TCR Scanning of Peptide/MHC through Complementary Matching of Receptor and Ligand Molecular Flexibility

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Journal of Immunology

• Publication date

  2014-03-15

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.4049/jimmunol.1302953PMID 24523505PMCID PMC3992338
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2009cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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