Distinct and regulated activities of human Gli proteins in Drosophila.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Current Biology

• Publication date

  1999-11-18

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0960-9822(00)80054-8PMID 10574767
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Gli proteins and Hedgehog signaling: development and cancer.

  1999cited by this paper
• Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus.

  1999influential reference
• Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression.

  1999cited by this paper
• Gli genes and limb development

  1999influential reference
• Cloning of Novel Isoforms of the Human Gli2 Oncogene and Their Activities To Enhance Tax-Dependent Transcription of the Human T-Cell Leukemia Virus Type 1 Genome

  1998cited by this paper
• Expression profile of Gli family members and Shh in normal and mutant mouse limb development

  1998cited by this paper
• Transducing Hedgehog: the story so far

  1998cited by this paper
• Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator

  1998cited by this paper
• The world according to bedgebog

  1997cited by this paper
• Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor.

  1997cited by this paper
• The world according to hedgehog.

  1997cited by this paper
• Molecular Models for Vertebrate Review Limb Development

  1997cited by this paper
• Expression of the mouse Gli and Ptc genes is adjacent to embryonic sources of hedgehog signals suggesting a conservation of pathways between flies and mice.

  1997cited by this paper
• Gli1 is a target of Sonic hedgehog that induces ventral neural tube development.

  1997cited by this paper
• The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal.

  1996cited by this paper
• Dual roles for patched in sequestering and transducing Hedgehog.

  1996cited by this paper
• Direct and long-range action of a DPP morphogen gradient.

  1996influential reference
• Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development.

  1996cited by this paper
• smoothened encodes a receptor-like serpentine protein required for hedgehog signalling

  1996cited by this paper
• Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins.

  1996cited by this paper
• Protein kinase A and hedgehog signaling in Drosophila limb development.

  1995cited by this paper
• Mutations that alter the timing and pattern of cubitus interruptus gene expression in Drosophila melanogaster.

  1995cited by this paper
• Compartment boundaries and the control of Drosopfiffa limb pattern by hedgehog protein

  1994cited by this paper
• Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs.

  1994cited by this paper
• Targeted gene expression as a means of altering cell fates and generating dominant phenotypes.

  1993cited by this paper
• Analysis of genetic mosaics in developing and adult Drosophila tissues.

  1993cited by this paper
• Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog.

  1992cited by this paper

• Amphioxus Gli knockout disrupts the development of left–right asymmetry but has limited impact on neural patterning

  2023cites this paper
• Reduced Smoothened level rescues Aβ-induced memory deficits and neuronal inflammation in animal models of Alzheimer's disease.

  2018cites this paper
• Influenza NS1 directly modulates Hedgehog signaling during infection

  2017cites this paper
• The Signal Transduction Network

  2016cites this paper
• Large-scale Computational Screening and Machine Learning Approaches to Drug Discovery

  2016cites this paper
• Epigenetic Pathways and Glioblastoma Treatment: Insights From Signaling Cascades

  2015cites this paper
• Gene and protein interactions in limb development : the case of Msx and Gli3

  2015cites this paper
• The CK1 Family: Contribution to Cellular Stress Response and Its Role in Carcinogenesis

  2014cites this paper
• The contrasting roles of primary cilia and cytonemes in Hh signaling.

  2014cites this paper
• Regulation of neural differentiation in mouse embryonic stem cells using small molecules

  2013cites this paper
• The Hedgehog Signal Transduction Network

  2012cites this paper
• The hedgehog knows many tricks.

  2011cites this paper
• Regulation of mammalian Gli proteins by Costal 2 and PKA in Drosophila reveals Hedgehog pathway conservation

  2011influential citation
• Deriving excitatory neurons of the neocortex from pluripotent stem cells.

  2011cites this paper
• A Novel Gli3 Enhancer Controls the Gli3 Spatiotemporal Expression Pattern through a TALE Homeodomain Protein Binding Site

  2011cites this paper
• Birth defects caused by mutations in human GLI3 and mouse Gli3 genes

  2010cites this paper
• Visualization of Gli Activity in Craniofacial Tissues of Hedgehog-Pathway Reporter Transgenic Zebrafish

  2010cites this paper
• Coordinated Translocation of Mammalian Gli Proteins and Suppressor of Fused to the Primary Cilium

  2010cites this paper
• The role of Parafibromin/Hyrax as a nuclear Gli/Ci-interacting protein in Hedgehog target gene control.

  2009cites this paper
• Expression of the glioma-associated oncogene homolog (GLI) 1 in human breast cancer is associated with unfavourable overall survival

  2009cites this paper
• Analysis of early ventral telencephalic defects in mice lacking functional Gli3 protein

  2009cites this paper
• Combined activity of the two Gli2 genes of zebrafish play a major role in Hedgehog signaling during zebrafish neurodevelopment.

  2008cites this paper
• Extended exposure to Sonic hedgehog is required for patterning the posterior digits of the vertebrate limb.

  2007cites this paper
• An Amphioxus Gli Gene Reveals Conservation of Midline Patterning and the Evolution of Hedgehog Signalling Diversity in Chordates

  2007cites this paper
• Segregating and patterning mesoderm from endoderm during development: Emerging roles for Hedgehog and FoxA

  2007cites this paper
• Hedgehog signaling in skeletal development.

  2006cites this paper
• Abnormal Positioning of Diencephalic Cell Types in Neocortical Tissue in the Dorsal Telencephalon of Mice Lacking Functional Gli3

  2006cites this paper
• The Contributions of Protein Kinase A and Smoothened Phosphorylation to Hedgehog Signal Transduction in Drosophila melanogaster

  2006cites this paper
• Genomics and expression profiles of the Hedgehog and Notch signaling pathways in sea urchin development.

  2006cites this paper
• Regulation of the Drosophila transcription factor, Cubitus interruptus, by two conserved domains.

  2006cites this paper
• CKI, there's more than one: casein kinase I family members in Wnt and Hedgehog signaling.

  2006cites this paper
• Dual degradation signals control Gli protein stability and tumor formation.

  2006cites this paper
• Overlapping and distinct transcriptional regulator properties of the GLI1 and GLI2 oncogenes.

  2006cites this paper
• Role of Hedgehog and Gli Signalling in Telencephalic Development

  2006cites this paper
• AbnormalPositioningofDiencephalicCellTypesin NeocorticalTissueintheDorsalTelencephalonofMice LackingFunctionalGli3

  2006cites this paper
• Hedgehog-gli signaling in human disease

  2006cites this paper
• Molekulargenetische Analyse der Gene GLI1, GLI2, GLI3, BTRC und IGF2 in Medulloblastomen und Basalzellkarzinomen

  2006cites this paper
• Cooperative requirement of the Gli proteins in neurogenesis

  2005cites this paper
• Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation

  2005cites this paper
• Expression of the human FUSED protein in Drosophila

  2005cites this paper
• Etude de la voie de signalisation Sonic Hedgehog et du contrôle de la prolifération cellulaire dans le cerveau mature de rongeurs

  2005cites this paper
• Dysregulation of hedgehog signalling predisposes to synovial chondromatosis

  2005cites this paper
• Shh signalling and the specification of neuronal identity.

  2004cites this paper
• The zebrafish iguana locus encodes Dzip1, a novel zinc-finger protein required for proper regulation of Hedgehog signaling

  2004cites this paper
• The role of transcriptional repression in Shh signalling and patterning of the ventral neural tube

  2004cites this paper
• The amino-terminal region of Gli3 antagonizes the Shh response and acts in dorsoventral fate specification in the developing spinal cord.

  2003cites this paper
• Loss of protein kinase Calpha expression may enhance the tumorigenic potential of Gli1 in basal cell carcinoma.

  2003influential citation
• Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate development

  2003influential citation
• Genetische Analyse von Conductin durch zielgerichtete Mutagenese in der Maus

  2003cites this paper
• Patched, hedgehog, and skin cancer.

  2003cites this paper
• Differential activities of Sonic hedgehog mediated by Gli transcription factors define distinct neuronal subtypes in the dorsal thalamus.

  2003cites this paper
• Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification.

  2003cites this paper
• Gli and hedgehog in cancer: tumours, embryos and stem cells

  2002cites this paper
• Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1.

  2002cites this paper
• Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity.

  2002cites this paper
• Gli1 can rescue the in vivo function of Gli2.

  2001cites this paper
• Hedgehog signaling in animal development: paradigms and principles.

  2001cites this paper
• Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation.

  2000cites this paper
• Expression of the vertebrate Gli proteins in Drosophila reveals a distribution of activator and repressor activities.

  2000cites this paper
• Cubitus interruptus-independent transduction of the Hedgehog signal in Drosophila.

  2000cites this paper
• Mouse Gli 1 mutants are viable but have defects in SHH signaling in combination with a Gli 2 mutation

  2000cites this paper
• Achieving neuronal patterning by repression

  2000cites this paper
• The zebrafish slow-muscle-omitted gene product is required for Hedgehog signal transduction and the development of slow muscle identity.

  2000cites this paper
• Hedgehog signalling in cancer

  2000cites this paper
• The sonic hedgehog-patched-gli pathway in human development and disease.

  2000cites this paper
• Gli 1 can rescue the in vivo function of Gli 2

  year unknowninfluential citation