Ecology‐based screen identifies new metabolites from a Cordyceps‐colonizing fungus as cancer cell proliferation inhibitors and apoptosis inducers

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Cell Proliferation

• Publication date

  2009-12-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1111/j.1365-2184.2009.00636.xPMID 19673894PMCID PMC6496219
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The solid state, solution and tubulin-bound conformations of agents that promote microtubule stabilization.

  2012cited by this paper
• Ready for a comeback of natural products in oncology.

  2009cited by this paper
• Cordyceps – A traditional Chinese medicine and another fungal therapeutic biofactory?

  2008cited by this paper
• Diagnosing and exploiting cancer's addiction to blocks in apoptosis

  2008cited by this paper
• Cytotoxic drug-induced, p53-mediated upregulation of caspase-8 in tumor cells

  2008cited by this paper
• Antitumor Activity of Rapamycin in a Phase I Trial for Patients with Recurrent PTEN-Deficient Glioblastoma

  2008cited by this paper
• Chloropupukeananin, the first chlorinated pupukeanane derivative, and its precursors from Pestalotiopsis fici.

  2008cited by this paper
• Apoptotic pathways in tumor progression and therapy.

  2008cited by this paper
• Cancer Statistics, 2008

  2008cited by this paper
• Mechanistic studies on bleomycin-mediated DNA damage: multiple binding modes can result in double-stranded DNA cleavage

  2008cited by this paper
• Novel cytotoxic drugs: old challenges, new solutions.

  2008cited by this paper
• Chemical ecology in retrospect and prospect

  2008cited by this paper
• Natural products as sources of new drugs over the last 25 years.

  2007influential reference
• Chaetocin: a promising new antimyeloma agent with in vitro and in vivo activity mediated via imposition of oxidative stress.

  2007cited by this paper
• Bioactive p-terphenyl derivatives from a Cordyceps-colonizing isolate of Gliocladium sp.

  2007cited by this paper
• Applications of Fungal Ecology in the Search for New Bioactive Natural Products

  2007cited by this paper
• Geldanamycins Trigger a Novel Ron Degradative Pathway, Hampering Oncogenic Signaling*

  2006cited by this paper
• Drug Insight: cancer therapy strategies based on restoration of endogenous cell death mechanisms

  2006cited by this paper
• 11,11′-Dideoxy-verticillin: a natural compound possessing growth factor receptor tyrosine kinase-inhibitory effect with anti-tumor activity

  2005influential reference
• Antiangiogenic activity of 11,11'-dideoxyverticillin, a natural product isolated from the fungus Shiraia bambusicola.

  2005cited by this paper
• Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis

  2004cited by this paper
• Gliotoxin is a dual inhibitor of farnesyltransferase and geranylgeranyltransferase I with antitumor activity against breast cancer in vivo

  2004cited by this paper
• ANTITUMOUR ACTIVITY OF CORDYCEPIN IN MICE

  2004cited by this paper
• Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors

  2003cited by this paper
• Induction of Differentiation in Acute Promyelocytic Leukemia Cells (HL-60) by the Verticillin Derivative Sch 52900

  2002cited by this paper
• Natural products in anticancer therapy.

  2001cited by this paper
• Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase.

  2001cited by this paper
• Regulation of the G2/M transition by p53

  2001cited by this paper
• The synthesis, discovery, and development of a highly promising class of microtubule stabilization agents: Curative effects of desoxyepothilones B and F against human tumor xenografts in nude mice

  2001cited by this paper
• In vivo site specificity and human isoenzyme selectivity of two topoisomerase II-poisoning anthracyclines.

  2000cited by this paper
• A common pharmacophore for cytotoxic natural products that stabilize microtubules.

  1999cited by this paper
• Nuclear Accumulation of p21Cip1 at the Onset of Mitosis: a Role at the G2/M-Phase Transition

  1998cited by this paper
• Signal-transduction cascades as targets for therapeutic intervention by natural products.

  1998cited by this paper
• The Scientific Rediscovery of an Ancient Chinese Herbal Medicine: Cordyceps sinensis Part I

  1998cited by this paper
• Tumor suppressor p53 is a direct transcriptional activator of the human bax gene.

  1995cited by this paper
• Cancer statistics

  1989cited by this paper

• Culture-dependent and -independent analyses reveal unique community structure and function in the external mycelial cortices of Ophiocordyceps sinensis

  2025cites this paper
• Ni-Catalyzed Thioetherification of Alkyl and Aryl Thiols With Aryl Bromides Under Base-Free Condition.

  2025cites this paper
• The Cordyceps Genus as a Potential Source of Bioactive Compounds for Adjuvant Cancer Therapy: A Network Pharmacology Approach

  2025cites this paper
• Verticillins: fungal epipolythiodioxopiperazine alkaloids with chemotherapeutic potential

  2024cites this paper
• Microorganism‐Derived Bisindole Alkaloids With Anticancer Potential and Their Mechanisms: A Comprehensive Review

  2024cites this paper
• Endophytic fungi: A future prospect for breast cancer therapeutics and drug development

  2024cites this paper
• Rogersonins C-F, 9H-Imidazo[2,1-i]purine-Incorporating Adenine-Polyketide Hybrids from an Ophiocordyceps-Associated Clonostachys rogersoniana.

  2024cites this paper
• The disulphide cleavage derivative (C42-4) of 11′-deoxyverticillin A (C42) fails to induce apoptosis and genomic instability in HeLa cells

  2023cites this paper
• Unearthing diverse culturable fungal communities associated with Ophiocordyceps indica sp. nov. from Indian Western Himalaya

  2023cites this paper
• Natural epidithiodiketopiperazine alkaloids as potential anticancer agents: Recent mechanisms of action, structural modification, and synthetic strategies.

  2023cites this paper
• Bio prospecting of Lapachol producing endophytic fungi

  2022cites this paper
• Bispyrrolidinoindoline Epi(poly)thiodioxopiperazines (BPI-ETPs) and Simplified Mimetics: Structural Characterization, Bioactivities, and Total Synthesis

  2022cites this paper
• Putative Anticancer Compounds from Plant-Derived Endophytic Fungi: A Review

  2022cites this paper
• Diversity of Cordyceps from Different Environmental Agroecosystems and Potential Applications

  2021cites this paper
• Complex microbial communities inhabiting natural Cordyceps militaris and the habitat soil and their predicted functions

  2021cites this paper
• Chaetocochin J, an epipolythiodioxopiperazine alkaloid, induces apoptosis and autophagy in colorectal cancer via AMPK and PI3K/AKT/mTOR pathways.

  2021cites this paper
• Antitumor and Immunomodulatory Compounds from Fungi

  2021cites this paper
• Disulfide Cleavage in a Dimeric Epipolythiodioxopiperazine Natural Product Diminishes Its Apoptosis-Inducing Effect but Enhances Autophagy in Tumor Cells.

  2020cites this paper
• Uncovering fungal community composition in natural habitat of Ophiocordyceps sinensis using high-throughput sequencing and culture-dependent approaches

  2020cites this paper
• The disruption of verM activates the production of gliocladiosin A and B in Clonostachys rogersoniana.

  2019cites this paper
• Antibacterial diketopiperazines from an endophytic fungus Bionectria sp. Y1085

  2019cites this paper
• Thiodiketopiperazines with two spirocyclic centers extracted from Botryosphaeria mamane, an endophytic fungus isolated from Bixa orellana L.

  2019cites this paper
• Rogersonins A and B, Imidazolone N-Oxide-Incorporating Indole Alkaloids from a verG Disruption Mutant of Clonostachys rogersoniana.

  2019cites this paper
• Media studies to enhance the production of verticillins facilitated by in situ chemical analysis

  2018cites this paper
• Hawaiienols A-D, Highly Oxygenated p-Terphenyls from an Insect-Associated Fungus, Paraconiothyrium hawaiiense.

  2018cites this paper
• Bioprospecting of Endophytic Fungi for Bioactive Compounds

  2018cites this paper
• Endophytic Fungi as Alternative and Reliable Sources for Potent Anticancer Agents

  2017cites this paper
• Punctaporonins N–S, New Caryophyllene Sesquiterpenoids from Cytospora sp.

  2017cites this paper
• Identification and characterization of the verticillin biosynthetic gene cluster in Clonostachys rogersoniana.

  2017cites this paper
• VerZ, a Zn(II)2Cys6 DNA-binding protein, regulates the biosynthesis of verticillin in Clonostachys rogersoniana.

  2017cites this paper
• Identification and Bioactive Potential of Endogenetic Fungi Isolated from Medicinal Caterpillar Fungus Ophiocordyceps sinensis from Tibetan Plateau

  2017cites this paper
• Endophytes: Potential Source of Therapeutically Important Secondary Metabolites of Plant Origin

  2017cites this paper
• CORDYCEPS, AN ENDANGERED MEDICINAL PLANT: A SHORT REVIEW

  2017cites this paper
• ISOLATION AND CHARACTERIZATION OF FUNGAL ENDOPHYTES FROM CERTAIN MEDICINAL PLANTS AND RET SPECIES IN WESTERN GHATS AND THEIR THERAPEUTIC POTENTIALS

  2016cites this paper
• High-throughput sequencing-based analysis of endogenetic fungal communities inhabiting the Chinese Cordyceps reveals unexpectedly high fungal diversity

  2016cites this paper
• Hypocriols A-F, Heterodimeric Botryane Ethers from Hypocrea sp., an Insect-Associated Fungus.

  2016cites this paper
• Phylogeny of type I polyketide synthases (PKSs) in fungal entomopathogens and expression analysis of PKS genes in Beauveria bassiana BCC 2660.

  2015cites this paper
• Toward a Cancer Drug of Fungal Origin

  2015cites this paper
• Concise Total Synthesis of (+)-Luteoalbusins A and B.

  2015cites this paper
• Review on Pharmacologically Active Metabolites from Yarsagumba (Ophiocordyceps sinensis), an Epitome of Himalayan Elixir

  2014cites this paper
• Endophytic Fungi: Novel Sources of Anticancer Molecules

  2014cites this paper
• 11′-Deoxyverticillin A (C42) promotes autophagy through K-Ras/GSK3 signaling pathway in HCT116 cells

  2014cites this paper
• Endophytic microbes: A novel source for biologically/pharmacologically active secondary metabolites

  2014cites this paper
• Apoptosis induced by desmethyl-lasiodiplodin is associated with upregulation of apoptotic genes and downregulation of monocyte chemotactic protein-3

  2013cites this paper
• Synthesis and Anticancer Activity of Epipolythiodiketopiperazine Alkaloids.

  2013cites this paper
• High-resolution MS, MS/MS, and UV database of fungal secondary metabolites as a dereplication protocol for bioactive natural products.

  2013cites this paper
• Properties of Cordyceps Sinensis: A review

  2013influential citation
• General approach for preparing epidithiodioxopiperazines from trioxopiperazine precursors: enantioselective total syntheses of (+)- and (-)-gliocladine C, (+)-leptosin D, (+)-T988C, (+)-bionectin A, and (+)-gliocladin A.

  2013cites this paper
• Cordyceps militaris and mycelial fermentation induced apoptosis and autophagy of human glioblastoma cells

  2012cites this paper
• Endophytic fungi from medicinal plants: a treasure hunt for bioactive metabolites

  2012cites this paper
• A spiro[chroman-3,7'-isochromene]-4,6'(8'H)-dione from the Cordyceps-colonizing fungus Fimetariella sp.

  2012cites this paper
• Ophiocordyceps sinensis, the flagship fungus of China: terminology, life strategy and ecology

  2012influential citation
• Biology of Endophytic Fungi

  2012cites this paper
• Cytotoxic epipolythiodioxopiperazine alkaloids from filamentous fungi of the Bionectriaceae

  2012influential citation
• Epipolythiodioxopiperazines from fungi: chemistry and bioactivities.

  2011cites this paper
• Bioactive Compounds from Endophytes and their Potential in Pharmaceutical Effect: A Review

  2011cites this paper
• Two New Imidazolone‐Containing Alkaloids and Further Metabolites from the Ascomycete Fungus Tricladium sp.

  2011cites this paper
• Pro-apoptotic effects of Paecilomyces hepiali, a Cordyceps sinensis extract on human lung adenocarcinoma A549 cells in vitro.

  2011cites this paper
• N-hydroxypyridones, phenylhydrazones, and a quinazolinone from Isaria farinosa.

  2011cites this paper
• Reparative properties of the traditional Chinese medicine Cordyceps sinensis (Chinese caterpillar mushroom) using HT29 cell culture and rat gastric damage models of injury.

  2011cites this paper
• Cordyceps Mushroom: A Potent Anticancer Nutraceutical

  2010cites this paper
• The Use of Endophytes to Obtain Bioactive Compounds and Their Application in Biotransformation Process

  2010cites this paper
• Mycobiotal investigation of natural Ophiocordyceps sinensis based on culture-dependent investigation

  2010cites this paper
• Polyketides from the ascomycete fungus Leptosphaeria sp.

  2010cites this paper