Regulation of Kindling Epileptogenesis by Hippocampal Galanin Type 1 and Type 2 Receptors: The Effects of Subtype-Selective Agonists and the Role of G-Protein-Mediated Signaling

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Journal of Pharmacology and Experimental Therapeutics

• Publication date

  2006-08-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1124/jpet.106.104703PMID 16699066
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Galanin and its receptors in neurological disorders

  2007cited by this paper
• Regulation of limbic status epilepticus by hippocampal galanin type 1 and type 2 receptors.

  2005cited by this paper
• Galanin (2-11) binds to GalR3 in transfected cell lines: limitations for pharmacological definition of receptor subtypes.

  2005cited by this paper
• Role of galanin receptor 1 and galanin receptor 2 activation in synaptic plasticity associated with 3',5'-cyclic AMP response element-binding protein phosphorylation in the dentate gyrus: studies with a galanin receptor 2 agonist and galanin receptor 1 knockout mice.

  2005cited by this paper
• In vivo interaction between serotonin and galanin receptors types 1 and 2 in the dorsal raphe: implication for limbic seizures

  2005cited by this paper
• A Galanin Receptor Subtype 1 Specific Agonist

  2005cited by this paper
• The cannabinoid agonist WIN55,212-2 increases intracellular calcium via CB1 receptor coupling to Gq/11 G proteins.

  2005influential reference
• Kindling and status epilepticus models of epilepsy: rewiring the brain.

  2004cited by this paper
• Galanin type 2 receptors regulate neuronal survival, susceptibility to seizures and seizure‐induced neurogenesis in the dentate gyrus

  2004cited by this paper
• Patterns of seizures, hippocampal injury and neurogenesis in three models of status epilepticus in galanin receptor type 1 (GalR1) knockout mice.

  2004cited by this paper
• Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests.

  2004cited by this paper
• Therapy Discovery for Pharmacoresistant Epilepsy and for Disease‐modifying Therapeutics: Summary of the NIH/NINDS/AES Models II Workshop

  2003cited by this paper
• Glutamate metabotropic receptors as targets for drug therapy in epilepsy.

  2003cited by this paper
• Molecular mechanisms mediating inhibition of G protein-coupled inwardly-rectifying K+ channels.

  2003cited by this paper
• Interactions between Sec complex and prepro-alpha-factor during posttranslational protein transport into the endoplasmic reticulum.

  2003cited by this paper
• Attenuation of seizures and neuronal death by adeno-associated virus vector galanin expression and secretion

  2003cited by this paper
• Recombinant AAV‐mediated expression of galanin in rat hippocampus suppresses seizure development

  2003cited by this paper
• Critical role for GALR1 galanin receptor in galanin regulation of neuroendocrine function and seizure activity.

  2002cited by this paper
• Galanin inhibits tyrosine hydroxylase expression in midbrain dopaminergic neurons

  2002cited by this paper
• Potassium channels as anti-epileptic drug targets.

  2002influential reference
• Restricted distribution of galanin receptor 3 (GalR3) mRNA in the adult rat central nervous system.

  2002cited by this paper
• Animal models of epilepsy for the development of antiepileptogenic and disease-modifying drugs. A comparison of the pharmacology of kindling and post-status epilepticus models of temporal lobe epilepsy.

  2002influential reference
• Suppressed kindling epileptogenesis in mice with ectopic overexpression of galanin

  2001cited by this paper
• Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: Selective actions via GalR1 and GalR2 receptors

  2001cited by this paper
• [d-Arg1,d-Trp5,7,9,Leu11]Substance P Inhibits Bombesin-induced Mitogenic Signal Transduction Mediated by Both Gq and G12 in Swiss 3T3 Cells*

  2000cited by this paper
• Modulation of Hippocampal Excitability and Seizures by Galanin

  2000cited by this paper
• [D-Arg(1),D-Trp(5,7,9),Leu(11)]Substance P inhibits bombesin-induced mitogenic signal transduction mediated by both G(q) and G(12) in Swiss 3T3cells.

  2000cited by this paper
• Temporal profile of CRE DNA-binding activity in the rat hippocampus following a kindling stimulation.

  2000cited by this paper
• Expression of the novel galanin receptor subtype GALR2 in the adult rat CNS: Distinct distribution from GALR1

  1999cited by this paper
• Substance P is expressed in hippocampal principal neurons during status epilepticus and plays a critical role in the maintenance of status epilepticus.

  1999cited by this paper
• A novel high-affinity inhibitor for inward-rectifier K+ channels.

  1998cited by this paper
• Galanin Modulation of Seizures and Seizure Modulation of Hippocampal Galanin in Animal Models of Status Epilepticus

  1998cited by this paper
• Differential intracellular signaling of the GalR1 and GalR2 galanin receptor subtypes.

  1998influential reference
• The contribution of endogenous mono-ADP-ribosylation to kindling-induced epileptogenesis.

  1997cited by this paper
• Binding and agonist/antagonist actions of M35, galanin(1-13)-bradykinin(2-9)amide chimeric peptide, in Rin m 5F insulinoma cells.

  1995cited by this paper
• Differential Modulation of Bombesin-stimulated Phospholipase Cβ and Mitogen-activated Protein Kinase Activity by [D-Arg1, D-Phe5, D-Trp7,9,Leu11>]Substance P (*)

  1995cited by this paper
• Suppression of kindled seizure following intraamygdaloid injection of pertussis toxin in rats.

  1991cited by this paper
• A pertussis toxin-sensitive G protein in hippocampal long-term potentiation.

  1989cited by this paper
• A pertussis toxin sensitive G protein mediates dihydropyridine inhibition of maitotoxin stimulated calcium flux in 235-1 pituitary clone

  1988cited by this paper
• Kindling with rapidly recurring hippocampal seizures.

  1985cited by this paper
• Identification of the predominant substrate for ADP-ribosylation by islet activating protein.

  1983cited by this paper
• The Rat Brain in Stereotaxic Coordinates

  1983cited by this paper
• Neuronal supersensitivity to acetylcholine induced by kindling in the rat hippocampus.

  1979cited by this paper

• Galanin Inhibits Histaminergic Neurons via Galanin Receptor 1

  2026cites this paper
• Galanin receptors in GtoPdb v.2025.1

  2025cites this paper
• Galanin receptors in GtoPdb v.2025.3

  2025cites this paper
• Direct modulation of G protein-gated inwardly rectifying potassium (GIRK) channels

  2024cites this paper
• G protein-gated inwardly rectifying K+ (GIRK/Kir3) channels: Molecular, cellular, and subcellular diversity.

  2024cites this paper
• Impairments in hippocampal oscillations accompany the loss of LTP induced by GIRK activity blockade

  2023cites this paper
• Neuromedin B excites central lateral amygdala neurons and reduces cardiovascular output and fear‐potentiated startle

  2023cites this paper
• Neuronal diversity of neuropeptide signaling, including galanin, in the mouse locus coeruleus

  2023cites this paper
• Structural insights in the permeation mechanism of an activated GIRK2 channel.

  2023cites this paper
• Synergistic effects of the galanin analog 810–2 with the antiseizure medication levetiracetam in rodent seizure models

  2022cites this paper
• Ionic signalling mechanisms involved in neurokinin‐3 receptor‐mediated augmentation of fear‐potentiated startle response in the basolateral amygdala

  2022influential citation
• Neuroanatomical characterization of the G protein-coupled receptor activity evoked by galanin-related ligands.

  2022cites this paper
• Galanin receptors in GtoPdb v.2021.2

  2021cites this paper
• Envisioning the role of inwardly rectifying potassium (Kir) channel in epilepsy

  2021cites this paper
• Kir Channel Molecular Physiology, Pharmacology, and Therapeutic Implications.

  2021cites this paper
• Insights into Potential Targets for Therapeutic Intervention in Epilepsy

  2020cites this paper
• Beneficial effects of galanin system on diabetic peripheral neuropathic pain and its complications.

  2020cites this paper
• Lactate reduces epileptiform activity through HCA1 and GIRK channel activation in rat subicular neurons in an in vitro model

  2019cites this paper
• Galanin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

  2019cites this paper
• Ion Channels in Epilepsy: Blasting Fuse for Neuronal Hyperexcitability

  2019cites this paper
• Roles of K+ and cation channels in ORL‐1 receptor‐mediated depression of neuronal excitability and epileptic activities in the medial entorhinal cortex

  2019cites this paper
• GIRK1-mediated inwardly rectifying potassium current suppresses the epileptiform burst activities and the potential antiepileptic effect of ML297.

  2018cites this paper
• Neuroanatomical Localization of Galanin in Zebrafish Telencephalon and Anticonvulsant Effect of Galanin Overexpression.

  2018cites this paper
• Dorsal hippocampal galanin modulates anxiety-like behaviours in rats.

  2018cites this paper
• Effects of galanin receptor 2 and receptor 3 knockout in mouse models of acute seizures

  2018influential citation
• Expression of cardiac inwardly rectifying potassium channels in pentylenetetrazole kindling model of epilepsy in rats.

  2018cites this paper
• Regulation of kindling epileptogenesis by hippocampal Toll‐like receptors 2

  2017cites this paper
• Inhibition of 17-beta-estradiol on neuronal excitability via enhancing GIRK1-mediated inwardly rectifying potassium currents and GIRK1 expression.

  2017cites this paper
• Preclinical evaluation of intravenous NAX 810‐2, a novel GalR2‐preferring analog, for anticonvulsant efficacy and pharmacokinetics

  2017cites this paper
• Galanin contributes to monoaminergic dysfunction and to dependent neurobehavioral comorbidities of epilepsy

  2017cites this paper
• Hippocampal Transcriptomic Profiles: Subfield Vulnerability to Age and Cognitive Impairment

  2017cites this paper
• Kindling: A Model and Phenomenon of Epilepsy

  2017cites this paper
• Models of Depression

  2017cites this paper
• Myocardial protection from ischemia/reperfusion injury by exogenous galanin fragment

  2017cites this paper
• A KCNJ6 gene polymorphism modulates theta oscillations during reward processing.

  2017cites this paper
• The novel anticonvulsant neuropeptide and galanin analogue, NAX‐5055, does not alter energy and amino acid metabolism in cultured brain cells

  2017cites this paper
• Pharmacological stimulation of GAL1R but not GAL2R attenuates kainic acid-induced neuronal cell death in the rat hippocampus.

  2016cites this paper
• Galanin - ReadingSample

  2016cites this paper
• Galanin subtype 1 and subtype 2 receptors mediate opposite anxiety-like effects in the rat dorsal raphe nucleus.

  2016cites this paper
• Development of Spexin-based Human Galanin Receptor Type II-Specific Agonists with Increased Stability in Serum and Anxiolytic Effect in Mice

  2016cites this paper
• Gene Therapy for Epilepsy

  2016cites this paper
• Potassium Channels and Human Epileptic Phenotypes: An Updated Overview

  2016cites this paper
• Behavioral and Genetic Evidence for GIRK Channels in the CNS: Role in Physiology, Pathophysiology, and Drug Addiction.

  2015cites this paper
• G protein-gated inwardly rectifying potassium channel subunits 1 and 2 are down-regulated in rat dorsal root ganglion neurons and spinal cord after peripheral axotomy

  2015cites this paper
• Type 2 diabetes mellitus, drug addiction, bipolar disorder and epilepsy display overlapping aetiopathogenic mechanisms: Implication for prevention and pharmacotherapy

  2015cites this paper
• Potential mechanisms and clinical applications of mild hypothermia and electroconvulsive therapy on refractory status epilepticus

  2015cites this paper
• Activation of galanin receptor 2 stimulates large conductance Ca(2+)-dependent K(+) (BK) channels through the IP3 pathway in human embryonic kidney (HEK293) cells.

  2014cites this paper
• Alcohol modulation of G-protein-gated inwardly rectifying potassium channels: from binding to therapeutics

  2014cites this paper
• A Molecular Approach to Epilepsy Management: from Current Therapeutic Methods to Preconditioning Efforts

  2014cites this paper
• fficacy and tolerability of the galanin nalog NAX 5055 in the multiple-hit rat odel of symptomatic infantile spasms

  2013cites this paper
• K+ channelepsy: progress in the neurobiology of potassium channels and epilepsy

  2013cites this paper
• Progress report on new antiepileptic drugs: a summary of the Eleventh Eilat Conference (EILAT XI).

  2013cites this paper
• Positive allosteric modulators to peptide GPCRs: a promising class of drugs

  2013cites this paper
• Pathogenesis of Epilepsy: Challenges in Animal Models

  2013cites this paper
• Sudomotor function and sweat gland innervation in galanin knockout mice.

  2012cites this paper
• Peripheral Galanin Receptor 2 as a Target for the Modulation of Pain

  2012cites this paper
• Galanin Receptors and Ligands

  2012cites this paper
• RGS Proteins Maintain Robustness of GPCR-GIRK Coupling by Selective Stimulation of the G Protein Subunit Gαo

  2012cites this paper
• Regulators of synaptic transmission: Roles in the pathogenesis and treatment of epilepsy

  2012cites this paper
• Conserved toxic responses across divergent phylogenetic lineages: a meta-analysis of the neurotoxic effects of RDX among multiple species using toxicogenomics

  2011cites this paper
• Emerging concepts for G protein-gated inwardly rectifying potassium ( GIRK ) channels in health and disease

  2011cites this paper
• The omega‐3 fatty acid–derived neuroprotectin D1 limits hippocampal hyperexcitability and seizure susceptibility in kindling epileptogenesis

  2011cites this paper
• Galanin, galanin receptors, and drug targets.

  2010cites this paper
• Binding of Chimeric Peptides M617 and M871 to Galanin Receptor Type 3 Reveals Characteristics of Galanin Receptor–Ligand Interaction

  2010cites this paper
• Regulation of the galanin system by repeated electroconvulsive seizures in mice

  2010cites this paper
• Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic delivery.

  2010cites this paper
• Evaluation of development‐specific targets for antiepileptogenic therapy using rapid kindling

  2010cites this paper
• K. Mitsukawa, X. Lu, and T. Bartfai

  2010cites this paper
• Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease

  2010cites this paper
• Prevention or Modification of Epileptogenesis after Brain Insults: Experimental Approaches and Translational Research

  2010cites this paper
• Neuroprotective role for galanin in Alzheimer's disease.

  2010cites this paper
• GalR2-positive allosteric modulator exhibits anticonvulsant effects in animal models

  2010cites this paper
• Progress report on new antiepileptic drugs: a summary of the Tenth Eilat Conference (EILAT X).

  2010cites this paper
• Galanin Receptor 1 Deletion Exacerbates Hippocampal Neuronal Loss after Systemic Kainate Administration in Mice

  2010cites this paper
• Galanin and epilepsy.

  2010cites this paper
• Donepezil and galanin interactions in an animal model of Alzheimer’s disease

  2010cites this paper
• Structural requirements for a lipoamino acid in modulating the anticonvulsant activities of systemically active galanin analogues.

  2009cites this paper
• A novel GalR2-specific peptide agonist.

  2009cites this paper
• New and investigational antiepileptic drugs

  2009cites this paper
• PEPTIDES | Galanin Modulation of Epileptogenicity

  2009cites this paper
• Galanin receptor ligands

  2009influential citation
• Developing novel antiepileptic drugs: Characterization of NAX 5055, a systemically-active galanin analog, in epilepsy models

  2009cites this paper
• Progress report on new antiepileptic drugs: a summary of the Ninth Eilat Conference (EILAT IX).

  2009cites this paper
• Twenty-Five Years of Galanin Research

  2009cites this paper
• Variation in Galr1 expression determines susceptibility to excitotoxin‐induced cell death in mice

  2008cites this paper
• Antiepileptogenic and antiictogenic effects of retigabine under conditions of rapid kindling: An ontogenic study

  2008cites this paper
• Galanin – 25 years with a multitalented neuropeptide

  2008cites this paper
• Chapter 4.1 Peptide receptor ligands to treat anxiety disorders

  2008cites this paper
• Novel AAV-mediated therapeutic strategies for epilepsy

  2008cites this paper
• Galanin-2-11-NH 2

  2008cites this paper
• Galanin – 25 years with a multitalented neuropeptide

  2008cites this paper
• Galanin – 25 years with a multitalented neuropeptide

  2008cites this paper
• Design, synthesis, and characterization of high-affinity, systemically-active galanin analogues with potent anticonvulsant activities.

  2008cites this paper
• Effects of Bisphenol-A and Other Endocrine Disruptors Compared With Abnormalities of Schizophrenia: An Endocrine-Disruption Theory of Schizophrenia

  2008cites this paper
• Galanin – 25 years with a multitalented neuropeptide

  2008cites this paper
• Frontiers in Research Reviews: Adult Neurogenesis in the Healthy and Dysfunctional Brain REGULATORS OF ADULT NEUROGENESIS IN THE HEALTHY AND DISEASED BRAIN

  2007cites this paper
• Galanin gene transfer curtails generalized seizures in kindled rats without altering hippocampal synaptic plasticity.

  2007cites this paper
• Kindling epileptogenesis in immature rats leads to persistent depressive behavior.

  2007cites this paper
• Subtype selective activation and molecular characterization of galanin receptors

  2007cites this paper
• The effect of methamphetamine on seizure threshold and epileptogenesis.

  2007cites this paper