PCPH/ENTPD5 expression confers to prostate cancer cells resistance against cisplatin-induced apoptosis through protein kinase Calpha-mediated Bcl-2 stabilization.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Cancer Research

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/0008-5472.CAN-08-2922PMID 19117992PMCID PMC2614304
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Current Status and Future Prospects for Satraplatin, an Oral Platinum Analogue

  2008cited by this paper
• Peroxide Is a Key Mediator of Bcl-2 Down-Regulation and Apoptosis Induction by Cisplatin in Human Lung Cancer Cells

  2008cited by this paper
• Regulation of Bcl-2 family proteins by posttranslational modifications.

  2008cited by this paper
• Protein kinase Cε makes the life and death decision

  2007cited by this paper
• PCPH/ENTPD5 expression enhances the invasiveness of human prostate cancer cells by a protein kinase C delta-dependent mechanism.

  2007cited by this paper
• PKC inhibitor Go6976 induces mitosis and enhances doxorubicin-paclitaxel cytotoxicity in urinary bladder carcinoma cells.

  2007cited by this paper
• The Bcl-2 apoptotic switch in cancer development and therapy

  2007cited by this paper
• Protein kinase C and other diacylglycerol effectors in cancer

  2007cited by this paper
• Mechanism of inhibition of sequestration of protein kinase C alpha/betaII by ceramide. Roles of ceramide-activated protein phosphatases and phosphorylation/dephosphorylation of protein kinase C alpha/betaII on threonine 638/641.

  2007cited by this paper
• PKCdelta signaling: mechanisms of DNA damage response and apoptosis.

  2007cited by this paper
• Cancer Statistics, 2007

  2007cited by this paper
• Is there a role for platinum chemotherapy in the treatment of patients with hormone‐refractory prostate cancer?

  2007cited by this paper
• PCPH / ENTPD 5 Expression Enhances the Invasiveness of Human Prostate Cancer Cells by a Protein Kinase C D – Dependent Mechanism

  2007cited by this paper
• Mechanism of Inhibition of Sequestration of Protein Kinase C α/βII by Ceramide

  2007cited by this paper
• Protein kinase Cepsilon makes the life and death decision.

  2007cited by this paper
• Apoptosis evasion: The role of survival pathways in prostate cancer progression and therapeutic resistance

  2006cited by this paper
• A Spatiotemporally Coordinated Cascade of Protein Kinase C Activation Controls Isoform-Selective Translocation

  2006cited by this paper
• PCPH expression is an early event in the development of testicular germ cell tumors.

  2006cited by this paper
• Posttranslational modifications of Bcl2 family members--a potential therapeutic target for human malignancy.

  2006cited by this paper
• c‐Myc‐dependent etoposide‐induced apoptosis involves activation of Bax and caspases, and PKCdelta signaling

  2006cited by this paper
• Upregulation of Bcl-2 is associated with cisplatin-resistance via inhibition of Bax translocation in human bladder cancer cells.

  2006cited by this paper
• Roles of Tyrosine Phosphorylation and Cleavage of Protein Kinase Cδ in Its Protective Effect Against Tumor Necrosis Factor-related Apoptosis Inducing Ligand-induced Apoptosis*

  2005cited by this paper
• Enhancement of Cisplatin Sensitivity of Cisplatin-Resistant Human Cervical Carcinoma Cells by Bryostatin 1

  2005cited by this paper
• Molecular mechanisms of protein kinase C-induced apoptosis in prostate cancer cells.

  2005cited by this paper
• Phorbol Ester-induced Apoptosis of C4-2 Cells Requires Both a Unique and a Redundant Protein Kinase C Signaling Pathway*

  2005cited by this paper
• Synthesis of Anilino‐monoindolylmaleimides as Potent and Selective PKCβ Inhibitors.

  2005cited by this paper
• Protein kinase C and prostate carcinogenesis: targeting the cell cycle and apoptotic mechanisms.

  2004cited by this paper
• Deregulated expression of the PCPH proto-oncogene in human breast cancers.

  2004cited by this paper
• Synthesis of anilino-monoindolylmaleimides as potent and selective PKCbeta inhibitors.

  2004cited by this paper
• Regulation of cell apoptosis by protein kinase c δ

  2004cited by this paper
• PKC α mediates chemoresistance in acute lymphoblastic leukemia through effects on Bcl2 phosphorylation

  2004cited by this paper
• The PCPH oncoprotein antagonizes the proapoptotic role of the mammalian target of rapamycin in the response of normal fibroblasts to ionizing radiation.

  2003cited by this paper
• Ribozyme‐mediated inhibition of PKCα sensitizes androgen‐independent human prostate cancer cells to cisplatin‐induced apoptosis

  2003cited by this paper
• The Bcl2 family: regulators of the cellular life-or-death switch

  2002cited by this paper
• Partial depletion of intracellular ATP mediates the stress-survival function of the PCPH oncoprotein.

  2002cited by this paper
• Signal-induced site specific phosphorylation targets Bcl2 to the proteasome pathway.

  2002cited by this paper
• Deregulated expression of the PCPH proto‐oncogene in rat mammary tumors induced with 7,12‐dimethylbenz[a]anthracene

  2002cited by this paper
• Gradual deregulation and loss of PCPH expression in the progression of human laryngeal neoplasia

  2002cited by this paper
• Expression of the Protein Product of the PCPH Proto-oncogene in Human Tumor Cell Lines

  2001cited by this paper
• Involvement of protein kinase C-δ in DNA damage-induced apoptosis

  2001cited by this paper
• Bcl‐2 phosphorylation is required for inhibition of oxidative stress‐induced lysosomal leak and ensuing apoptosis

  2001cited by this paper
• Phosphorylation of Bcl2 and regulation of apoptosis

  2001influential reference
• Identity between the PCPH proto-oncogene and the CD39L4 (ENTPD5) ectonucleoside triphosphate diphosphohydrolase gene.

  2001cited by this paper
• Involvement of protein kinase C-delta in DNA damage-induced apoptosis.

  2001cited by this paper
• Protein kinase C isozymes and the regulation of diverse cell responses.

  2000cited by this paper
• The role of protein kinase C isoforms in cell proliferation and apoptosis.

  2000cited by this paper
• Both normal and transforming PCPH proteins have guanosine diphosphatase activity but only the oncoprotein cooperates with Ras in activating extracellular signal-regulated kinase ERK1.

  2000cited by this paper
• Posttranslational Modification of Bcl-2 Facilitates Its Proteasome-Dependent Degradation: Molecular Characterization of the Involved Signaling Pathway

  2000cited by this paper
• The product of the cph oncogene is a truncated, nucleotide-binding protein that enhances cellular survival to stress

  1999cited by this paper
• The involvement of protein kinase C isoenzymes alpha, epsilon and zeta in the sensitivity to antitumor treatment and apoptosis induction.

  1999cited by this paper
• Protein kinase C isoenzyme patterns characteristically modulated in early prostate cancer.

  1999cited by this paper
• Tissue-specific expression, evolutionary conservation and localization of the cph proto-oncogene on Syrian hamster chromosome X.

  1996cited by this paper
• Protein kinase C is regulated in vivo by three functionally distinct phosphorylations.

  1995cited by this paper
• cph, a novel oncogene which cooperates with H-ras in the transformation of NIH3T3 fibroblasts.

  1994cited by this paper
• Cancer statistics

  1989cited by this paper
• For Personal Use. Only Reproduce with Permission from the Lancet Publishing Group. Pathological and Molecular Aspects of Prostate Cancer Prostate Cancer Ii

  year unknowncited by this paper

• Integrated machine learning based on cuproptosis and RNA methylation regulators to explore the molecular model of prostate cancer and provide novel insights to immunotherapy

  2025cites this paper
• PTEN phosphatase inhibits metastasis by negatively regulating the Entpd5/IGF1R pathway through ATF6

  2023cites this paper
• Protein Kinase C (PKC) Isozymes as Diagnostic and Prognostic Biomarkers and Therapeutic Targets for Cancer

  2022cites this paper
• PKCα and PKCδ: Friends and Rivals

  2022cites this paper
• Knockdown of ENTPD5 inhibits tumor metastasis and growth via regulating the GRP78/p-eIF-2α/CHOP pathway in serous ovarian cancer

  2022cites this paper
• ENTPD5: identification of splicing variants and their impact on cancer survival

  2021cites this paper
• [ENTPD5 gene is highly expressed in epithelial ovarian cancer: analysis based on Oncomine database and bioinformatics].

  2021cites this paper
• Ectonucleotidases in Inflammation, Immunity, and Cancer

  2021cites this paper
• miRNA Expression Signatures of Therapy Response in Squamous Cell Carcinomas

  2020cites this paper
• The disruption of protein-protein interactions as a therapeutic strategy for prostate cancer.

  2020cites this paper
• The complexities of PKCα signaling in cancer.

  2020cites this paper
• The Role of Calcium Signaling in Regulation of Epithelial-Mesenchymal Transition

  2020cites this paper
• Transmembrane Channel-Like 5 (TMC5) promotes prostate cancer cell proliferation through cell cycle regulation.

  2019cites this paper
• Propofol Alleviates Apoptosis Induced by Chronic High Glucose Exposure via Regulation of HIF-1α in H9c2 Cells

  2019cites this paper
• Eya2 Is Overexpressed in Human Prostate Cancer and Regulates Docetaxel Sensitivity and Mitochondrial Membrane Potential through AKT/Bcl-2 Signaling

  2019cites this paper
• Modulation of ERQC and ERAD: A Broad-Spectrum Spanner in the Works of Cancer Cells?

  2019cites this paper
• N-stearoyl-l-Tyrosine inhibits the cell senescence and apoptosis induced by H2O2 in HEK293/Tau cells via the CB2 receptor.

  2017cites this paper
• Norcantharidin induces autophagy-related prostate cancer cell death through Beclin-1 upregulation by miR-129-5p suppression

  2016cites this paper
• The La protein counteracts cisplatin-induced cell death by stimulating protein synthesis of anti-apoptotic factor Bcl2

  2016cites this paper
• Tailoring Chemotherapy in Early-Stage Breast Cancer: Based on Tumor Biology or Tumor Burden?

  2016cites this paper
• VEGF-activated miR-144 regulates autophagic survival of prostate cancer cells against Cisplatin

  2016cites this paper
• ENTPD5 Induces Apoptosis in Lung Cancer Cells via Regulating Caspase 3 Expression

  2015cites this paper
• p22phox confers resistance to cisplatin, by blocking its entry into the nucleus

  2015cites this paper
• Title Cordyceps cicadae induces G 2 / M cell cycle arrest in MHCC 97 Hhuman hepatocellular carcinoma cells : a proteomic study

  2014cites this paper
• Cordyceps cicadae induces G2/M cell cycle arrest in MHCC97H human hepatocellular carcinoma cells: a proteomic study

  2014cites this paper
• NTPDase5/PCPH as a New Target in Highly Aggressive Tumors: A Systematic Review

  2014cites this paper
• Protein Kinase C (PKC) Isozymes and Cancer

  2014cites this paper
• The ENTPD5/mt-PCPH oncoprotein is a catalytically inactive member of the ectonucleoside triphosphate diphosphohydrolase family

  2013influential citation
• A noncanonical NF-κB pathway through the p50 subunit regulates Bcl-2 overexpression during an oxidative-conditioning hormesis response.

  2013cites this paper
• Cisplatin increases B‐cell‐lymphoma‐2 expression via activation of protein kinase C and Akt2 in endometrial cancer cells

  2012influential citation
• P2Y11 impairs cell proliferation by induction of cell cycle arrest and sensitizes endothelial cells to cisplatin‐induced cell death

  2011cites this paper
• The GDA1_CD39 superfamily: NTPDases with diverse functions

  2011cites this paper
• Effect of p53 Genotype on Gene Expression and DNA Adducts in ENU-Exposed Mice

  2011cites this paper
• Proteomic analysis of the transitional endoplasmic reticulum in hepatocellular carcinoma: an organelle perspective on cancer.

  2010cites this paper
• Kindlin-2 controls sensitivity of prostate cancer cells to cisplatin-induced cell death.

  2010cites this paper
• Prognostic impact of ALDH1 in breast cancer: a story of stem cells and tumor microenvironment

  2010cites this paper
• Cancer/Testis Antigen CAGE Exerts Negative Regulation on p53 Expression through HDAC2 and Confers Resistance to Anti-cancer Drugs*

  2010cites this paper
• Caveolin‐1 promotes resistance to chemotherapy‐induced apoptosis in Ewing's sarcoma cells by modulating PKCα phosphorylation

  2010cites this paper
• Protein kinase C is inhibited by bisphosphonates in prostate cancer PC-3 cells.

  2010cites this paper
• PKC and Prostate Cancer

  2010cites this paper
• Clinical overview on Lipoplatin™: a successful liposomal formulation of cisplatin

  2009cites this paper
• Identification of GAS1 as an Epirubicin Resistance-related Gene in Human Gastric Cancer Cells with a Partially Randomized Small Interfering RNA Library*

  2009cites this paper