Structure and tRNA Specificity of MibB, a Lantibiotic Dehydratase from Actinobacteria Involved in NAI-107 Biosynthesis.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Cell Chemical Biology

• Publication date

  2016-03-17

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.chembiol.2015.11.017PMID 26877024PMCID PMC4798866
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• PqqD Is a Novel Peptide Chaperone That Forms a Ternary Complex with the Radical S-Adenosylmethionine Protein PqqE in the Pyrroloquinoline Quinone Biosynthetic Pathway*

  2015cited by this paper
• Expanded Natural Product Diversity Revealed by Analysis of Lanthipeptide-Like Gene Clusters in Actinobacteria

  2015cited by this paper
• The PqqD homologous domain of the radical SAM enzyme ThnB is required for thioether bond formation during thurincin H maturation

  2015cited by this paper
• Structural analysis of leader peptide binding enables leader-free cyanobactin processing

  2015cited by this paper
• A Prevalent Peptide-Binding Domain Guides Ribosomal Natural Product Biosynthesis

  2015influential reference
• Engineering the heterologous expression of lanthipeptides in Escherichia coli by multigene assembly

  2015cited by this paper
• The enterococcal cytolysin synthetase has an unanticipated lipid kinase fold

  2015cited by this paper
• Family of class I lantibiotics from actinomycetes and improvement of their antibacterial activities.

  2015cited by this paper
• Structure and mechanism of the tRNA-dependent lantibiotic dehydratase NisB

  2014influential reference
• Dissecting reactions of nonlinear precursor peptide processing of the class III lanthipeptide curvopeptin.

  2014cited by this paper
• Mechanistic Studies on the Substrate-Tolerant Lanthipeptide Synthetase ProcM

  2014cited by this paper
• Draft Genome Sequence of the Microbispora sp. Strain ATCC-PTA-5024, Producing the Lantibiotic NAI-107

  2014influential reference
• The Lantibiotic NAI-107 Binds to Bactoprenol-bound Cell Wall Precursors and Impairs Membrane Functions*

  2014cited by this paper
• The determination of tRNALeu recognition nucleotides for Escherichia coli L/F transferase

  2014cited by this paper
• A Price To Pay for Relaxed Substrate Specificity: A Comparative Kinetic Analysis of the Class II Lanthipeptide Synthetases ProcM and HalM2

  2014cited by this paper
• Specificity determinants for the two tRNA substrates of the cyclodipeptide synthase AlbC from Streptomyces noursei

  2014cited by this paper
• Structural investigation of ribosomally synthesized natural products by hypothetical structure enumeration and evaluation using tandem MS

  2014cited by this paper
• Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.

  2013cited by this paper
• In vitro activity of the nisin dehydratase NisB

  2013influential reference
• Heterologous production of the lantibiotic Ala(0)actagardine in Escherichia coli.

  2012cited by this paper
• Selectivity, directionality, and promiscuity in peptide processing from a Bacillus sp. Al Hakam cyclodehydratase.

  2012cited by this paper
• Contribution of the Actinobacteria to the growing diversity of lantibiotics

  2012cited by this paper
• Discovery, biosynthesis, and engineering of lantipeptides.

  2012cited by this paper
• Lantibiotics from Geobacillus thermodenitrificans

  2012cited by this paper
• Evolution of lanthipeptide synthetases

  2012cited by this paper
• Dissection of the bridging pattern of bovicin HJ50, a lantibiotic containing a characteristic disulfide bridge.

  2011cited by this paper
• Biosynthesis of the antimicrobial peptide epilancin 15X

  2011cited by this paper
• Biosynthesis of the antimicrobial peptide epilancin 15X and its N-terminal lactate.

  2011cited by this paper
• Efficacy of the New Lantibiotic NAI-107 in Experimental Infections Induced by Multidrug-Resistant Gram-Positive Pathogens

  2011cited by this paper
• The bacterial N‐end rule pathway: expect the unexpected

  2010cited by this paper
• Production of Lantipeptides in Escherichia coli

  2010cited by this paper
• Microbisporicin gene cluster reveals unusual features of lantibiotic biosynthesis in actinomycetes

  2010influential reference
• In silico analysis highlights the frequency and diversity of type 1 lantibiotic gene clusters in genome sequenced bacteria

  2010cited by this paper
• Directionality and Coordination of Dehydration and Ring Formation during Biosynthesis of the Lantibiotic Nisin

  2009cited by this paper
• Determining the structure and mode of action of microbisporicin, a potent lantibiotic active against multiresistant pathogens.

  2008cited by this paper
• Mechanistic Dissection of the Enzyme Complexes Involved in Biosynthesis of Lacticin 3147 and Nisin

  2008cited by this paper
• Identification of Essential Catalytic Residues of the Cyclase NisC Involved in the Biosynthesis of Nisin*

  2007cited by this paper
• Nisin Biosynthesis in vitro

  2007cited by this paper
• Lantibiotic Engineering: Molecular Characterization and Exploitation of Lantibiotic-Synthesizing Enzymes for Peptide Engineering

  2007cited by this paper
• Structure-function relationships of the lanthionine cyclase SpaC involved in biosynthesis of the Bacillus subtilis peptide antibiotic subtilin.

  2007cited by this paper
• Lacticin 481 synthetase phosphorylates its substrate during lantibiotic production.

  2005cited by this paper
• Biosynthesis and mode of action of lantibiotics.

  2005cited by this paper
• Lacticin 481: In Vitro Reconstitution of Lantibiotic Synthetase Activity

  2004cited by this paper
• Molecular basis of double‐stranded RNA‐protein interactions: structure of a dsRNA‐binding domain complexed with dsRNA

  1998cited by this paper
• Discriminating among the discriminator bases of tRNAs.

  1997cited by this paper
• Biosynthesis of Lantibiotic Nisin

  1996cited by this paper
• Oxidative decarboxylation of peptides catalyzed by flavoprotein EpiD. Determination of substrate specificity using peptide libraries and neutral loss mass spectrometry

  1995cited by this paper
• The discriminator base influences tRNA structure at the end of the acceptor stem and possibly its interaction with proteins.

  1993cited by this paper
• Structure of E. coli glutaminyl-tRNA synthetase complexed with tRNA(Gln) and ATP at 2.8 A resolution.

  1989cited by this paper

• Aminoacyl-tRNA-dependent enzymes in natural product biosynthesis: structure-function insights

  2026cites this paper
• Enabling Access to Novel Bacterial Biosynthetic Potential From ONT Draft Genomic Data

  2025cites this paper
• Structural insights into the substrate binding mechanism of the class I dehydratase MadB

  2025cites this paper
• Structural analysis of GodF, an O-glutamylation enzyme involved in goadsporin biosynthesis.

  2025cites this paper
• Structure-based discovery and definition of RiPP recognition elements

  2025cites this paper
• Aminoacyl-tRNA Specificity of a Ligase Catalyzing Non-ribosomal Peptide Extension

  2025cites this paper
• Promiscuity of lanthipeptide enzymes: new challenges and applications

  2025cites this paper
• Embleporicin: A Novel Class I Lanthipeptide from the Actinobacteria Embleya sp. NF3

  2024cites this paper
• Nisin-relevant antimicrobial peptides: synthesis strategies and applications.

  2024cites this paper
• Enzymatic Formation of an Aminovinyl Cysteine Residue in Ribosomal Peptide Natural Products.

  2024cites this paper
• Activity of Gut-Derived Nisin-like Lantibiotics against Human Gut Pathogens and Commensals

  2024cites this paper
• Computational approach to identify novel genomic features conferring high fitness in Bacillus atrophaeus CNY01 and Bacillus velezensis AK-0 associated with plant growth promotion (PGP) in apple

  2024cites this paper
• Genome Mining of Myxopeptins Reveals a Class of Lanthipeptide-Derived Linear Dehydroamino Acid-Containing Peptides from Myxococcus sp. MCy9171.

  2023cites this paper
• Use of the mCherry fluorescent protein to optimize the expression of class I lanthipeptides in Escherichia coli

  2023cites this paper
• Discovery, biosynthesis, and characterization of a lanthipeptide from Bacillus subtilis EH11 with a unique lanthionine ring pattern

  2023cites this paper
• Improved production of class I lanthipeptides in Escherichia coli

  2023cites this paper
• Divergent Evolution of Lanthipeptide Stereochemistry

  2022cites this paper
• Macrocyclization and Backbone Modification in RiPP Biosynthesis.

  2022cites this paper
• syn-Elimination of glutamylated threonine in lanthipeptide biosynthesis

  2022cites this paper
• Heterologous production of new lanthipeptides hazakensins A and B using a cryptic gene cluster of the thermophilic bacterium Thermosporothrix hazakensis

  2022cites this paper
• A scalable platform to discover antimicrobials of ribosomal origin

  2022cites this paper
• Class V Lanthipeptide Cyclase Directs the Biosynthesis of a Stapled Peptide Natural Product.

  2022cites this paper
• Unexpected Methyllanthionine Stereochemistry in the Morphogenetic Lanthipeptide SapT

  2022cites this paper
• Therapeutic Application of Lantibiotics and Other Lanthipeptides: Old and New Findings

  2021cites this paper
• Visualization and Analysis of the Dynamic Assembly of a Heterologous Lantibiotic Biosynthesis Complex in Bacillus subtilis

  2021cites this paper
• Mining and Biosynthesis of Bioactive Lanthipeptides From Microorganisms

  2021cites this paper
• A biosynthetic pathway to aromatic amines that uses glycyl-tRNA as nitrogen donor

  2021cites this paper
• Isolation and Analysis of the Nisin Biosynthesis Complex NisBTC: further Insights into Their Cooperative Action

  2021cites this paper
• Site-Specific Nonenzymatic Peptide S/O-Glutamylation Reveals the Extent of Substrate Promiscuity in Glutamate Elimination Domains.

  2021cites this paper
• Peptide backbone modifications in lanthipeptides.

  2021cites this paper
• Mutations in Dynamic Structural Elements Alter the Kinetics and Fidelity of the Multifunctional Class II Lanthipeptide Synthetase, HalM2.

  2021cites this paper
• Diverse evolutionary origins of microbial [4 + 2]-cyclases in natural product biosynthesis.

  2021cites this paper
• Structural Analysis of Class I Lanthipeptides from Pedobacter lusitanus NL19 Reveals an Unusual Ring Pattern.

  2021cites this paper
• Subcellular Localization and Assembly Process of the Nisin Biosynthesis Machinery in Lactococcus lactis

  2020cites this paper
• Recent Progress in Lanthipeptide Biosynthesis, Discovery, and Engineering

  2020cites this paper
• Precursor peptide-targeted mining of more than one hundred thousand genomes expands the lanthipeptide natural product family

  2020cites this paper
• A Heterotrimeric Dehydrogenase Complex Functions with Two Distinct YcaO Proteins to Install the Five Azole Heterocycles in the Thirty Five-Membered Thiopeptide Antibiotics Sulfomycins.

  2020cites this paper
• Minimal lactazole scaffold for in vitro thiopeptide bioengineering

  2020cites this paper
• A Structural View on the Maturation of Lanthipeptides

  2020influential citation
• New developments in RiPP discovery, enzymology and engineering.

  2020cites this paper
• Flexizyme-aminoacylated shortened tRNAs demonstrate that only the aminoacylated acceptor arms of the two tRNA substrates are required for cyclodipeptide synthase activity

  2020cites this paper
• Exploring the conformational landscape of a lanthipeptide synthetase using native mass spectrometry

  2020cites this paper
• The role of protein-protein interactions in the biosynthesis of ribosomally synthesized and post-translationally modified peptides.

  2019cites this paper
• Characterization of glutamyl-tRNA–dependent dehydratases using nonreactive substrate mimics

  2019cites this paper
• Mechanistic Studies of the Kinase Domains of Class IV Lanthipeptide Synthetases.

  2019cites this paper
• Assessing the Flexibility of the Prochlorosin 2.8 Scaffold for Bioengineering Applications.

  2019cites this paper
• Recent Advances in the Discovery and Biosynthetic Study of Eukaryotic RiPP Natural Products

  2019cites this paper
• O-Methyltransferase-mediated Incorporation of a β-Amino Acid in Lanthipeptides.

  2019cites this paper
• Minimal lactazole scaffold for in vitro production of pseudo-natural thiopeptides

  2019cites this paper
• Structural Biology of RiPP Natural Products Biosynthesis

  2019cites this paper
• Non-ribosomal Peptide Extension by a Peptide Amino-acyl tRNA Ligase.

  2019cites this paper
• Heterologous Production of Microbial Ribosomally Synthesized and Post-translationally Modified Peptides

  2018influential citation
• Use of Lactococcus lactis as a production system for peptides and enzymes encoded by a Lantibiotic gene cluster from Bifidobacterium longum.

  2018cites this paper
• Investigation of Substrate Recognition and Biosynthesis in Class IV Lanthipeptide Systems.

  2018cites this paper
• Investigation of Amide Bond Formation during Dehydrophos Biosynthesis.

  2018cites this paper
• Characterization of Leader Peptide Binding During Catalysis by the Nisin Dehydratase NisB.

  2018cites this paper
• Structural insights into enzymatic [4+2] aza-cycloaddition in thiopeptide antibiotic biosynthesis

  2017influential citation
• Structural Insights into Thioether Bond Formation in the Biosynthesis of Sactipeptides.

  2017cites this paper
• Mechanistic Understanding of Lanthipeptide Biosynthetic Enzymes

  2017cites this paper
• Two Flavoenzymes Catalyze the Post-Translational Generation of 5-Chlorotryptophan and 2-Aminovinyl-Cysteine during NAI-107 Biosynthesis.

  2017cites this paper
• Biosynthesis and molecular engineering of templated natural products

  2017cites this paper
• Employing the promiscuity of lantibiotic biosynthetic machineries to produce novel antimicrobials

  2017cites this paper
• Stoichiometry and structure of a lantibiotic maturation complex

  2017cites this paper
• Dissection of goadsporin biosynthesis by in vitro reconstitution leading to designer analogues expressed in vivo

  2017cites this paper
• Chimeric Leader Peptides for the Generation of Non-Natural Hybrid RiPP Products

  2017cites this paper
• Aminoacyl-tRNA-Utilizing Enzymes in Natural Product Biosynthesis.

  2017cites this paper
• Structures of the peptide-modifying radical SAM enzyme SuiB elucidate the basis of substrate recognition

  2017cites this paper
• The B1 Protein Guides the Biosynthesis of a Lasso Peptide

  2016cites this paper
• Cameo appearances of aminoacyl-tRNA in natural product biosynthesis.

  2016cites this paper
• Posttranslational Peptide-Modification Enzymes in Action: Key Roles for Leaders and Glutamate.

  2016influential citation