Temporal regulation of CFTR expression during ovine lung development: implications for CF gene therapy.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Human Molecular Genetics

• Publication date

  2002-01-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/HMG/11.2.125PMID 11809721
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The sheep genome contributes to localization of control elements in a human gene with complex regulatory mechanisms.

  2001cited by this paper
• Epithelial Sodium Channels Regulate Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channels in XenopusOocytes*

  2000cited by this paper
• Inflammation and infection in naive human cystic fibrosis airway grafts.

  2000cited by this paper
• The Cytosolic Termini of the β- and γ-ENaC Subunits Are Involved in the Functional Interactions between Cystic Fibrosis Transmembrane Conductance Regulator and Epithelial Sodium Channel

  2000cited by this paper
• CFTR modulates lung secretory cell proliferation and differentiation.

  2000cited by this paper
• The cytosolic termini of the beta- and gamma-ENaC subunits are involved in the functional interactions between cystic fibrosis transmembrane conductance regulator and epithelial sodium channel.

  2000cited by this paper
• Fas and Fas ligand expression in cystic fibrosis airway epithelium

  1999cited by this paper
• Cloning and functional studies of splice variants of the α-subunit of the amiloride-sensitive Na+ channel.

  1998cited by this paper
• Lung liquid production rates and volumes do not decrease before labor in healthy fetal sheep.

  1997cited by this paper
• Reversal of cystic fibrosis phenotype in mice by gene therapy in utero.

  1997cited by this paper
• Cystic Fibrosis of the Pancreas: Involvement of MUC6 Mucin in Obstruction of Pancreatic Ducts

  1997cited by this paper
• Towards an ovine model of cystic fibrosis.

  1997cited by this paper
• CFTR is involved in membrane endocytosis but not in fluid-phase and receptor-mediated endocytosis in human respiratory epithelial cells.

  1996cited by this paper
• Mutant cystic fibrosis transmembrane conductance regulator inhibits acidification and apoptosis in C127 cells: possible relevance to cystic fibrosis.

  1996cited by this paper
• CFTR regulates outwardly rectifying chloride channels through an autocrine mechanism involving ATP.

  1995cited by this paper
• CFTR as a cAMP-dependent regulator of sodium channels

  1995cited by this paper
• Molecular analysis of the ovine cystic fibrosis transmembrane conductance regulator gene.

  1995cited by this paper
• Expression of the cystic fibrosis gene in adult human lung.

  1994cited by this paper
• Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits

  1994influential reference
• Analysis of mutations and alternative splicing patterns in the CFTR gene using mRNA derived from nasal epithelial cells.

  1994cited by this paper
• Expression of the cystic fibrosis gene in human foetal tissues.

  1993influential reference
• Characterization of the expressed genes for subunit c of mitochondrial ATP synthase in sheep with ceroid lipofuscinosis.

  1993cited by this paper
• Cell-specific localization of CFTR mRNA shows developmentally regulated expression in human fetal tissues.

  1993cited by this paper
• Submucosal glands are the predominant site of CFTR expression in the human bronchus

  1992cited by this paper
• Regulation of plasma membrane recycling by CFTR.

  1992cited by this paper
• Expression of the cystic fibrosis gene in human development.

  1991cited by this paper
• A cystic fibrosis patient who is homozygous for the G85E mutation has very mild disease.

  1991influential reference
• Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA.

  1989cited by this paper
• Identification of the cystic fibrosis gene: Cloning and characterization of complementary DNA

  1989cited by this paper
• Decline in lung liquid volume before labor in fetal lambs.

  1986cited by this paper
• Prenatal diagnosis in 200 pregnancies with a 1-in-4 risk of cystic fibrosis

  1986cited by this paper
• Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.

  1979cited by this paper

• Efficient derivation of stable sheep embryonic stem cells opens a new avenue for agricultural and biomedical application.

  2025cites this paper
• Molecular phenotypes in early gallbladder and liver disease in the CFTR-/-sheep highlight aspects of CF-relevant hepatobiliary disease.

  2025cites this paper
• Overexpression of CYP6CY1 is Involved in Imidacloprid Resistance in Sitobion miscanthi (Takahashi) (Homoptera: Aphidae)

  2025cites this paper
• Overexpression of SmUGGT1 Confers Imidacloprid Resistance to Sitobion miscanthi (Takahashi).

  2024cites this paper
• microRNA-3037 targeting CYP6CY2 confers imidacloprid resistance to Sitobion miscanthi (Takahashi).

  2024cites this paper
• Transcriptomic analysis of lung development in wildtype and CFTR−/− sheep suggests an early inflammatory signature in the CF distal lung

  2023cites this paper
• CYP4CJ6-mediated resistance to two neonicotinoid insecticides in Sitobion miscanthi (Takahashi)

  2022cites this paper
• Early developmental phenotypes in the cystic fibrosis sheep model

  2022cites this paper
• MicroRNA-263b confers imidacloprid resistance in Sitobion miscanthi (Takahashi) by regulating the expression of the nAChRβ1 subunit.

  2022cites this paper
• Molecular regulation of lung maturation in near-term fetal sheep by maternal daily vitamin C treatment in late gestation

  2021cites this paper
• CFTR Cooperative Cis-Regulatory Elements in Intestinal Cells

  2021cites this paper
• Elexacaftor/Tezacaftor/Ivacaftor alters branching morphogenesis of the mouse embryonic lung

  2021cites this paper
• Sheep models of F508del and G542X cystic fibrosis mutations show cellular responses to human therapeutics

  2021cites this paper
• OTX2 regulates CFTR expression during endoderm differentiation and occupies 3′ cis‐regulatory elements

  2021cites this paper
• Promoters of the two novel cytochrome P450 genes, CYP6DD1 and CYP307A2 from Sitobion miscanthi and their mediation under insecticide exposure

  2021cites this paper
• What Role Does CFTR Play in Development, Differentiation, Regeneration and Cancer?

  2020cites this paper
• Looping of upstream cis-regulatory elements is required for CFTR expression in human airway epithelial cells

  2020cites this paper
• CFTR fragments with the F508 deletion exert a dual allosteric control over the master kinase CK2.

  2020cites this paper
• Postnatal decrease of cystic fibrosis transmembrane conductance regulator gene expression in nasal epithelium of healthy newborn infants

  2019cites this paper
• Cell-Selective Regulation of CFTR Gene Expression: Relevance to Gene Editing Therapeutics

  2019cites this paper
• A sheep model of cystic fibrosis generated by CRISPR/Cas9 disruption of the CFTR gene.

  2018cites this paper
• Lack of cystic fibrosis transmembrane conductance regulator disrupts fetal airway development in pigs

  2018cites this paper
• A transcription factor network represses CFTR gene expression in airway epithelial cells.

  2018cites this paper
• CFTR and Cystic Fibrosis: From Structure to Function

  2018cites this paper
• Radiographic assessment of lung anatomy, physiology, and disease in a porcine model of cystic fibrosis and people with cystic fibrosis

  2017cites this paper
• Postnatal airway growth in cystic fibrosis piglets.

  2017cites this paper
• Roadmap for an early gene therapy for cystic fibrosis airway disease

  2017cites this paper
• Deep resequencing of CFTR in 762 F508del homozygotes reveals clusters of non-coding variants associated with cystic fibrosis disease traits

  2016cites this paper
• The extracellular calcium-sensing receptor regulates human fetal lung development via CFTR

  2016cites this paper
• THE MOLECULAR ETIOLOGY OF ATYPICAL CYSTIC FIBROSIS & PHENOTYPIC HETEROGENEITY IN CLASSIC CYSTIC FIBROSIS

  2016cites this paper
• Glucocorticoids Distinctively Modulate the CFTR Channel with Possible Implications in Lung Development and Transition into Extrauterine Life

  2015influential citation
• Identification d'éléments régulateurs du gène CFTR et applications pour la mucoviscidose

  2015cites this paper
• Role of Non-coding RNAs in Cystic Fibrosis

  2015cites this paper
• Chromatin Dynamics in the Regulation of CFTR Expression

  2015cites this paper
• Development of Salt and Water Transport across Airway and Alveolar Epithelia

  2014cites this paper
• Transcription factors and miRNAs that regulate fetal to adult CFTR expression change are new targets for cystic fibrosis

  2014cites this paper
• Dynamics of short- and long-term association between a bacterial plant pathogen and its arthropod vector

  2014cites this paper
• A balance between activating and repressive histone modifications regulates cystic fibrosis transmembrane conductance regulator (CFTR) expression in vivo

  2014cites this paper
• Air trapping and airflow obstruction in newborn cystic fibrosis piglets.

  2013cites this paper
• Heliothine caterpillars differ in abundance of a gut lumen aminoacylase (L-ACY-1)-Suggesting a relationship between host preference and fatty acid amino acid conjugate metabolism.

  2012cites this paper
• Dexamethasone Regulates CFTR Expression in Calu-3 Cells with the Involvement of Chaperones HSP70 and HSP90

  2012cites this paper
• Sex steroid hormone effects in normal and pathologic conditions in lung physiology.

  2012cites this paper
• Risks, benefits and ethical, legal, and societal considerations for translation of prenatal gene therapy to human application.

  2012cites this paper
• Gene and cell therapy for cystic fibrosis: from bench to bedside.

  2011cites this paper
• Epithelial membrane transporters expression in the developing to adult mouse vomeronasal organ and olfactory mucosa

  2011cites this paper
• Cystic fibrosis transmembrane regulator fragments with the Phe508 deletion exert a dual allosteric control over the master kinase CK2.

  2010cites this paper
• Multiple mechanisms influence regulation of the cystic fibrosis transmembrane conductance regulator gene promoter.

  2010cites this paper
• Transient in utero disruption of Cystic Fibrosis Transmembrane Conductance Regulator causes phenotypic changes in Alveolar Type II cells in adult rats

  2009cites this paper
• Expression of ENaC subunits, chloride channels, and aquaporins in ovine fetal lung: ontogeny of expression and effects of altered fetal cortisol concentrations.

  2009influential citation
• Polymerase Chain Reaction and Reverse Transcription-Polymerase Chain Reaction

  2009cites this paper
• Novel regulatory mechanisms for the CFTR gene.

  2009cites this paper
• An insulator element 3′ to the CFTR gene binds CTCF and reveals an active chromatin hub in primary cells

  2009cites this paper
• Developmental Regulation of the type-A Gamma-Aminobutyric Acid Receptor (GABA-AR) Signaling in the Fetal Rat Lung

  2009cites this paper
• Lubiprostone activates non-CFTR-dependent respiratory epithelial chloride secretion in cystic fibrosis mice.

  2008cites this paper
• Alterations in S-adenosylhomocysteine metabolism decrease O6-methylguanine DNA methyltransferase gene expression without affecting promoter methylation.

  2008cites this paper
• CFTR and Wnt/beta-catenin signaling in lung development

  2008influential citation
• EMBRYONIC LUNG GROWTH IS NORMAL IN A cftr-KNOCKOUT MOUSE MODEL

  2008cites this paper
• Lokalisation und Expression der S-Adenosylhomocystein-Hydrolase und des Adenosin- A1-Rezeptors in der Rattenniere unter Kontroll- und pathologischen Bedingungen

  2008cites this paper
• The impact of sex and sex hormones on lung physiology and disease: lessons from animal studies.

  2007cites this paper
• Evolution of CFTR protein distribution in lung tissue from normal and CF human fetuses

  2007cites this paper
• Role of S-adenosylhomocysteine hydrolase in adenosine-induced apoptosis in HepG2 cells.

  2007cites this paper
• Cystic Fibrosis and Formes Frustes of CFTR-Related Disease

  2007cites this paper
• Klinische Studie zum Vergleich von Einzelverläufen i.v.- antibiotischer Therapie bei CF-Patienten mit Ceftazidim und Tobramycin unter pharmakodynamischer Variation

  2007cites this paper
• CFTR gene therapy, a method to rescue lung hypoplasia in congenital diaphragmatic hernia?

  2006cites this paper
• Human-specific cystic fibrosis transmembrane conductance regulator antibodies detect in vivo gene transfer to ovine airways.

  2006cites this paper
• Addressing fluorogenic real-time qPCR inhibition using the novel custom Excel file system 'FocusField2-6GallupqPCRSet-upTool-001' to attain consistently high fidelity qPCR reactions

  2006cites this paper
• Gene and cell therapy for cystic fibrosis.

  2006cites this paper
• Chloride transporters and vacuolar H+-ATPase in nephrogenesis and congenital tubulopathies

  2006cites this paper
• Phytohormones in Arabidopsis thaliana during Pseudomonas syringae infection.

  2006cites this paper
• Gene therapy for cystic fibrosis airway disease- is clinical success imminent?

  2006cites this paper
• Cystic fibrosis transmembrane conductance regulator (CFTR) dependent cytoskeletal tension during lung organogenesis

  2006cites this paper
• Human specific CFTR antibodies detect in vivo gene transfer to ovine airways

  2006cites this paper
• Pathophysiologic consequences following inhibition of a CFTR-dependent developmental cascade in the lung

  2005cites this paper
• The CFTR gene and regulation of its expression

  2005cites this paper
• Entwicklung von DNA- und Expressions-Markern zum Nachweis von menschlichen künstlichen Chromosomen und in vivo Transfektionsanalyse verbesserter HAC Vektoren

  2005cites this paper
• New quick method for isolating RNA from laser captured cells stained by immunofluorescent immunohistochemistry; RNA suitable for direct use in fluorogenic TaqMan one-step real-time RT-PCR

  2005cites this paper
• Developmental Paradigm for Early Features of Cystic Fibrosis

  2005cites this paper
• Influence of an altered methylation potential on mRNA methylation and gene expression in HepG2 cells.

  2004cites this paper
• The "Goldilocks Effect" in Cystic Fibrosis: identification of a lung phenotype in the cftr knockout and heterozygous mouse

  2004cites this paper
• MUC5AC and MUC5B Mucins Are Decreased in Cystic Fibrosis Airway Secretions.

  2004cites this paper
• Basic science of cystic fibrosis

  2003cites this paper
• Alternative 5' exons of the CFTR gene show developmental regulation.

  2003cites this paper
• Modulation of Sp1 and Sp3 in lung epithelial cells regulates ClC-2 chloride channel expression.

  2003cites this paper
• Novel MUC1 splice variants contribute to mucin overexpression in CFTR-deficient mice.

  2003cites this paper
• Autosomal dominant polycystic kidney disease: molecular genetics and pathophysiology.

  2003cites this paper
• Alternative splicing of the ovine CFTR gene

  2003cites this paper
• Cystic fibrosis: more questions than answers.

  2003cites this paper
• Theoretical Biology and Medical Modelling Open Access the Peter Pan Paradigm Background

  year unknowncites this paper
• Sheep Models of F508del and G542X Cystic Fibrosis Mutations Sheep Models of F508del and G542X Cystic Fibrosis Mutations Show Cellular Responses to Human Therapeutics Show Cellular Responses to Human Therapeutics

  year unknowncites this paper