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An Alternative to the Breeder’s and Lande’s Equations

B. Houchmandzadeh

Published 2013 in G3: Genes, Genomes, Genetics

ABSTRACT

The breeder’s equation is a cornerstone of quantitative genetics, widely used in evolutionary modeling. Noting the mean phenotype in parental, selected parents, and the progeny by E(Z0), E(ZW), and E(Z1), this equation relates response to selection R = E(Z1) − E(Z0) to the selection differential S = E(ZW) − E(Z0) through a simple proportionality relation R = h2S, where the heritability coefficient h2 is a simple function of genotype and environment factors variance. The validity of this relation relies strongly on the normal (Gaussian) distribution of the parent genotype, which is an unobservable quantity and cannot be ascertained. In contrast, we show here that if the fitness (or selection) function is Gaussian with mean μ, an alternative, exact linear equation of the form R′ = j2S′ can be derived, regardless of the parental genotype distribution. Here R′ = E(Z1) − μ and S′ = E(ZW) − μ stand for the mean phenotypic lag with respect to the mean of the fitness function in the offspring and selected populations. The proportionality coefficient j2 is a simple function of selection function and environment factors variance, but does not contain the genotype variance. To demonstrate this, we derive the exact functional relation between the mean phenotype in the selected and the offspring population and deduce all cases that lead to a linear relation between them. These results generalize naturally to the concept of G matrix and the multivariate Lande’s equation Δz¯=GP−1S. The linearity coefficient of the alternative equation are not changed by Gaussian selection.

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