MAPK p38 and JNK have opposing activities on TRAIL-induced apoptosis activation in NSCLC H460 cells that involves RIP1 and caspase-8 and is mediated by Mcl-1

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Apoptosis

• Publication date

  2013-03-02

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1007/s10495-013-0829-3PMID 23456625
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Kinome profiling of non-canonical TRAIL signaling reveals RIP1–Src–STAT3-dependent invasion in resistant non-small cell lung cancer cells

  2012cited by this paper
• Preclinical emergence of vandetanib as a potent antitumour agent in mesothelioma: molecular mechanisms underlying its synergistic interaction with pemetrexed and carboplatin

  2011cited by this paper
• Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases

  2011cited by this paper
• Cancer Statistics, 2010

  2010cited by this paper
• Chemoradiotherapy with or without AE-941 in stage III non-small cell lung cancer: a randomized phase III trial.

  2010cited by this paper
• Oncogenic K-Ras turns death receptors into metastasis-promoting receptors in human and mouse colorectal cancer cells.

  2010cited by this paper
• TRAIL-activated stress kinases suppress apoptosis through transcriptional upregulation of MCL-1

  2010cited by this paper
• Mcl‐1; the molecular regulation of protein function

  2010cited by this paper
• New insights into apoptosis signaling by Apo2L/TRAIL

  2010cited by this paper
• TRAIL receptor targeting therapies for non-small cell lung cancer: current status and perspectives.

  2010cited by this paper
• c-Jun N-terminal kinase (JNK) signaling: recent advances and challenges.

  2010cited by this paper
• Differential activation of JNK1 isoforms by TRAIL receptors modulate apoptosis of colon cancer cell lines

  2009cited by this paper
• Polo-Like Kinase-1 Controls Aurora A Destruction by Activating APC/C-Cdh1

  2009cited by this paper
• Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF-induced hepatocyte apoptosis.

  2009cited by this paper
• Imaging systems for westerns: chemiluminescence vs. infrared detection.

  2009cited by this paper
• The complexity of mitogen-activated protein kinases (MAPKs) made simple

  2008cited by this paper
• Identification of RIP1 kinase as a specific cellular target of necrostatins.

  2008cited by this paper
• Bcl2, a transcriptional target of p38α, is critical for neuronal commitment of mouse embryonic stem cells

  2008cited by this paper
• The TRAIL apoptotic pathway in cancer onset, progression and therapy

  2008cited by this paper
• RIP1, a kinase on the crossroads of a cell's decision to live or die

  2007cited by this paper
• TRAIL therapy in non–small cell lung cancer cells: sensitization to death receptor–mediated apoptosis by proteasome inhibitor bortezomib

  2007cited by this paper
• Definitive chemoradiation for the treatment of locally advanced non small-cell lung cancer.

  2007cited by this paper
• TRAIL signalling: decisions between life and death.

  2007cited by this paper
• Different modulation of TRAIL‐induced apoptosis by inhibition of pro‐survival pathways in TRAIL‐sensitive and TRAIL‐resistant colon cancer cells

  2006cited by this paper
• Trail induces cell migration and invasion in apoptosis-resistant cholangiocarcinoma cells.

  2006cited by this paper
• TRAIL receptor-mediated JNK activation and Bim phosphorylation critically regulate Fas-mediated liver damage and lethality.

  2006cited by this paper
• Mechanisms of resistance to TRAIL-induced apoptosis in cancer

  2005cited by this paper
• Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis.

  2005cited by this paper
• Simultaneous blockade of NFkappaB, JNK, and p38 MAPK by a kinase-inactive mutant of the protein kinase TAK1 sensitizes cells to apoptosis and affects a distinct spectrum of tumor necrosis factor [corrected] target genes.

  2005cited by this paper
• Simultaneous Blockade of NFκB, JNK, and p38 MAPK by a Kinase-inactive Mutant of the Protein Kinase TAK1 Sensitizes Cells to Apoptosis and Affects a Distinct Spectrum of Tumor Necrosis Target Genes*

  2005cited by this paper
• Molecular Determinants of Kinase Pathway Activation by Apo2 Ligand/Tumor Necrosis Factor-related Apoptosis-inducing Ligand*

  2005influential reference
• Sensitization of apoptotically-resistant breast carcinoma cells to TNF and TRAIL by inhibition of p38 mitogen-activated protein kinase signaling.

  2004cited by this paper
• MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol

  2004cited by this paper
• Inhibition of the NF-κB pathway enhances TRAIL-mediated apoptosis in neuroblastoma cells

  2004cited by this paper
• Activation of ERK1/2 protects melanoma cells from TRAIL-induced apoptosis by inhibiting Smac/DIABLO release from mitochondria

  2003cited by this paper
• TRAIL Promotes the Survival and Proliferation of Primary Human Vascular Endothelial Cells by Activating the Akt and ERK Pathways

  2003cited by this paper
• Stable suppression of tumorigenicity by virus-mediated RNA interference.

  2002cited by this paper
• TRAIL‐mediated apoptosis requires NF‐kB inhibition and the mitochondrial permeability transition in human hepatoma cells

  2002cited by this paper
• SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

  2001cited by this paper
• The Death Domain Kinase RIP Is Essential for TRAIL (Apo2L)-Induced Activation of IκB Kinase and c-Jun N-Terminal Kinase

  2000cited by this paper
• Activation of a pro‐apoptotic amplification loop through inhibition of NF‐κB‐dependent survival signals by caspase‐mediated inactivation of RIP

  2000cited by this paper
• Chemotherapy triggers apoptosis in a caspase-8-dependent and mitochondria-controlled manner in the non-small cell lung cancer cell line NCI-H460.

  2000cited by this paper
• Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis.

  1999cited by this paper
• Structural basis of inhibitor selectivity in MAP kinases.

  1998cited by this paper
• Pyridinyl Imidazole Inhibitors of p38 Mitogen-activated Protein Kinase Bind in the ATP Site*

  1997cited by this paper

• Differential molecular mechanisms of bortezomib sensitization to rhTRAIL in non-small cell lung cancer cell lines

  2025cites this paper
• HSP90 inhibition reverses resistance to TRAIL-induced apoptosis in non-small cell lung cancer cells

  2025cites this paper
• TNF-Related Apoptosis-Inducing Ligand: Non-Apoptotic Signalling

  2024cites this paper
• Immunomodulatory Functions of TNF-Related Apoptosis-Inducing Ligand in Type 1 Diabetes

  2024cites this paper
• Single-cell RNA sequencing reveals the important role of Dcaf17 in spermatogenesis of golden hamsters

  2024cites this paper
• Homoharringtonine enhances cytarabine-induced apoptosis in acute myeloid leukaemia by regulating the p38 MAPK/H2AX/Mcl-1 axis

  2024cites this paper
• Mechanisms underlying reversed TRAIL sensitivity in acquired bortezomib-resistant non-small cell lung cancer cells

  2024cites this paper
• Differential Effects of Overexpression of Wild Type and Kinase-Dead MELK in Fibroblasts and Keratinocytes, Potential Implications for Skin Wound Healing and Cancer

  2023cites this paper
• Mechanistic insights into the role of FOXO in diabetic retinopathy.

  2022cites this paper
• Stress Relief Techniques: p38 MAPK Determines the Balance of Cell Cycle and Apoptosis Pathways

  2021cites this paper
• Carbon Monoxide-Releasing Molecule-3 Ameliorates Acute Lung Injury in a Model of Hemorrhagic Shock and Resuscitation: Roles of p38MAPK Signaling Pathway

  2020cites this paper
• Napabucasin, a novel inhibitor of STAT3, inhibits growth and synergises with doxorubicin in diffuse large B-cell lymphoma.

  2020cites this paper
• Effect of Acupuncture on the p38 Signaling Pathway in Several Nervous System Diseases: A Systematic Review

  2020cites this paper
• Selective activation of tumor-suppressive MAPKP signaling pathway by triptonide effectively inhibits pancreatic cancer cell tumorigenicity and tumor growth.

  2019cites this paper
• Involvement of p38 Activation and Mitochondria in Death of Human Leukemia Cells Induced by an Agonistic Human Monoclonal Antibody Fab Specific to TRAIL Receptor 1

  2019cites this paper
• Impaired intestinal immune barrier and physical barrier function by phosphorus deficiency: Regulation of TOR, NF‐&kgr;B, MLCK, JNK and Nrf2 signalling in grass carp (Ctenopharyngodon idella) after infection with Aeromonas hydrophila

  2018cites this paper
• In silico prediction of interacting domain of RIP1 with p38 MAPK

  2018cites this paper
• Efficacy of ONC201 in Desmoplastic Small Round Cell Tumor1

  2018cites this paper
• Should We Keep Walking along the Trail for Pancreatic Cancer Treatment? Revisiting TNF-Related Apoptosis-Inducing Ligand for Anticancer Therapy

  2018cites this paper
• The regulation of combined treatment-induced cell death with recombinant TRAIL and bortezomib through TRAIL signaling in TRAIL-resistant cells

  2018cites this paper
• Dioscin inhibits colon cancer cells’ growth by reactive oxygen species-mediated mitochondrial dysfunction and p38 and JNK pathways

  2018cites this paper
• Human Rhinovirus 3C protease cleaves RIPK1, concurrent with caspase 8 activation

  2018cites this paper
• β-catenin decreases acquired TRAIL resistance in non-small-cell lung cancer cells by regulating the redistribution of death receptors.

  2018cites this paper
• Nobiletin inhibits breast cancer via p38 mitogen-activated protein kinase, nuclear transcription factor-κB, and nuclear factor erythroid 2-related factor 2 pathways in MCF-7 cells

  2018cites this paper
• Combinatorial treatment with anacardic acid followed by TRAIL augments induction of apoptosis in TRAIL resistant cancer cells by the regulation of p53, MAPK and NFκβ pathways

  2016cites this paper
• In Vitro Effects of HAS-2 Gene Silencing on the Proliferation and Apoptosis of the MCF-7 Human Breast Cancer Cell Line

  2016cites this paper
• Onto better TRAILs for cancer treatment

  2016cites this paper
• Timosaponin AIII mediates caspase activation and induces apoptosis through JNK1/2 pathway in human promyelocytic leukemia cells

  2015cites this paper
• Heteronemin, a Spongean Sesterterpene, Induces Cell Apoptosis and Autophagy in Human Renal Carcinoma Cells

  2015cites this paper
• Gadd45γ regulates cardiomyocyte death and post-myocardial infarction left ventricular remodelling.

  2015cites this paper
• Surviving apoptosis: life-death signaling in single cells.

  2015cites this paper
• Marine Drugs Regulating Apoptosis Induced by Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)

  2015cites this paper
• 3,4,5‐Tricaffeoylquinic Acid Attenuates TRAIL‐induced Apoptosis in Human Keratinocytes by Suppressing Apoptosis‐related Protein Activation

  2015cites this paper
• Cadmium Induced Apoptosis in MG63 Cells by Increasing ROS, Activation of p38 MAPK and Inhibition of ERK 1/2 Pathways

  2015cites this paper
• Pharmacology and Clinical Development of New Molecularly Targeted Agents

  2015cites this paper
• L'hyperthermie provoque l'agrégation de FLIP et restaure l'apoptose induite par TRAIL

  2014cites this paper
• Dioscin induced activation of p38 MAPK and JNK via mitochondrial pathway in HL-60 cell line.

  2014cites this paper
• Portulacerebroside A induces apoptosis via activation of the mitochondrial death pathway in human liver cancer HCCLM3 cells

  2014cites this paper
• Conventional therapies fail to target inflammation and immune imbalance in subjects with stable coronary artery disease: a system-based approach.

  2014cites this paper
• Synergistic anti-tumor effects of the combination of a benzofuroxan derivate and sorafenib on NCI-H460 human large cell lung carcinoma cells.

  2014cites this paper
• p38 and Extracellular Signal‐Regulated Kinases Activations have Opposite Effects on Primary‐Cultured Rat Cerebellar Granule Neurons Exposed to Sodium Arsenite

  2014cites this paper
• DAPK2 is a novel modulator of TRAIL-induced apoptosis

  2014cites this paper
• A novel compound RY10-4 induces apoptosis and inhibits invasion via inhibiting STAT3 through ERK-, p38-dependent pathways in human lung adenocarcinoma A549 cells.

  2014cites this paper
• Estrogen Regulation of Anti-Apoptotic Bcl-2 Family Member Mcl-1 Expression in Breast Cancer Cells

  2014cites this paper