Genetic analysis of HLA, NA and HPA typing in type 2 diabetes and ASO

We examined the genetic status of human leucocyte antigens (HLA), human platelet alloantigens (HPA) and neutrophil‐specific antigens (NA) in patients with type 2 diabetes mellitus and diabetic arteriosclerosis obliterans (ASO). To our knowledge, the present study is the first report showing the relationship among three genetic factors in type 2 diabetes mellitus and ASO patients. HLA typing was performed by the polymerase chain reaction (PCR)–restriction fragment length polymorphism method. HPA‐typing and NA‐typing were by a PCR‐sequence‐specific primer method. The incidence of HLA‐DRB1*1501 was found to be significant in type 2 diabetes and non‐diabetic, particularly ASO‐positive patients, compared to control subjects. There were no differences in NA1/NA2 between the control and diabetic or non‐diabetic ASO groups. However, the frequency of NA2/NA2 in ASO‐positive diabetes and non‐diabetic ASO patients was significantly higher than controls. The a/b genotype of HPA‐5a/5b was significantly lower in type 2 diabetes and non‐diabetic ASO‐positive patients than in controls. These findings suggest that genetic studies of HLA, NA and HPA could be useful to understand the pathogenesis of type 2 diabetes and ASO.

• Publication year

  2006

• Venue

  International Journal of Immunogenetics

• Publication date

  2006-04-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1111/j.1744-313X.2006.00581.xPMID 16611256PMCID 1464425
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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