Effects of vitamin E on the NF-kappaB pathway in rats treated with the peroxisome proliferator, ciprofibrate.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Toxicology and Applied Pharmacology

• Publication date

  2004-08-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.TAAP.2004.03.006PMID 15289085
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2001cited by this paper
• Effects of peroxisome proliferators on glutathione and glutathione-related enzymes in rats and hamsters.

  2001cited by this paper
• Central role of PPARalpha in the mechanism of action of hepatocarcinogenic peroxisome proliferators.

  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  1999cited by this paper
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• Control of apoptosis by Rel/NF-kappaB transcription factors.

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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
• Regulation of IkappaBbeta degradation. Similarities to and differences from IkappaBalpha.

  1997cited by this paper
• IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK.

  1997cited by this paper
• Evidence against peroxisome proliferation-induced hepatic oxidative damage.

  1997cited by this paper
• Activate NF-kappa B or die?

  1997cited by this paper
• A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB.

  1997cited by this paper
• Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway.

  1997cited by this paper
• IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK

  1997cited by this paper
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  1996cited by this paper
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  1996cited by this paper
• Transformation of epithelial cells stably transfected with H2O2-generating peroxisomal urate oxidase.

  1996cited by this paper
• Treatment of rats with the peroxisome proliferator ciprofibrate results in increased liver NF-kB activity

  1996cited by this paper
• Non-genotoxic hepatocarcinogens stimulate DNA synthesis and their withdrawal induces apoptosis, but in different hepatocyte populations.

  1995cited by this paper
• Mechanisms of hepatocarcinogenicity of peroxisome-proliferating drugs and chemicals.

  1995cited by this paper
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  1995cited by this paper
• Hydrogen peroxide metabolism during peroxisome proliferation by fenofibrate.

  1995cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1991cited by this paper
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  1991cited by this paper
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  1991cited by this paper
• Carcinogenicity of peroxisome proliferators: evaluation and mechanisms.

  1990cited by this paper
• Effect of the peroxisome proliferator ciprofibrate on hepatic DNA synthesis and hepatic composition following partial hepatectomy in rats.

  1990cited by this paper
• Hepatic peroxisome proliferation and oxidative stress.

  1990cited by this paper
• Long-term effects of peroxisome proliferators on the balance between hydrogen peroxide-generating and scavenging capacities in the liver of Fischer-344 rats.

  1990cited by this paper
• Nafenopin, a peroxisome proliferator, depletes hepatic vitamin E content and elevates plasma oxidised glutathione levels in rats.

  1989cited by this paper
• Biochemical mechanisms of induction of hepatic peroxisome proliferation.

  1989cited by this paper
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  1988cited by this paper
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  1987cited by this paper
• Peroxisome proliferation and hepatocarcinogenesis.

  1987cited by this paper
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  1987cited by this paper
• Determination of peroxisomal fatty acyl-CoA oxidase activity using a lauroyl-CoA-based fluorometric assay.

  1986cited by this paper
• Differential regulation of hepatic glutathione transferase and glutathione peroxidase activities in the rat.

  1985cited by this paper
• Controlled death (apoptosis) of normal and putative preneoplastic cells in rat liver following withdrawal of tumor promoters.

  1984cited by this paper
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  1983cited by this paper
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  1983cited by this paper
• Design and analysis of experiments in the animal and medical sciences

  1980cited by this paper
• Vitamin E.

  1975cited by this paper
• Spectrophotometric method for determination of tocopherol in red blood cells.

  1973cited by this paper
• Vitamin E.

  1940cited by this paper

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