Vildagliptin ameliorates oxidative stress and pancreatic beta cell destruction in type 1 diabetic rats.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Archives of Medical Research

• Publication date

  2013-04-01

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.1016/j.arcmed.2013.03.004PMID 23523961
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• [Incretin-based therapy in patients with type 1 diabetes mellitus].

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• A novel dipeptidyl peptidase IV inhibitor DA-1229 ameliorates streptozotocin-induced diabetes by increasing β-cell replication and neogenesis.

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  2009cited by this paper
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  2003cited by this paper
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  2002cited by this paper
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  2001cited by this paper
• β-Cell death during progression to diabetes

  2001cited by this paper
• b-Cell death during progression to diabetes

  2001cited by this paper
• Type 1 diabetes: new perspectives on disease pathogenesis and treatment.

  2001cited by this paper
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  2000cited by this paper
• Lipid peroxidation, antioxidants and cardiovascular disease: how should we move forward?

  2000cited by this paper
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  1999cited by this paper
• Free radicals: important cause of pathologies refer to ageing.

  1999cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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• Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo.

  1995cited by this paper
• Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV.

  1995cited by this paper
• Carbonyl assays for determination of oxidatively modified proteins.

  1994cited by this paper
• Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum.

  1993cited by this paper
• Beta-cell dysfunction induced by chronic hyperglycemia. Current ideas on mechanism of impaired glucose-induced insulin secretion.

  1992cited by this paper
• β-Cell Dysfunction Induced by Chronic Hyperglycemia: Current Ideas on Mechanism of Impaired Glucose-Induced Insulin Secretion

  1992cited by this paper
• Increased degradation of dermal collagen in diabetic rats.

  1991cited by this paper
• Hyperglycaemia as an inducer as well as a consequence of impaired islet cell function and insulin resistance: implications for the management of diabetes

  1985cited by this paper
• Catalase in vitro.

  1984cited by this paper
• Pentose phosphate shunt, pyridine nucleotides, glutathione, and insulin secretion of fetal islets.

  1983cited by this paper
• Superoxide radical inhibits catalase.

  1982cited by this paper
• Dosage effect of streptozotocin on rat tissue enzyme activities and glycogen concentration.

  1982cited by this paper
• Microsomal lipid peroxidation.

  1978cited by this paper
• Cellular mechanisms of oxygen toxicity.

  1968cited by this paper
• Archives of

  year unknowncited by this paper

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