Atypical protein kinase C induces cell transformation by disrupting Hippo/Yap signaling

aPKC is highly expressed and activated in cancers of epithelial origin. aPKC is sufficient to disrupt apical-basal polarity and overcome contact inhibition of epithelial cell growth to promote a transformed phenotype by deregulating Hippo/Yap signaling.

• Publication year

  2015

• Venue

  Molecular Biology of the Cell

• Publication date

  2015-10-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1091/mbc.E15-05-0265PMID 26269582PMCID 4603929
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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