Visuomotor adaptive improvement and aftereffects are impaired differentially following cerebellar lesions in SCA and PICA territory

The aim of the present study was to elucidate the contribution of the superior and posterior inferior cerebellum to adaptive improvement and aftereffects in a visuomotor adaptation task. Nine patients with ischemic lesions within the territory of the posterior inferior cerebellar artery (PICA), six patients with ischemic lesions within the territory of the superior cerebellar artery (SCA) and 17 age-matched controls participated. All subjects performed center-out reaching movements under 60° rotation of visual feedback. For the assessment of aftereffects, we tested retention of adaptation and de-adaptation under 0° visual rotation. From this data we also quantified five measures of motor performance. Cerebellar lesion-symptom mapping was performed using magnetic resonance imaging subtraction analysis. Adaptive improvement during 60° rotation was significantly degraded in PICA patients and even more in SCA patients. Subtraction analysis revealed that posterior (Crus I) as well as anterior cerebellar regions (lobule V) showed a common overlap related to deficits in adaptive improvement. However, for aftereffect measures as well as for motor performance variables only SCA patients, but not PICA patients showed significant differences to control subjects. Subtraction analysis showed that affection of lobules V and VI were more common in patients with impaired retention and de-adaptation, respectively. Data shows that areas both within the superior and posterior inferior cerebellum are involved in adaptive improvement. However, only the superior cerebellum including lobules V and VI appears to be important for aftereffects and therefore true adaptive ability.

• Publication year

  2009

• Venue

  Experimental Brain Research

• Publication date

  2009-11-03

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1007/s00221-009-2052-6PMID 19885654PMCID 2832877
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2008influential reference
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  2008influential reference
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  2008influential reference
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  2007influential reference
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  2006influential reference
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  2006cited by this paper
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  2006cited by this paper
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  2005influential reference
• Intact ability to learn internal models of arm dynamics in Huntington's disease but not cerebellar degeneration.

  2005influential reference
• Throwing while looking through prisms

  2005influential reference
• Applications of prism adaptation: a tutorial in theory and method.

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  2004influential reference
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  2004cited by this paper
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  2004influential reference
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  2000influential reference
• Three-dimensional MRI atlas of the human cerebellum in proportional stereotaxic space.

  1999cited by this paper
• Visuomotor adaptation during inactivation of the dentate nucleus.

  1999cited by this paper
• The cerebellar cognitive affective syndrome.

  1998cited by this paper
• Deficit in learning of a motor skill requiring strategy, but not of perceptuomotor recalibration, with aging.

  1998influential reference
• Neural correlates of motor memory consolidation.

  1997cited by this paper
• Adaptation motor learning of arm movements in patients with cerebellar disease.

  1996cited by this paper
• Throwing while looking through prisms. I. Focal olivocerebellar lesions impair adaptation.

  1996influential reference
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  1996influential reference
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  1983influential reference
• Visual-motor adaptation. Quantitative demonstration in patients with posterior fossa involvement.

  1979influential reference
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  year unknowninfluential reference

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  2020cites this paper
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  year unknowncites this paper