Impact of Sox9 Dosage and Hes1-mediated Notch Signaling in Controlling the Plasticity of Adult Pancreatic Duct Cells in Mice

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  2018

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• Reduction of Ptf1a Gene Dosage Causes Pancreatic Hypoplasia and Diabetes in Mice

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• Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas

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• Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development.

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• The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors

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• The p48 DNA‐binding subunit of transcription factor PTF1 is a new exocrine pancreas‐specific basic helix‐loop‐helix protein.

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• SOX9 modulates cancer biomarker and cilia genes in pancreatic cancer.

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• Differentiation Potential of Mesenchymal Stem Cells into Pancreatic β-Cells.

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• [Fibroblast growth factors and their effects in pancreas organogenesis].

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• Peribiliary Glands as a Niche of Extrapancreatic Precursors Yielding Insulin‐Producing Cells in Experimental and Human Diabetes

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