3K/Akt and MAPK signaling pathways in DNA-damaging drug-induced apoptosis.

  2006cited by this paper
• Randomized controlled trial of intraputamenal glial cell line–derived neurotrophic factor infusion in Parkinson disease

  2006cited by this paper
• p53 Mediates Nontranscriptional Cell Death in Dopaminergic Cells in Response to Proteasome Inhibition*

  2006cited by this paper
• Ubiquitin–proteasome system and Parkinson's disease

  2006cited by this paper
• Point source concentration of GDNF may explain failure of phase II clinical trial.

  2006cited by this paper
• Lewy bodies.

  2006cited by this paper
• Glial-derived neurotrophic factor (GDNF) prevents ethanol (EtOH) induced B92 glial cell death by both PI3K/AKT and MEK/ERK signaling pathways.

  2006cited by this paper
• Proteasome inhibition and Parkinson's disease modeling

  2006cited by this paper
• The complexity of p53 stabilization and activation

  2006cited by this paper
• Brain-derived growth factor and glial cell line-derived growth factor use distinct intracellular signaling pathways to protect PD cybrids from H2O2-induced neuronal death.

  2005cited by this paper
• Lewy bodies in Parkinson's disease: protectors or perpetrators?

  2005cited by this paper
• Stepholidine protects against H2O2 neurotoxicity in rat cortical neurons by activation of Akt.

  2005cited by this paper
• Neuroprotection by iron chelator against proteasome inhibitor-induced nigral degeneration.

  2005cited by this paper
• Effects of 6‐hydroxydopamine on primary cultures of substantia nigra: specific damage to dopamine neurons and the impact of glial cell line‐derived neurotrophic factor

  2004cited by this paper
• Minocycline prevents glutamate‐induced apoptosis of cerebellar granule neurons by differential regulation of p38 and Akt pathways

  2004cited by this paper
• The Role of Ubiquitin-Protein Ligases in Neurodegenerative Disease

  2004cited by this paper
• The mouse brain in stereotaxic coordinates

  2003cited by this paper
• Angiopoietin‐1‐induced phosphatidyl‐inositol 3‐kinase activation prevents neuronal apoptosis

  2003cited by this paper
• Neuroprotective and restorative effects of intrastriatal grafting of encapsulated GDNF-producing cells in a rat model of Parkinson's disease

  2003cited by this paper
• Neuroprotective and restorative effects of intrastriatal grafting of encapsulated GDNF‐producing cells in a rat model of Parkinson's disease

  2002cited by this paper
• Selenite suppresses hydrogen peroxide‐induced cell apoptosis through inhibition of ASK1/JNK and activation of PI3‐K/Akt pathways

  2002cited by this paper
• Impairment of the ubiquitin‐proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic cultures

  2002cited by this paper
• The ubiquitin‐proteasome pathway and proteasome inhibitors

  2001cited by this paper
• α‐Synuclein metabolism and aggregation is linked to ubiquitin‐independent degradation by the proteasome

  2001cited by this paper
• Depletion of glial cell line-derived neurotrophic factor in substantia nigra neurons of Parkinson's disease brain.

  2001cited by this paper
• Involvement of c-Jun N-terminal kinase and caspase 3-like protease in DNA damage-induced, p53-mediated apoptosis of cultured mouse cerebellar granule neurons.

  2001cited by this paper
• Delayed infusion of GDNF promotes recovery of motor function in the partial lesion model of Parkinson's disease

  2001cited by this paper
• Neuronal life and death: an essential role for the p53 family

  2000cited by this paper
• Mitogen-activated protein kinase pathway mediates peroxynitrite-induced apoptosis in human dopaminergic neuroblastoma SH-SY5Y cells.

  1999cited by this paper
• The mitogen-activated protein (MAP) kinase cascade can either stimulate or inhibit DNA synthesis in primary cultures of rat hepatocytes depending upon whether its activation is acute/phasic or chronic.

  1998cited by this paper
• GDNF administration induces recovery of the nigrostriatal dopaminergic system both in young and aged parkinsonian mice

  1998influential reference
• Differences in nigral neuron number and sensitivity to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in C57/bl and CD-1 mice.

  1994cited by this paper
• The absolute number of nerve cells in substantia nigra in normal subjects and in patients with Parkinson's disease estimated with an unbiased stereological method.

  1991cited by this paper
• The FASEB Journal • Research Communication Prevention and restoration of lactacystin-induced

  year unknowncited by this paper

• GDNF reduces fibril-induced early-stage alpha-synuclein pathology after delivery of 20S proteasome inhibitor lactacystin.

  2025cites this paper
• Nicotinamide riboside first alleviates symptoms but later downregulates dopamine metabolism in proteasome inhibition mouse model of Parkinson's disease

  2024cites this paper
• Human Neural Progenitors Expressing GDNF Enhance Retinal Protection in a Rodent Model of Retinal Degeneration

  2023cites this paper
• Increased Physiological GDNF Levels Have No Effect on Dopamine Neuron Protection and Restoration in a Proteasome Inhibition Mouse Model of Parkinson’s Disease

  2023cites this paper
• PHYSICAL ACTIVITY–INDUCED NEUROPROTECTION IN PARKINSON’S DISEASE IS MEDIATED BY NEUROTROPHIC FACTORS

  2020cites this paper
• Glial Cell Line–Derived Neurotrophic Factor Receptor Rearranged During Transfection Agonist Supports Dopamine Neurons In Vitro and Enhances Dopamine Release In Vivo

  2019cites this paper
• Interneuronas estriatales productoras de GDNF: características moleculares y rol en la neuroprotección catecolaminérgica

  2019cites this paper
• Cell secretome based approaches in Parkinson’s disease regenerative medicine

  2018cites this paper
• Regulatable Lentiviral Hematopoietic Stem Cell Gene Therapy in a Mouse Model of Parkinson's Disease

  2018cites this paper
• A Central Role for Phosphorylated p38α in Linking Proteasome Inhibition-Induced Apoptosis and Autophagy

  2017cites this paper
• Intrastriatal Transplantation of Human Neural Stem Cells Restores the Impaired Subventricular Zone in Parkinsonian Mice

  2017cites this paper
• Role of Neurotrophic Factors in Parkinson's Disease.

  2017cites this paper
• Ret is essential to mediate GDNF's neuroprotective and neuroregenerative effect in a Parkinson disease mouse model

  2016cites this paper
• The Ubiquitin-Proteasome System: Potential Therapeutic Targets for Alzheimer’s Disease and Spinal Cord Injury

  2016cites this paper
• The Proteasome Inhibition Model of Parkinson’s Disease

  2016cites this paper
• Impact of the Secretome of Human Mesenchymal Stem Cells on Brain Structure and Animal Behavior in a Rat Model of Parkinson's Disease

  2016cites this paper
• A New VMAT‐2 Inhibitor NBI‐641449 in the Treatment of Huntington Disease

  2015cites this paper
• GDNF-based therapies, GDNF-producing interneurons, and trophic support of the dopaminergic nigrostriatal pathway. Implications for Parkinson’s disease

  2015cites this paper
• Histone deacetylase 6 regulates cytotoxic α-synuclein accumulation through induction of the heat shock response.

  2014cites this paper
• Cell based therapy in Parkinsonism

  2013cites this paper
• Nicotinamide N-methyltransferase expression in SH-SY5Y neuroblastoma and N27 mesencephalic neurones induces changes in cell morphology via ephrin-B2 and Akt signalling

  2013cites this paper
• The Potential Neuroprotection Mechanism of GDNF in the 6-OHDA-Induced Cellular Models of Parkinson’s Disease

  2013cites this paper
• Adeno-Associated Virus Type 2 Vector-Mediated Glial Cell Line-Derived Neurotrophic Factor Gene Transfer Induces Neuroprotection and Neuroregeneration in a Ubiquitin-Proteasome System Impairment Animal Model of Parkinson’s Disease

  2012cites this paper
• Systems Biology of Aging: Opportunities for Parkinson’s Disease

  2012cites this paper
• Nurr1 regulates Top IIβ and functions in axon genesis of mesencephalic dopaminergic neurons

  2012cites this paper
• Expressão de GDNF em células estriatais: efeito de fatores solúveis libertados por células do mesencéfalo ventral após lesão dopaminérgica

  2012cites this paper
• De la stimulation cérébrale profonde à l’étude physiopathologique de certaines formes génétiques de la Maladie de Parkinson

  2011cites this paper
• The TrkB-Positive Dopaminergic Neurons are Less Sensitive to MPTP Insult in the Substantia Nigra of Adult C57/BL Mice

  2011cites this paper
• Influence of lithium treatment on GDNF serum and CSF concentrations in patients with early Alzheimer's disease.

  2011cites this paper
• Neuroprotective effects of MAPK/ERK1/2 and calpain inhibitors on lactacystin-induced cell damage in primary cortical neurons.

  2011cites this paper
• Effects of intrastriatal GDNF on the response of dopamine neurons to 6-hydroxydopamine: time course of protection and neurorestoration.

  2011cites this paper
• Glial cell line-derived neurotrophic factor protects midbrain dopaminergic neurons against lipopolysaccharide neurotoxicity

  2010cites this paper
• Mesenchymal stem cell‐secreted superoxide dismutase promotes cerebellar neuronal survival

  2010influential citation
• Recent progress in neurodegenerative disorder research in China

  2010cites this paper
• Genetic iron chelation protects against proteasome inhibition-induced dopamine neuron degeneration.

  2010cites this paper
• Phosphoproteome study reveals Hsp27 as a novel signaling molecule involved in GDNF-induced neurite outgrowth.

  2009cites this paper
• Cell death pathways in Parkinson’s disease: proximal triggers, distal effectors, and final steps

  2009cites this paper
• An insight into the mechanistic role of p53-mediated autophagy induction in response to proteasomal inhibition-induced neurotoxicity

  2009cites this paper
• Disruption of the Ubiquitin Proteasome System following Axonal Stretch Injury Accelerates Progression to Secondary Axotomy

  2009cites this paper
• Identification of glial‐cell‐line‐derived neurotrophic factor‐regulated proteins of striatum in mouse model of Parkinson disease

  2009cites this paper
• Role of ventral tegmental area glial cell line-derived neurotrophic factor in incubation of cocaine craving.

  2009cites this paper
• Glial cell-line derived neurotrophic factor (GDNF) concentrations in cerebrospinal fluid and serum of patients with early Alzheimer's disease and normal controls.

  2009cites this paper
• Akt signal transduction dysfunction in Parkinson's disease.

  2009cites this paper
• Differential effects of the dopamine neurotoxin MPTP in animals with a partial deletion of the GDNF receptor, GFR alpha1, gene.

  2008cites this paper
• Ret is essential to mediate GDNF’s neuroprotective and Ret is essential to mediate GDNF’s neuroprotective and neuroregenerative effect in a Parkinson disease mouse model neuroregenerative effect in a Parkinson disease mouse model

  year unknowncites this paper