Facing resistance of H.pylori infection

Helicobacter pylori is an important human pathogen and a gram-negative, spiral shaped and microaerophilic bacteria with persistence colonization in gastric mucosa, causes gastroduodenal inflammation and destruction, resulting in diseases such as duodenal ulcer disease, gastric ulcer disease. When H.pylori discovered by Warren and Marshall, effective therapy developed for this infection and resulted in remarkable change in management of PUD and dyspepsia. Nowadays, the increasing prevalence of drug resistance has complicated successful therapy, considering more attention for appropriate therapy. Ideally, therapy should be based on pretreatment drug susceptibility testing, and empiric use of eradication therapies should assume the presence of antimicrobial drug resistance and use increased doses for 14 days.

• Publication year

  2011

• Venue

  Gastroenterology and hepatology from bed to bench

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  DOI 10.22037/GHFBB.V4I1.129PMID 24834148PMCID 4017401
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2009cited by this paper
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• Effect of addition of vitamin C to clarithromycin-amoxicillin-omeprazol triple regimen on Helicobacter pylori eradication.

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  2009cited by this paper
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  2009cited by this paper
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  2008cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2005cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2003cited by this paper
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  2002cited by this paper
• The Stool Antigen Test for Detection of Helicobacter pylori after Eradication Therapy

  2002influential reference
• Two new treatment regimens for Helicobacter pylori eradication: a randomised study.

  2001cited by this paper
• A new highly effective short‐term therapy schedule for Helicobacter pylori eradication

  2000cited by this paper
• The HOMER Study: The Effect of Increasing the Dose of Metronidazole When Given with Omeprazole and Amoxicillin to Cure Helicobacter pylori Infection

  2000cited by this paper
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  1999cited by this paper
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  1999cited by this paper
• A new quadruple therapy for Helicobacter pylori: influence of resistant strains on treatment outcome

  1999cited by this paper
• Antibiotic resistance in Helicobacter pylori : Implications for therapy

  1998cited by this paper
• A new quadruple therapy for the eradication of Helicobacter pylori. Effect of pretreatment with omeprazole on the cure rate

  1998cited by this paper
• Does Helicobacter pylori eradication depend on the period of amoxicillin treatment? A retrospective study

  1998cited by this paper
• Antibiotic resistance in Helicobacter pylori: implications for therapy.

  1998cited by this paper
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  1998cited by this paper
• vaccine in The Netherlands . persons vaccinated with inactivated poliovirus Poliovirus-specific immunoglobulin A in

  1997influential reference
• The best therapy for Helicobacter pylori infection: should efficacy or side-effect profile determine our choice?

  1995cited by this paper
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  1991cited by this paper
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  1944cited by this paper
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  year unknowncited by this paper

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