Chrysin as an Anti-Cancer Agent Exerts Selective Toxicity by Directly Inhibiting Mitochondrial Complex II and V in CLL B-lymphocytes

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Cancer Investigation

• Publication date

  2017-02-17

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1080/07357907.2016.1276187PMID 28301251
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Selective Anticancer Activity of Acacetin Against Chronic Lymphocytic Leukemia Using Both In Vivo and In Vitro Methods: Key Role of Oxidative Stress and Cancerous Mitochondria

  2016cited by this paper
• Ellagic acid, a polyphenolic compound, selectively induces ROS-mediated apoptosis in cancerous B-lymphocytes of CLL patients by directly targeting mitochondria

  2015cited by this paper
• Dracocephalum: Novel Anticancer Plant Acting on Liver Cancer Cell Mitochondria

  2014cited by this paper
• Targeting cancer cell mitochondria as a therapeutic approach.

  2013cited by this paper
• Mitochondrial complex II, a novel target for anti-cancer agents.

  2013cited by this paper
• Type II Fp of human mitochondrial respiratory complex II and its role in adaptation to hypoxia and nutrition-deprived conditions.

  2013cited by this paper
• Mitochondrial Complex II Can Generate Reactive Oxygen Species at High Rates in Both the Forward and Reverse Reactions*

  2012cited by this paper
• Assessment of mitochondrial respiratory chain enzymatic activities on tissues and cultured cells

  2012cited by this paper
• Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations.

  2012cited by this paper
• Methylated chrysin reduced cell proliferation, but antagonized cytotoxicity of other anticancer drugs in acute lymphoblastic leukemia

  2012cited by this paper
• The causes of cancer revisited: "mitochondrial malignancy" and ROS-induced oncogenic transformation - why mitochondria are targets for cancer therapy.

  2010cited by this paper
• From pathogenesis to treatment of chronic lymphocytic leukaemia

  2010cited by this paper
• Mitochondrial Targeting of Vitamin E Succinate Enhances Its Pro-apoptotic and Anti-cancer Activity via Mitochondrial Complex II*

  2010cited by this paper
• Apoptotic Effects of Chrysin in Human Cancer Cell Lines

  2010influential reference
• Targeting mitochondria for cancer therapy

  2010cited by this paper
• Suppression of Tumor Growth In vivo by the Mitocan α-tocopheryl Succinate Requires Respiratory Complex II

  2009cited by this paper
• From single- to multi-target drugs in cancer therapy: when aspecificity becomes an advantage.

  2008cited by this paper
• Forodesine, an inhibitor of purine nucleoside phosphorylase, induces apoptosis in chronic lymphocytic leukemia cells.

  2006influential reference
• Mitochondrial defects in primary leukemia cells: Biological consequences and therapeutic implications

  2005cited by this paper
• Jasmonates: novel anticancer agents acting directly and selectively on human cancer cell mitochondria.

  2005cited by this paper
• Apoptosis pathways in cancer and cancer therapy

  2004cited by this paper
• Flavonoids Induce Apoptosis in Human Leukemia U937 Cells Through Caspase- and Caspase-Calpain-Dependent Pathways

  2004cited by this paper
• Chrysin-induced apoptosis is mediated through caspase activation and Akt inactivation in U937 leukemia cells.

  2004cited by this paper
• The tumor suppressor cybL, a component of the respiratory chain, mediates apoptosis induction.

  2003cited by this paper
• Flavonoids: Promising anticancer agents

  2003cited by this paper
• Mitochondrial defects in cancer

  2002cited by this paper
• Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-XL

  1997cited by this paper

• Chrysin Exhibits Selective Antiproliferative and Antimigratory Activities in a Wide Range of Human-derived Cervical Cancer Cell Lines.

  2025cites this paper
• Sinapic Acid Protects Mortality and Toxicity Induced by N-Ethyl-N-Nitrosourea, a Full Carcinogen Agent, in Mice

  2025cites this paper
• Investigating the therapeutic potential of nasal administration of mitochondria on blood-brain barrier integrity and vasogenic brain Edema in a rat ischemic stroke model.

  2025cites this paper
• Comprehensive overview of how to fade into succinate dehydrogenase dysregulation in cancer cells by naringenin-loaded chitosan nanoparticles

  2024cites this paper
• Baicalin attenuates neuronal damage associated with SDH activation and PDK2-PDH axis dysfunction in early reperfusion.

  2024cites this paper
• Single-Cell Transcriptomics Reveals Early Effects of Ionizing Radiation on Bone Marrow Mononuclear Cells in Mice

  2024cites this paper
• Mitochondria Embedded in Degalactosylated Xyloglucan Hydrogels to Improve Mitochondrial Transplantation

  2024cites this paper
• Investigating the Therapeutic Effects of Nimodipine on Vasogenic Cerebral Edema and Blood-Brain Barrier Impairment in an Ischemic Stroke Rat Model.

  2024cites this paper
• Succinate metabolism: a promising therapeutic target for inflammation, ischemia/reperfusion injury and cancer

  2023cites this paper
• An Overview: The Diversified Role of Mitochondria in Cancer Metabolism

  2023cites this paper
• Transient inhibition of mitochondrial function by chrysin and apigenin prolong longevity via mitohormesis in C. elegans.

  2023cites this paper
• Impairment of electron transport chain and induction of apoptosis by chrysin nanoparticles targeting succinate-ubiquinone oxidoreductase in pancreatic and lung cancer cells

  2023cites this paper
• Chrysin a promising anticancer agent: recent perspectives

  2023cites this paper
• Phytochemicals and bioactive compounds effective against acute myeloid leukemia: A systematic review

  2023cites this paper
• Principle active metabolites of Pinus morrisonicola Hayata synergistically inhibit cell proliferation and autophagy to elevate apoptosis in hepatocellular carcinoma cells

  2023cites this paper
• Chrysin attenuates estradiol-induced endometrial hyperplasia in rats via enhancing PPARα activity

  2022cites this paper
• Curcumin-Loaded Chitosan Nanoparticle Preparation and Its Protective Effect on Celecoxib-induced Toxicity in Rat isolated Cardiomyocytes and Mitochondria

  2022cites this paper
• Mitochondria: how eminent in ageing and neurodegenerative disorders?

  2022cites this paper
• The Anti-Leukemic Activity of Natural Compounds

  2021cites this paper
• [Mechanism of PI3K/AKT/mTOR signaling pathway for mediating anti-inflammatory and anti-oxidant effects of chrysin: a protein microarray-based study].

  2021cites this paper
• Potential therapeutic activities and novel delivery systems of chrysin-a nature’s boon

  2021cites this paper
• Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin

  2021cites this paper
• Celecoxib decreases mitochondrial complex IV activity and induces oxidative stress in isolated rat heart mitochondria: An analysis for its cardiotoxic adverse effect

  2020cites this paper
• Regulation of succinate dehydrogenase and role of succinate in cancer.

  2020cites this paper
• Pathogenic Mechanisms and Therapeutic Implication in Nickel-induced Cell Damage.

  2020cites this paper
• Contrasting Role of Dose Increase in Modulating Sofosbuvir-Induced Hepatocyte Toxicity

  2020cites this paper
• Curcumin attenuates bevacizumab-induced toxicity via suppressing oxidative stress and preventing mitochondrial dysfunction in heart mitochondria

  2020cites this paper
• Mesalazine Induces Oxidative Stress and Cytochrome c Release in Isolated Rat Heart Mitochondria: An Analysis of Cardiotoxic Effects

  2020cites this paper
• 1,25-Dihydroxyvitamin D3 Prevents Deleterious Effects of Erythromycin on Mitochondrial Function in Rat Heart Isolated Mitochondria.

  2020cites this paper
• Chrysin Induced Cell Apoptosis and Inhibited Invasion Through Regulation of TET1 Expression in Gastric Cancer Cells

  2020cites this paper
• Chrysin Induced Cell Apoptosis and Inhibited Invasion Through Regulation of TET1 Expression in Gastric Cancer Cells

  2020cites this paper
• Chrysin ameliorates aluminum phosphide‐induced oxidative stress and mitochondrial damages in rat cardiomyocytes and isolated mitochondria

  2020cites this paper
• Chrysin Inhibits High Glucose-Induced Migration on Chorioretinal Endothelial Cells via VEGF and VEGFR Down-Regulation

  2020cites this paper
• Stabilization of Mitochondrial Function by Ellagic Acid Prevents Celecoxib-induced Toxicity in Rat Cardiomyocytes and Isolated Mitochondria

  2020cites this paper
• Brain Bio-Energetic State Does Not Correlate to Muscle Mitochondrial Function in Huntington’s Disease

  2020cites this paper
• Therapeutic Applications of Honey and its Phytochemicals: Vol.1

  2020cites this paper
• Heath Benefits of Phenolic Compounds in Honey: An Essay

  2020cites this paper
• Molecular Mechanistic Approach of Important Antileukemic Compounds Present in Honey

  2020cites this paper
• OTT_A_246031 3277..3287

  2020cites this paper
• Mitochondrial transplantation as a potential and novel master key for treatment of various incurable diseases

  2019cites this paper
• Selective toxicity of chrysin on mitochondria isolated from livers of a HCC rat model.

  2019cites this paper
• Mechanistic approach of the inhibitory effect of chrysin on inflammatory and apoptotic events implicated in radiation-induced premature ovarian failure: Emphasis on TGF-β/MAPKs signaling pathway.

  2019cites this paper
• Contrasting Role of Concentration in Rivaroxaban Induced Toxicity and Oxidative Stress in Isolated Kidney Mitochondria

  2019cites this paper
• Current Advance of Therapeutic Agents in Clinical Trials Potentially Targeting Tumor Plasticity

  2019cites this paper
• Chrysin: Pharmacological and therapeutic properties.

  2019cites this paper
• Anticancer and Neuroprotective Activity of Chrysin: Recent Advancement

  2019cites this paper
• Chrysin ameliorates cerebral ischemia/reperfusion (I/R) injury in rats by regulating the PI3K/Akt/mTOR pathway.

  2019cites this paper
• Evaluation of Morphological and Mitochondrial Alterations of Mouse Fetus after Exposure to Methyl tert-butyl Ether

  2019cites this paper
• Mitochondria in Neuroprotection by Phytochemicals: Bioactive Polyphenols Modulate Mitochondrial Apoptosis System, Function and Structure

  2019cites this paper
• Analysis of apoptosis related genes in nurses exposed to anti-neoplastic drugs

  2019cites this paper
• Toxicity of Fe2O3 nanoparticles on human blood lymphocytes

  2019cites this paper
• Toxicity of nanotitanium dioxide (TiO2-NP) on human monocytes and their mitochondria

  2018cites this paper
• Role of Natural Compounds in Prevention and Treatment of Chronic Lymphocytic Leukemia

  2018cites this paper
• Leukemia therapy by flavonoids: Future and involved mechanisms

  2018influential citation
• Chrysin Attenuates Cell Viability of Human Colorectal Cancer Cells through Autophagy Induction Unlike 5-Fluorouracil/Oxaliplatin

  2018cites this paper
• Synthesis and toxicity assessment of 3-oxobutanamides against human lymphocytes and isolated mitochondria.

  2017cites this paper