Kinetic isotope effects significantly influence intracellular metabolite [superscript 13]C labeling patterns and flux determination

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Unknown venue

• Publication date

  2013-08-01

• Fields of study

  Biology, Chemistry

• Identifiers

  No identifiers available.

• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Rational design of 13C-labeling experiments for metabolic flux analysis in mammalian cells

  2012cited by this paper
• Expanding the concepts and tools of metabolic engineering to elucidate cancer metabolism

  2012cited by this paper
• Transcriptional regulation of respiration in yeast metabolizing differently repressive carbon substrates

  2010cited by this paper
• 13C metabolic flux analysis for larger scale cultivation using gas chromatography-combustion-isotope ratio mass spectrometry.

  2010cited by this paper
• Evaluation of 13C isotopic tracers for metabolic flux analysis in mammalian cells.

  2009cited by this paper
• Metabolic flux analysis in plants: coping with complexity.

  2009cited by this paper
• Metabolic flux analysis as a tool in metabolic engineering of plants.

  2008cited by this paper
• Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy

  2008cited by this paper
• Analysis of 13C labeling enrichment in microbial culture applying metabolic tracer experiments using gas chromatography-combustion-isotope ratio mass spectrometry.

  2008cited by this paper
• Elementary metabolite units (EMU): a novel framework for modeling isotopic distributions.

  2007cited by this paper
• Metabolic flux analysis in a nonstationary system: fed-batch fermentation of a high yielding strain of E. coli producing 1,3-propanediol.

  2007cited by this paper
• Accurate assessment of amino acid mass isotopomer distributions for metabolic flux analysis.

  2007cited by this paper
• Determination of confidence intervals of metabolic fluxes estimated from stable isotope measurements.

  2006cited by this paper
• Metabolic networks in motion: 13C-based flux analysis

  2006cited by this paper
• Large-scale 13C-flux analysis reveals mechanistic principles of metabolic network robustness to null mutations in yeast

  2005cited by this paper
• Large-scale in vivo flux analysis shows rigidity and suboptimal performance of Bacillus subtilis metabolism

  2005cited by this paper
• Metabolic-flux analysis of Saccharomyces cerevisiae CEN.PK113-7D based on mass isotopomer measurements of (13)C-labeled primary metabolites.

  2005cited by this paper
• Fundamentals and systematics of the non-statistical distributions of isotopes in natural compounds

  2004cited by this paper
• Metabolic flux profiling of Escherichia coli mutants in central carbon metabolism using GC-MS.

  2003cited by this paper
• It Is All about Metabolic Fluxes

  2003cited by this paper
• Analysis of flux estimates based on (13)C-labelling experiments.

  2002cited by this paper
• Genealogy Profiling through Strain Improvement by Using Metabolic Network Analysis: Metabolic Flux Genealogy of Several Generations of Lysine-Producing Corynebacteria

  2002cited by this paper
• Network Identification and Flux Quantification in the Central Metabolism of Saccharomyces cerevisiae under Different Conditions of Glucose Repression

  2001cited by this paper
• Possible pitfalls of flux calculations based on (13)C-labeling.

  2001cited by this paper
• Metabolic flux distributions in Corynebacterium glutamicum during growth and lysine overproduction

  2000cited by this paper
• GC‐MS Analysis of Amino Acids Rapidly Provides Rich Information for Isotopomer Balancing

  2000cited by this paper
• Quantification of intracellular metabolic fluxes from fractional enrichment and 13C-13C coupling constraints on the isotopomer distribution in labeled biomass components.

  1999cited by this paper
• Bidirectional reaction steps in metabolic networks: IV. Optimal design of isotopomer labeling experiments.

  1999cited by this paper
• Quantitative analysis of metabolic fluxes in Escherichia coli, using two-dimensional NMR spectroscopy and complete isotopomer models.

  1999cited by this paper
• Bidirectional reaction steps in metabolic networks: III. Explicit solution and analysis of isotopomer labeling systems.

  1999cited by this paper
• Mass spectrometry for metabolic flux analysis.

  1999cited by this paper
• Isotopomer analysis using GC-MS.

  1999influential reference
• Multiple isotope effects as a probe of proton and hydride transfer in the 6-phosphogluconate dehydrogenase reaction.

  1998cited by this paper
• Oxidative decarboxylation of 6-phosphogluconate by 6-phosphogluconate dehydrogenase proceeds by a stepwise mechanism with NADP and APADP as oxidants.

  1998cited by this paper
• Metabolic fluxes in riboflavin-producing Bacillus subtilis

  1997cited by this paper
• Carbon Isotope Effects on the Fructose-1,6-bisphosphate Aldolase Reaction, Origin for Non-statistical 13C Distributions in Carbohydrates*

  1997influential reference
• Bidirectional reaction steps in metabolic networks: I. Modeling and simulation of carbon isotope labeling experiments.

  1997cited by this paper
• Bidirectional reaction steps in metabolic networks: II. Flux estimation and statistical analysis.

  1997cited by this paper
• Determination of the fluxes in the central metabolism of Corynebacterium glutamicum by nuclear magnetic resonance spectroscopy combined with metabolite balancing

  1996cited by this paper
• Biosynthetically directed fractional 13C-labeling of proteinogenic amino acids. An efficient analytical tool to investigate intermediary metabolism.

  1995cited by this paper
• Isotope effect studies of the chemical mechanism of pig heart NADP isocitrate dehydrogenase.

  1988cited by this paper
• Carbon isotope effects on the pyruvate dehydrogenase reaction and their importance for relative carbon-13 depletion in lipids.

  1987influential reference
• Use of multiple isotope effects to study the mechanism of 6-phosphogluconate dehydrogenase.

  1984cited by this paper
• Carbon isotopic fractionation in the biosynthesis of bacterial fatty acids. Ozonolysis of unsaturated fatty acids as a means of determining the intramolecular distribution of carbon isotopes

  1982influential reference
• Use of multiple isotope effects to determine enzyme mechanisms and intrinsic isotope effects. Malic enzyme and glucose-6-phosphate dehydrogenase.

  1982cited by this paper
• Mechanism of carbon isotope fractionation associated with lipid synthesis.

  1977cited by this paper
• Enzymatic fractionation of carbon isotopes by phosphoenolpyruvate carboxylase from c(4) plants.

  1973cited by this paper
• Carbon isotope discrimination in a plant possessing the C4 dicarboxylic acid pathway.

  1970cited by this paper
• Metabolic fractionation of C13 & C12 in plants

  1961cited by this paper
• Carbon isotope fractionation in formation of amino acids by photosynthetic organisms.

  1961cited by this paper

• Assessment of stable carbon isotope ^13С/^12С ratio in phthalates from surface waters using HPLC-HRMS-TOF approach

  2023cites this paper
• Increased methylglyoxal formation in plasma and tissues during a glucose tolerance test is derived from exogenous glucose

  2023cites this paper
• Quantifying Isotopologue Reaction Networks (QIRN): A modelling tool for predicting stable isotope fractionations in complex networks

  2022cites this paper
• Bacteria–photocatalyst sheet for sustainable carbon dioxide utilization

  2022cites this paper
• Towards model-driven characterization and manipulation of plant lipid metabolism.

  2020cites this paper
• Postprandial Metabolic Effects of Fiber Mixes Revealed by in vivo Stable Isotope Labeling in Humans

  2019cites this paper
• The rate of lactate production from glucose in hearts is not altered by per-deuteration of glucose.

  2017cites this paper
• Learning from quantitative data to understand central carbon metabolism.

  2017cites this paper
• 13C Metabolic Flux Analysis of acetate conversion to lipids by Yarrowia lipolytica.

  2016cites this paper
• Tracking the metabolic pulse of plant lipid production with isotopic labeling and flux analyses: Past, present and future.

  2015cites this paper
• Impact of kinetic isotope effects in isotopic studies of metabolic systems

  2015influential citation
• ¹³C-metabolic flux analysis of recombinant yeasts for biofuels applications

  2015cites this paper
• Metabolomic and 13C‐metabolic flux analysis of a xylose‐consuming Saccharomyces cerevisiae strain expressing xylose isomerase

  2015cites this paper
• Flux and reflux: metabolite reflux in plant suspension cells and its implications for isotope-assisted metabolic flux analysis.

  2014cites this paper
• Pulsed stable isotope-resolved metabolomic studies of cancer cells.

  2014cites this paper
• OpenFLUX2: 13C-MFA modeling software package adjusted for the comprehensive analysis of single and parallel labeling experiments

  2014cites this paper
• Automated Quantification of 13C Labeled Peptides

  2013cites this paper
• Experimental evidence and isotopomer analysis of mixotrophic glucose metabolism in the marine diatom Phaeodactylum tricornutum

  2013cites this paper
• Editorial: Metabolic modeling in biotechnology and medical research

  2013cites this paper
• Isotopic ratio outlier analysis global metabolomics of Caenorhabditis elegans.

  2013cites this paper