Tissue-Specific Incorporation of Azadirachtin in the Malpighian Tubules of Locus ta migratoria

The retention, tissue distribution, and localization of [22,23-3H2]dihydroazadirachtin A was investigated in the female locust, Locusta migratoria. A constant quantity of 0.4 to 0.5 μg of dihydroazadirachtin A per gram body weight is recovered in the unchanged form 5 days after injection of any of the physiologically effective doses in the range of 1.5 to 3.0 pg/g. Malpighian tubules account for 73.7% of the amount of dihydroazadirachtin A which is retained in the whole body. In the Malpighian tubules it is localized in the basal and inner regions. It is inferred from these results, that dihydroazadirachtin A acts in its unchanged form through a high-affinity binding to organ-specific membrane receptors.

• Publication year

  1988

• Venue

  Zeitschrift für Naturforschung C

• Publication date

  1988-12-01

• Fields of study

  Biology

• Identifiers
  DOI 10.1515/znc-1988-11-1217
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Comprehensive insect physiology, biochemistry, and pharmacology

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