Immunization with recombinant paraflagellar rod protein induces protective immunity against Trypanosoma cruzi infection.

In the present study, we have produced recombinant paraflagellar rod proteins (PFR) and report their use for successful vaccination of mice against Trypanosoma cruzi. This protection is associated with a highly polarized type 1 cytokine production profile. Additionally, we have analyzed the gene sequence encoding PFR-2 to determine the degree of conservation among seven highly diverse strains of T. cruzi, and found it to be highly conserved. The results presented here indicate that the PFR antigens are highly conserved, and immunization with rPFR-1, PFR-2, or an equimolar mix of the PFR-1, -2, and -3 proteins provides protective immunity against Trypanosoma cruzi.

• Publication year

  2003

• Venue

  Vaccine

• Publication date

  2003-06-20

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0264-410X(03)00108-7PMID 12798650
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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