SCIENCE@home

In vitro antiprotozoal activity of poly(rhodanine)-coated zinc oxide nanoparticles against Trichomonas gallinae

Mohammad Soleimani Lashkenari,A. Nikpay,M. Soltani,A. Gerayeli

Published 2020 in Journal of Dispersion Science and Technology

ABSTRACT

Abstract Recently utilization of nanoparticles in biological application has been increased due to their enhanced performance in drug delivery, anti-microbial and antiparasitic application. Researchers who work on developing new functional materials by antiparasitic properties are suffering from the lack of specific protocols for in-vitro investigation. In addition, investigation of nanoparticles performance by SEM & TEM could help us to assess their mechanism of action. Most of researchers have problem in preparing biological samples for SEM & TEM analysis. In the present study, pure ZnO nanoparticles and poly(rhodanine)-coated ZnO nanoparticles were truly synthesized and characterized. The antiparasitic activities of both nanoparticles were tested against Trichomonas gallinae parasite in vitro. The average sizes of uncoated and poly(rhodanine)-coated ZnO nanoparticles were 66.1 and 161.9 nm, respectively and a significant reduction for viability (p < 0.01) was observed for poly(rhodanine)-coated ZnO nanoparticles against Trichomonas gallinae. Moreover, the inhibitory concentration for 2 hours (IC50-2h) of pure ZnO nanoparticles and poly(rhodanine)-coated ZnO nanoparticles for this parasite was 2.5 and 10 mg/mL, respectively. Accordingly, these NPs could be suggested as a new nanoagent for safe and effective treatment of Trichomonas gallinae parasites. In addition SEM analysis was utilized to investigate the interaction of Trichomonas gallinae cell and poly(rhodanine)-coated ZnO nanoparticles. GRAPHICAL ABSTRACT

PUBLICATION RECORD

CITATION MAP

EXTRACTION MAP

CLAIMS

  • No claims are published for this paper.

CONCEPTS

  • No concepts are published for this paper.

REFERENCES

Showing 1-30 of 30 references · Page 1 of 1

CITED BY

Showing 1-7 of 7 citing papers · Page 1 of 1