Pertussis toxin B-oligomer inhibits HIV infection and replication in hu-PBL-SCID mice.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  International Immunology

• Publication date

  2005-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/INTIMM/DXH226PMID 15746245
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Inhibition of intra‐ and extra‐cellular Tat function and HIV expression by pertussis toxin B‐oligomer

  2004cited by this paper
• Daily Low-Dose Subcutaneous Interleukin-2 Added To Single- or Dual-Nucleoside Therapy in HIV Infection Does Not Protect Against CD4+ T-Cell Decline or Improve Other Indices of Immune Function: Results of a Randomized Controlled Clinical Trial (ACTG 248)

  2004cited by this paper
• Induction of Protective Immune Responses against R5 Human Immunodeficiency Virus Type 1 (HIV-1) Infection in hu-PBL-SCID Mice by Intrasplenic Immunization with HIV-1-Pulsed Dendritic Cells: Possible Involvement of a Novel Factor of Human CD4+ T-Cell Origin

  2003cited by this paper
• Effects of interleukin-2 therapy combined with highly active antiretroviral therapy on immune restoration in HIV-1 infection: a randomized controlled trial

  2003cited by this paper
• Identification of T cell-signaling pathways that stimulate latent HIV in primary cells

  2003cited by this paper
• Anti-nerve growth factor Ab abrogates macrophage-mediated HIV-1 infection and depletion of CD4+ T lymphocytes in hu-SCID mice

  2003cited by this paper
• Molecular characterization, reactivation, and depletion of latent HIV.

  2003cited by this paper
• Potent Immune Response against HIV-1 and Protection from Virus Challenge in hu-PBL-SCID Mice Immunized with Inactivated Virus-pulsed Dendritic Cells Generated in the Presence of IFN-α

  2003cited by this paper
• Activation of the signal transducer and activator of transcription 1 signaling pathway in thymocytes from HIV‐1‐infected human thymus

  2003cited by this paper
• Cell‐surface bound pertussis toxin induces polyclonal T cell responses with high levels of interferon‐γ in the absence of interleukin‐12

  2003cited by this paper
• Native and genetically inactivated pertussis toxins induce human dendritic cell maturation and synergize with lipopolysaccharide in promoting T helper type 1 responses.

  2002cited by this paper
• B-oligomer of pertussis toxin inhibits HIV-1 LTR-driven transcription through suppression of NF-kappaB p65 subunit activity.

  2002cited by this paper
• Clinical indicators of immune restoration following highly active antiretroviral therapy.

  2002cited by this paper
• RNA-based anti-HIV-1 gene therapeutic constructs in SCID-hu mouse model.

  2002cited by this paper
• Vaginal transmission of cell-associated HIV-1 in the mouse is blocked by a topical, membrane-modifying agent.

  2002cited by this paper
• Stimulation of HIV gp120-Specific Cytolytic T Lymphocyte Responses in Vitro and in Vivo Using a Detoxified Pertussis Toxin Vector

  2001cited by this paper
• Reversal of the CD4+/CD8+T-Cell Ratio in Lymph Node Cells upon In Vitro Mitogenic Stimulation by Highly Purified, Water-Soluble S3-S4 Dimer of Pertussis Toxin

  2001cited by this paper
• Selective Regulation of Human Immunodeficiency Virus-Infected CD4+ Lymphocytes by a Synthetic Immunomodulator Leads to Potent Virus Suppression In Vitro and in hu-PBL-SCID Mice

  2001cited by this paper
• The Binding Subunit of Pertussis Toxin Inhibits HIV Replication in Human Macrophages and Virus Expression in Chronically Infected Promonocytic U1 Cells1

  2001cited by this paper
• Immunologic and virologic response after tetanus toxoid booster among HIV-1- and HIV-2-infected Senegalese individuals.

  2001cited by this paper
• The B-Oligomer of Pertussis Toxin Inhibits Human Immunodeficiency Virus Type 1 Replication at Multiple Stages

  2000cited by this paper
• Antiviral Activity of 2′-Deoxy-3′-Oxa-4′-Thiocytidine (BCH-10652) against Lamivudine-Resistant Human Immunodeficiency Virus Type 1 in SCID-hu Thy/Liv Mice

  2000influential reference
• Type I interferon is a powerful inhibitor of in vivo HIV-1 infection and preserves human CD4(+) T cells from virus-induced depletion in SCID mice transplanted with human cells.

  1999cited by this paper
• Human immunodeficiency virus-1 infection requires pertussis toxin sensitive G-protein-coupled signalling and mediates cAMP downregulation.

  1999cited by this paper
• The B-Oligomer of Pertussis Toxin Deactivates Cc Chemokine Receptor 5 and Blocks Entry of M-Tropic HIV-1 Strains

  1999cited by this paper
• human immunodeficiency virus陽性のアメーバ性大腸炎の1例

  1998cited by this paper
• Pertussis toxin potentiates Th1 and Th2 responses to co-injected antigen: adjuvant action is associated with enhanced regulatory cytokine production and expression of the co-stimulatory molecules B7-1, B7-2 and CD28.

  1998cited by this paper
• Rational design of vaccines

  1997cited by this paper
• The role of the S-1 and B-oligomer components of pertussis toxin in its adjuvant properties for Th1 and Th2 cells.

  1997cited by this paper
• Bordetella pertussis-specific Th1/Th2 cells generated following respiratory infection or immunization with an acellular vaccine: comparison of the T cell cytokine profiles in infants and mice.

  1997cited by this paper
• U937-SCID mouse xenografts: a new model for acute in vivo HIV-1 infection suitable to test antiviral strategies.

  1997cited by this paper
• The Lymphocytosis-Promoting Agent Pertussis Toxin Affects Virus Burden and Lymphocyte Distribution in the SIV-Infected Rhesus Macaque

  1997cited by this paper
• Immunomodulation of murine experimental autoimmune encephalomyelitis by pertussis toxin: the protective activity, but not the disease-enhancing activity, can be attributed to the nontoxic B-oligomer.

  1997cited by this paper
• Antiviral efficacy in vivo of the anti-human immunodeficiency virus bicyclam SDZ SID 791 (JM 3100), an inhibitor of infectious cell entry

  1996cited by this paper
• Pharmacology of pertussis toxin B-oligomer.

  1996cited by this paper
• T-cell dysfunctions in hu-PBL-SCID mice infected with human immunodeficiency virus (HIV) shortly after reconstitution: in vivo effects of HIV on highly activated human immune cells

  1996cited by this paper
• Use of standardized SCID-hu Thy/Liv mouse model for preclinical efficacy testing of anti-human immunodeficiency virus type 1 compounds

  1996influential reference
• THE SCID MOUSE REACTION TO HUMAN PERIPHERAL BLOOD MONONUCLEAR LEUKOCYTE ENGRAFTMENT: NEUTROPHIL RECRUITMENT INDUCED EXPRESSION OF A WIDE SPECTRUM OF MURINE CYTOKINES AND MOUSE LEUKOPOIESIS, INCLUDING THYMIC DIFFERENTIATION

  1995cited by this paper
• The human immune system in hu-PBL-SCID mice.

  1995cited by this paper
• Pertussis toxin inhibits induction of human immunodeficiency virus type 1 in infected monocytes.

  1994cited by this paper
• Pathogenicity mechanisms of Bordetella.

  1994cited by this paper
• Enhancing effects of pertussis toxin B oligomer on the immunogenicity of influenza vaccine administered intranasally.

  1994cited by this paper
• Site-specific alterations in the B oligomer that affect receptor- binding activities and mitogenicity of pertussis toxin

  1993cited by this paper
• Pertussis toxin and target eukaryotic cells: binding, entry, and activation

  1992cited by this paper
• Human immunodeficiency virus infection of human lymph nodes in the SCID-hu mouse.

  1991cited by this paper
• Effect of bacterial toxins on human B cell activation. II. Mitogenic activity of the B subunit of cholera toxin

  1991cited by this paper
• The SCID mouse mutant: definition, characterization, and potential uses.

  1991cited by this paper
• Effect of bacterial toxins on human B cell activation I. Mitogenic activity of pertussis toxin

  1990cited by this paper
• Metabolic, humoral, and cellular responses in adult volunteers immunized with the genetically inactivated pertussis toxin mutant PT- 9K/129G

  1990cited by this paper
• Suppression of HIV infection in AZT-treated SCID-hu mice.

  1990cited by this paper
• Pertussis toxin effects on T lymphocytes are mediated through CD3 and not by pertussis toxin catalyzed modification of a G protein.

  1989cited by this paper
• Bacterial toxins affect early events of T lymphocyte activation.

  1989cited by this paper
• The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function.

  1988cited by this paper
• Transfer of a functional human immune system to mice with severe combined immunodeficiency

  1988cited by this paper
• Human immunodeficiency virus and the law.

  1987cited by this paper
• Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS).

  1983cited by this paper
• Isolation of human T-cell leukemia virus in acquired immune deficiency syndrome (AIDS).

  1983cited by this paper
• Bacterial Toxins

  1903cited by this paper

• Human Beta-Defensin 2 and 3 Inhibit HIV-1 Replication in Macrophages

  2021cites this paper
• Immunomodulation as a Novel Strategy for Prevention and Treatment of Bordetella spp. Infections

  2019cites this paper
• Evaluating Human Immune Responses for Vaccine Development in a Novel Human Spleen Cell-Engrafted NOD-SCID-IL2rγNull Mouse Model

  2018cites this paper
• Chemoattractant-mediated leukocyte trafficking enables HIV dissemination from the genital mucosa.

  2017cites this paper
• Identification of an Astrovirus Commonly Infecting Laboratory Mice in the US and Japan

  2013cites this paper
• Transcriptional Control of HIV Replication by Multiple Modulators and Their Implication for a Novel Antiviral Therapy

  2012cites this paper
• Bacteria and their toxins tamed for immunotherapy.

  2012cites this paper
• Pertussis toxin and adenylate cyclase toxin: key virulence factors of Bordetella pertussis and cell biology tools.

  2010cites this paper
• Chemokine Receptor CXCR4 Initiate Cross-Desensitization of the Pertussis Toxin Signals through the TCR to

  2009cites this paper
• Frontiers in Clinical Immunology 2008

  2009cites this paper
• Pertussis Toxin Signals through the TCR to Initiate Cross-Desensitization of the Chemokine Receptor CXCR41

  2009cites this paper
• Bacterial protein toxins: current and potential clinical use.

  2008cites this paper
• Humanized mice in translational biomedical research

  2007cites this paper
• Immunopathogenesis of HIV Infection

  2007cites this paper
• Chemokine Receptors and HIV/AIDS

  2007cites this paper
• The biology of dendritic cells and HIV infection

  2007cites this paper
• The regulation of HIV‐1 transcription: Molecular targets for chemotherapeutic intervention

  2006cites this paper
• Pertussis Toxin B-Oligomer Suppresses IL-6 Induced HIV-1 and Chemokine Expression in Chronically Infected U1 Cells via Inhibition of Activator Protein 11

  2006cites this paper
• Activator Protein 1 Chronically Infected U 1 Cells via Inhibition inInduced HIV-1 and Chemokine Expression Pertussis Toxin B-Oligomer Suppresses IL-6

  2005cites this paper
• Pertussis toxin B-oligomer dissociates T cell activation and HIV replication in CD4 T cells released from infected lymphoid tissue

  2005cites this paper