Coamplification of DAD-R, SOX5, and EKI1 in human testicular seminomas, with specific overexpression of DAD-R, correlates with reduced levels of apoptosis and earlier clinical manifestation.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Cancer Research

• Publication date

  2002-03-15

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 11912161
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Overexpression of a Mammalian Ethanolamine-specific Kinase Accelerates the CDP-ethanolamine Pathway*

  2001cited by this paper
• Molecular Cloning: A Laboratory Manual

  2001cited by this paper
• Overrepresentation of the short arm of chromosome 12 is related to invasive growth of human testicular seminomas and nonseminomas

  2000influential reference
• Inhibition of N-linked glycosylation causes apoptosis in hamster BHK21 cells.

  2000cited by this paper
• A novel human processed gene, DAD‐R, maps to 12p12 and is expressed in several organs

  2000cited by this paper
• Mice lacking Dad1, the defender against apoptotic death-1, express abnormal N-linked glycoproteins and undergo increased embryonic apoptosis.

  2000cited by this paper
• Restricted 12p amplification and RAS mutation in human germ cell tumors of the adult testis.

  2000influential reference
• Heterogeneity in alkaline phosphatase isozyme expression in human testicular germ cell tumours: An enzyme‐/immunohistochemical and molecular analysis

  1999cited by this paper
• Histological Typing of Testis Tumours, Edition, F.K. Mostofi, I.A. Sesterhenn, L.H. Sobin. Springer-Verlag, Berlin (1998), 3-540-63374-x, Pathologists in 9 countries 132 pages with 175 figures (coloured) DM 118.-; öS 862.-; sFr 107.50; GBP 45.50; US$ 74.00.

  1999cited by this paper
• Phosphorylation of ethanolamine, methylethanolamine, and dimethylethanolamine by overexpressed ethanolamine kinase in NIH 3T3 cells decreases the co-mitogenic effects of ethanolamines and promotes cell survival.

  1998cited by this paper
• Histological Typing of Testis Tumours

  1998cited by this paper
• Loss of imprinting of IGF2 and not H19 in breast cancer, adjacent normal tissue and derived fibroblast cultures

  1998cited by this paper
• Identification of the critical region of 12p over-representation in testicular germ cell tumors of adolescents and adults

  1998influential reference
• DAD1, the defender against apoptotic cell death, is a subunit of the mammalian oligosaccharyltransferase.

  1997cited by this paper
• X inactivation in human testicular tumors. XIST expression and androgen receptor methylation status.

  1997cited by this paper
• dad-1, A putative programmed cell death suppressor gene in rice.

  1997cited by this paper
• Dominant transformation by mutated human ras genes in vitro requires more than 100 times higher expression than is observed in cancers.

  1997cited by this paper
• The highly conserved DAD1 protein involved in apoptosis is required for N‐linked glycosylation

  1997cited by this paper
• Choline/ethanolamine kinase from mammalian tissues.

  1997cited by this paper
• Glycolipids of human primary testicular germ cell tumours.

  1996cited by this paper
• Fluorescence in situ hybridization-based approaches for detection of 12p overrepresentation, in particular i(12p), in cell lines of human testicular germ cell tumors of adults.

  1996influential reference
• Increase in testicular cancer incidence in six European countries: a birth cohort phenomenon.

  1996cited by this paper
• Apoptosis of human seminoma cells upon disruption of their microenvironment.

  1996cited by this paper
• Comparative analysis of cell surface antigens expressed by cell lines derived from human germ cell tumours

  1996cited by this paper
• Reviews of chromosome studies in urological tumors. III. Cytogenetics and genes in testicular tumors.

  1996cited by this paper
• Cloning and characterization of SOX5, a new member of the human SOX gene family.

  1996cited by this paper
• Aberrant platelet-derived growth factor alpha-receptor transcript as a diagnostic marker for early human germ cell tumors of the adult testis.

  1996cited by this paper
• Fiber FISH as a DNA Mapping Tool

  1996cited by this paper
• Expression of immunohistochemical markers for testicular carcinoma in situ by normal human fetal germ cells.

  1995cited by this paper
• p53 immunohistochemistry as an independent prognostic factor for superficial transitional cell carcinoma of the bladder.

  1995cited by this paper
• No recurrent structural abnormalities apart from i(12p) in primary germ cell tumors of the adult testis

  1995cited by this paper
• Amplification of chromosome subregion 12p11.2-p12.1 in a metastasis of an i(12p)-negative seminoma: relationship to tumor progression?

  1994cited by this paper
• Overrepresentation of chromosome 12p sequences and karyotypic evolution in i(12p)-negative testicular germ-cell tumors revealed by fluorescence in situ hybridization.

  1993cited by this paper
• Immunohistochemical markers of carcinoma in situ of the testis also expressed in normal infantile germ cells

  1993cited by this paper
• Ultrastructure of developing and malignant germ cells.

  1993cited by this paper
• Molecular cloning of a human cDNA encoding a novel protein, DAD1, whose defect causes apoptotic cell death in hamster BHK21 cells

  1993cited by this paper
• Molecular cytogenetic analysis of i(12p)‐negative human male germ cell tumors

  1993cited by this paper
• DNA Ploidy in Testicular Germ Cell Neoplasms Histogenetic and Clinical Implications

  1992cited by this paper
• Molecular cloning : a laboratory manual. Cold Spring Harbor, NY

  1989cited by this paper
• Identification of mutations leading to the Lesch-Nyhan syndrome by automated direct DNA sequencing of in vitro amplified cDNA.

  1989influential reference
• Ploidy of primary germ cell tumors of the testis. Pathogenetic and clinical relevance.

  1989cited by this paper
• Smoking: the need for further medical studies.

  1989cited by this paper
• Decreased testicular cancer risk in men born in wartime.

  1989cited by this paper
• Specific chromosome change, i(12p), in testicular tumours?

  1982cited by this paper

• Report From the International Society of Urological Pathology (ISUP) Consultation Conference on Molecular Pathology of Urogenital Cancers

  2020cites this paper
• Predicting Gonadal Germ Cell Cancer in People with Disorders of Sex Development; Insights from Developmental Biology

  2019cites this paper
• Clinicopathologic Features and Chromosome 12p Status of Pediatric Sacrococcygeal Teratomas: A Multi-institutional Analysis

  2018cites this paper
• Identification of Sox6 as a regulator of pancreatic cancer development

  2018cites this paper
• Germ Cell Tumors from a Developmental Perspective: Cells of Origin, Pathogenesis, and Molecular Biology (Emerging Patterns)

  2017cites this paper
• SOX5 promotes epithelial-mesenchymal transition in osteosarcoma via regulation of Snail.

  2017cites this paper
• Targeting Phospholipid Metabolism in Cancer

  2016cites this paper
• PSCA acts as a tumor suppressor by facilitating the nuclear translocation of RB1CC1 in esophageal squamous cell carcinoma.

  2016cites this paper
• SOX5 promotes epithelial–mesenchymal transition and cell invasion via regulation of Twist1 in hepatocellular carcinoma

  2015cites this paper
• Identification of the SOX5 gene as a novel IGH-involved translocation partner in BCL2-negative follicular lymphoma with t(12;14)(p12.2;q32)

  2015cites this paper
• The oncogenic BRD4-NUT chromatin regulator drives aberrant transcription within large topological domains

  2015cites this paper
• Circulating Tumor Cells in Patients with Testicular Germ Cell Tumors

  2014cites this paper
• Detection and characterization of circulating tumor cells in patients with testicular germ cell tumors and prostate cancer

  2014cites this paper
• Expression and function of a novel isoform of Sox5 in malignant B cells.

  2014cites this paper
• Histological groups of human postpubertal testicular germ cell tumours harbour different genetic alterations.

  2014cites this paper
• Sox5 induces epithelial to mesenchymal transition by transactivation of Twist1.

  2014cites this paper
• Towards Optimal Diagnosis of Type II Germ Cell Tumors

  2011cites this paper
• Coexisting metastatic choriocarcinoma and bladder adenocarcinoma of common germ cell origin.

  2011cites this paper
• Biology of germ cell tumors.

  2011cites this paper
• A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia

  2011cites this paper
• Isochromosome 12p and polysomy 12 in primary central nervous system germ cell tumors: frequency and association with clinicopathologic features.

  2010influential citation
• A functional RANKL polymorphism associated with younger age at onset of rheumatoid arthritis.

  2010cites this paper
• Tumors of the male genital organs

  2010cites this paper
• Pathogenesis of Testicular Germ Cell Tumors from a Developmental Point of View

  2010cites this paper
• DNA fingerprinting tags novel altered chromosomal regions and identifies the involvement of SOX5 in the progression of prostate cancer

  2009cites this paper
• Testicular Cancer – Explanatory Models for high Cisplatin Chemosensibility and new Therapeutic Options

  2009cites this paper
• Efeitos citotóxicos e toxicogenômicos dos antineoplásicos cisplatina e gencitabina em células de carcinoma de bexiga

  2009cites this paper
• Sox5 can suppress platelet-derived growth factor B-induced glioma development in Ink4a-deficient mice through induction of acute cellular senescence

  2009cites this paper
• Pediatric central nervous system germ cell tumors: a review.

  2008cites this paper
• Stem cell factor as a novel diagnostic marker for early malignant germ cells

  2008cites this paper
• Exploiting orthologue diversity for systematic detection of gain-of-function phenotypes

  2008cites this paper
• Testikuläre Keimzelltumoren – Erklärungsmodelle für die hohe Ansprechrate auf Cisplatin-basierte Chemotherapien und neue Therapieoptionen

  2008cites this paper
• National Academy of Clinical Biochemistry laboratory medicine practice guidelines for use of tumor markers in testicular, prostate, colorectal, breast, and ovarian cancers.

  2008cites this paper
• Germ Cell Tumors of the Gonads: A Selective Review Emphasizing Problems in Drug Resistance and Current Therapy Options

  2008cites this paper
• Further characterization of the first seminoma cell line TCam‐2

  2008influential citation
• Biology of testicular germ cell tumors

  2008cites this paper
• Stem Cell Marker OCT3/4 in Biology and Diagnostics of Germ Cell Tumors

  2007cites this paper
• Malignant germ cell tumours of childhood: new associations of genomic imbalance

  2007cites this paper
• Upregulation of the SOX5 by promoter swapping with the P2RY8 gene in primary splenic follicular lymphoma

  2007cites this paper
• Chromosomes and Expression in Human Testicular Germ‐Cell Tumors

  2007cites this paper
• JKT-1 is not a human seminoma cell line.

  2007cites this paper
• Transcription factor SOX‐5 enhances nasopharyngeal carcinoma progression by down‐regulating SPARC gene expression

  2007cites this paper
• Sonographically documented stable seminoma: a case report

  2007cites this paper
• A case of primary testicular germ cell tumor with rhabdomyosarcoma metastases as an example of applying the FISH method to diagnostic pathology

  2007cites this paper
• Intratubular germ cell neoplasia of unclassified type.

  2006cites this paper
• Molecular genetic analysis of central nervous system germ cell tumors with comparative genomic hybridization

  2006cites this paper
• Activation of Wnt/β-Catenin Signaling in Distinct Histologic Subtypes of Human Germ Cell Tumors

  2006cites this paper
• Genomic and expression profiling of human spermatocytic seminomas: primary spermatocyte as tumorigenic precursor and DMRT1 as candidate chromosome 9 gene.

  2006cites this paper
• Activation of Wnt/beta-catenin signaling in distinct histologic subtypes of human germ cell tumors.

  2006cites this paper
• Activating mutations and/or expression levels of tyrosine kinase receptors GRB7, RAS, and BRAF in testicular germ cell tumors.

  2005cites this paper
• Fusion of the SUMO/Sentrin-specific protease 1 gene SENP1 and the embryonic polarity-related mesoderm development gene MESDC2 in a patient with an infantile teratoma and a constitutional t(12;15)(q13;q25).

  2005cites this paper
• Testicular germ-cell tumours in a broader perspective

  2005cites this paper
• New insights into the pathology and molecular biology of human germ cell tumors

  2004influential citation
• Chromosomes, genes, and development of testicular germ cell tumors

  2004cites this paper
• Genome-wide array-based comparative genomic hybridization reveals multiple amplification targets and novel homozygous deletions in pancreatic carcinoma cell lines.

  2004cites this paper
• Germinal tumor invasion and the role of the testicular stroma.

  2004cites this paper
• Chromosomes, genes, and development of testicular germ cell tumors.

  2004cites this paper
• Pathology and genetics of tumours of the lung , pleura, thymus and heart

  2004cites this paper
• Epidemiologic analysis of 1,442 children and adolescents registered in the German germ cell tumor protocols

  2004cites this paper
• Gene expression profiling identifies a set of transcripts that are up-regulated inhuman testicular seminoma.

  2004cites this paper
• Sox genes and cancer

  2004cites this paper
• The emerging phenotype of the testicular carcinoma in situ germ cell

  2003cites this paper
• The testicular germ cell tumour genome

  2003cites this paper
• Role of gain of 12p in germ cell tumour development

  2003influential citation
• The emerging phenotype of the testicular carcinoma in situ germ cell.

  2003cites this paper
• Current views on the pathogenesis of testicular germ cell tumours and perspectives for future research: Highlights of the 5th Copenhagen Workshop on Carcinoma in situ and Cancer of the Testis

  2003cites this paper
• Testis conserving chemotherapy in germ cell cancer: its potential to increase understanding of the biology and treatment of carcinoma‐in‐situ

  2003cites this paper
• Morphology of testicular parenchyma adjacent to germ cell tumours. An interim report

  2003cites this paper
• Extragonadale Keimzelltumoren bei Kindern und Jugendlichen - Untersuchungen zu Histogenese, Genetik und Klinik

  2002cites this paper
• Symposium 23A: Tumours of the testis

  2002influential citation
• Pathobiology of testicular germ cell tumors: views and news.

  2002cites this paper