Current Concepts in Diabetic Retinopathy

For the past several decades, tremendous efforts have been made to decrease the complications of diabetes, including diabetic retinopathy. New diagnostic modalities like ultrawide field fundus fluorescein angiography and spectral domain optical coherence tomography has allowed more accurate diagnosis of early diabetic retinopathy and diabetic macular edema. Antivascular endothelial growth factors are now extensively used to treat diabetic retinopathy and macular edema with promising results. There remains uncertainty over the long term effects and the socioeconomic costs of these agents.

• Publication year

  2014

• Venue

  Diabetes & Metabolism Journal

• Publication date

  2014-12-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.4093/dmj.2014.38.6.416PMID 25541604PMCID 4273027
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Body mass index and retinopathy in Asian populations with diabetes mellitus

  2015cited by this paper
• Optical coherence tomography (OCT) for detection of macular oedema in patients with diabetic retinopathy.

  2015cited by this paper
• Body mass index and retinopathy in Asian populations with diabetes mellitus

  2015cited by this paper
• SAVE: a grading protocol for clinically significant diabetic macular oedema based on optical coherence tomography and fluorescein angiography

  2014cited by this paper
• Intravitreal aflibercept for diabetic macular edema.

  2014cited by this paper
• Challenges in elucidating the genetics of diabetic retinopathy.

  2014cited by this paper
• Long-term outcomes of ranibizumab therapy for diabetic macular edema: the 36-month results from two phase III trials: RISE and RIDE.

  2013cited by this paper
• Structural Changes in Individual Retinal Layers in Diabetic Macular Edema

  2013cited by this paper
• Genome-wide association study in a Chinese population with diabetic retinopathy.

  2013cited by this paper
• Body Mass Index: A Risk Factor for Retinopathy in Type 2 Diabetic Patients

  2013cited by this paper
• Fruit Intake and Incident Diabetic Retinopathy with Type 2 Diabetes

  2013cited by this paper
• Is the prevalence of visual impairment rising or falling in the people with diabetes mellitus? It depends on who you study.

  2013cited by this paper
• ULTRA–WIDE-FIELD ANGIOGRAPHY IMPROVES THE DETECTION AND CLASSIFICATION OF DIABETIC RETINOPATHY

  2012cited by this paper
• Sustained delivery fluocinolone acetonide vitreous inserts provide benefit for at least 3 years in patients with diabetic macular edema.

  2012cited by this paper
• Ranibizumab for diabetic macular edema: results from 2 phase III randomized trials: RISE and RIDE.

  2012cited by this paper
• Prevalence of nonrefractive visual impairment in US adults and associated risk factors, 1999-2002 and 2005-2008.

  2012cited by this paper
• Global Prevalence and Major Risk Factors of Diabetic Retinopathy

  2012cited by this paper
• Segmentational analysis of retinal thickness after vitrectomy in diabetic macular edema.

  2012cited by this paper
• The RESTORE study: ranibizumab monotherapy or combined with laser versus laser monotherapy for diabetic macular edema.

  2011cited by this paper
• Outcomes and Complications of 25-Gauge Transconjunctival Sutureless Vitrectomy for Proliferative Diabetic Retinopathy

  2011cited by this paper
• Prevalence of and risk factors for diabetic retinopathy in Koreans with type II diabetes: baseline characteristics of Seoul Metropolitan City-Diabetes Prevention Program (SMC-DPP) participants

  2011cited by this paper
• Optical coherence tomography (OCT) for detection of macular oedema in patients with diabetic retinopathy.

  2011cited by this paper
• The DA VINCI Study: phase 2 primary results of VEGF Trap-Eye in patients with diabetic macular edema.

  2011cited by this paper
• Are obesity and anthropometry risk factors for diabetic retinopathy? The diabetes management project.

  2011cited by this paper
• Outcomes of 25-gauge vitrectomy for proliferative diabetic retinopathy

  2011cited by this paper
• Long-term benefit of sustained-delivery fluocinolone acetonide vitreous inserts for diabetic macular edema.

  2011cited by this paper
• Genome-wide association study of diabetic retinopathy in a Taiwanese population.

  2011cited by this paper
• Prevalence of diabetic retinopathy in the United States, 2005-2008.

  2010influential reference
• Are Individuals With Diabetes Seeing Better?

  2010influential reference
• Safety and Efficacy of Ranibizumab in Diabetic Macular Edema (RESOLVE Study)

  2010cited by this paper
• Impact of comorbid conditions and race/ethnicity on glycemic control among the US population with type 2 diabetes, 1988-1994 to 1999-2004.

  2010cited by this paper
• A prospective randomized trial of intravitreal bevacizumab or laser therapy in the management of diabetic macular edema (BOLT study) 12-month data: report 2.

  2010cited by this paper
• Diabetic retinopathy

  2010cited by this paper
• COMPARISON OF CLINICAL OUTCOMES BETWEEN 23-GAUGE AND 20-GAUGE VITRECTOMY IN PATIENTS WITH PROLIFERATIVE DIABETIC RETINOPATHY

  2010cited by this paper
• The 25-year incidence of visual impairment in type 1 diabetes mellitus the wisconsin epidemiologic study of diabetic retinopathy.

  2010cited by this paper
• The Wisconsin Epidemiologic Study of Diabetic Retinopathy XXIII: the twenty-five-year incidence of macular edema in persons with type 1 diabetes.

  2009cited by this paper
• Changes in visual impairment prevalence by period of diagnosis of diabetes: the Wisconsin Epidemiologic Study of Diabetic Retinopathy.

  2009cited by this paper
• Trends in medication use among US adults with diabetes mellitus: glycemic control at the expense of controlling cardiovascular risk factors.

  2009cited by this paper
• Prevalence and Management of Diabetes in Korean Adults

  2009cited by this paper
• Diabetes prevalence and therapeutic target achievement in the United States, 1999 to 2006.

  2009cited by this paper
• Ultrawide Angle Angiography for the Detection and Management of Diabetic Retinopathy

  2009cited by this paper
• A systematic correlation of angiography and high-resolution optical coherence tomography in diabetic macular edema.

  2009cited by this paper
• Optical coherence tomographic hyperreflective foci: a morphologic sign of lipid extravasation in diabetic macular edema.

  2009cited by this paper
• A randomized trial comparing intravitreal triamcinolone acetonide and focal/grid photocoagulation for diabetic macular edema.

  2008cited by this paper
• Prevalence, treatment, and control of diagnosed diabetes in the U.S. National Health and Nutrition Examination Survey 1999-2004.

  2008cited by this paper
• The Wisconsin Epidemiologic Study of Diabetic Retinopathy: XXII the twenty-five-year progression of retinopathy in persons with type 1 diabetes.

  2008cited by this paper
• Temporal trends in the age-specific prevalence of diabetes and diabetic retinopathy in older persons: Population-based survey findings.

  2006cited by this paper
• A Community-Based Epidemiologic Study of Gender Differences in the Relationship between Insulin Resistance/β-Cell Dysfunction and Diabetic Retinopathy among Type 2 Diabetic Patients in Kinmen, Taiwan

  2006cited by this paper
• Effects of High Fruit-Vegetable and/or Low-Fat Intervention on Plasma Micronutrient Levels

  2006cited by this paper
• Ultra-wide-field fluorescein angiography of the ocular fundus.

  2005cited by this paper
• Declining incidence of severe retinopathy and persisting decrease of nephropathy in an unselected population of Type 1 diabetes—the Linköping Diabetes Complications Study

  2004cited by this paper
• Non-mydriatic panoramic fundus imaging using a non-contact scanning laser-based system.

  2003cited by this paper
• Decreasing incidence of severe diabetic microangiopathy in type 1 diabetes.

  2003cited by this paper
• The Prevalence of Diabetic Retinopathy in the United States

  2002cited by this paper
• [Diabetic retinopathy].

  2001cited by this paper
• Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group.

  1999cited by this paper
• Development and Progression of Diabetic Retinopathy in Koreans With NIDDM

  1998cited by this paper
• Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group.

  1998cited by this paper
• Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)

  1998cited by this paper
• Is obesity related to microvascular and macrovascular complications in diabetes? The Wisconsin Epidemiologic Study of Diabetic Retinopathy.

  1997cited by this paper
• Older-onset diabetes and lens opacities. The Beaver Dam Eye Study.

  1995cited by this paper
• Open-angle glaucoma and older-onset diabetes. The Beaver Dam Eye Study.

  1994cited by this paper
• High prevalence of proliferative retinopathy in diabetic patients with low pancreatic B-cell capacity.

  1989cited by this paper
• Insulin Resistance and Insulin Deficiency in Diabetic Retinopathy of Non-insulin-dependent Diabetes

  1983cited by this paper

• Old Target with New Vision: In Search of New Therapeutics for Diabetic Retinopathy by Selective Modulation of Aldose Reductase

  2026cites this paper
• Associations of serum uric acid to eGFR ratio with diabetic retinopathy in individuals with type 2 diabetes

  2025cites this paper
• Nonlinear relationship between diabetes mellitus duration and diabetic retinopathy

  2024cites this paper
• Ocular microvascular alteration in patients with myocardial infarction—a new OCTA study

  2024cites this paper
• Aldose Reductase as a Key Target in the Prevention and Treatment of Diabetic Retinopathy: A Comprehensive Review

  2024cites this paper
• Correlation Between Thyroid-Related Hormones and Diabetic Retinopathy in Type 2 Diabetes Mellitus Patients with Normal Thyroid Function: A Retrospective Study

  2024cites this paper
• Novel risk score model for non-proliferative diabetic retinopathy based on untargeted metabolomics of venous blood

  2023cites this paper
• Effect of retinol and α-tocopherol supplementation on photoreceptor and retinal ganglion cell apoptosis in diabetic rats model

  2022cites this paper
• Diabetic retinopathy risk prediction in patients with type 2 diabetes mellitus using a nomogram model

  2022cites this paper
• Diabetic Retinopathy: An Overview on Mechanisms, Pathophysiology and Pharmacotherapy

  2022cites this paper
• Dysbiosis in the Gut Microbiome in Streptozotocin-Induced Diabetes Rats and Follow-Up During Retinal Changes

  2021cites this paper
• Dietary glutamic acid and aspartic acid as biomarkers for predicting diabetic retinopathy

  2021cites this paper
• Importance of medication adherence in treatment needed diabetic retinopathy

  2021cites this paper
• Targeting Netrin-1 and -4 as a Novel Diagnostic Parameter and Treatment Option for Diabetic Retinopathy

  2020cites this paper
• Lipoprotein(a) and Apolipoproteins as Predictors for Diabetic Retinopathy and Its Severity in Adults With Type 2 Diabetes: A Case-Cohort Study.

  2020cites this paper
• Microfluidic Immunosensor for Point-of-Care-Testing of Beta-2-Microglobulin in Tear

  2020cites this paper
• Plasma amino acids and oxylipins as potential multi-biomarkers for predicting diabetic macular edema

  2020cites this paper
• Association between neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and diabetic retinopathy among diabetic patients without a related family history

  2020cites this paper
• Hyperglycemia Induces Neutrophil Extracellular Traps Formation Through an NADPH Oxidase-Dependent Pathway in Diabetic Retinopathy

  2019cites this paper
• Correlations of blood lipids with early changes in macular thickness in patients with diabetes.

  2019cites this paper
• Evaluation of microvascular changes in the perifoveal vascular network using optical coherence tomography angiography (OCTA) in type I diabetes mellitus: a large scale prospective trial

  2019cites this paper
• Plasma glutamine and glutamic acid are potential biomarkers for predicting diabetic retinopathy

  2018cites this paper
• The relationship of dietary fish intake to diabetic retinopathy and retinal vascular caliber in patients with type 2 diabetes

  2018cites this paper
• Intravitreal pro-inflammatory cytokines in non-obese diabetic mice: Modelling signs of diabetic retinopathy

  2018cites this paper
• Foveal avascular zone area and parafoveal vessel density measurements in different stages of diabetic retinopathy by optical coherence tomography angiography.

  2017cites this paper
• Correlation Analysis between Foveal Avascular Zone and Peripheral Ischemic Index in Diabetic Retinopathy: A Pilot Study.

  2017cites this paper
• Letter: Features of Long-Standing Korean Type 2 Diabetes Mellitus Patients with Diabetic Retinopathy: A Study Based on Standardized Clinical Data (Diabetes Metab J 2017;41:393-404)

  2017cites this paper
• Clinical Characteristics of Patients with Newly Diagnosed Diabetic Macular Edema in Turkey: A Real-Life Registry Study—TURK-DEM

  2017cites this paper
• Association of CYP 4 A 11 gene polymorphism with diabetic retinopathy in Chinese patients

  2016cites this paper
• [Update of diabetic retinopathy for Primary Care physicians: Towards an improvement of telematic medicine].

  2016cites this paper
• Current Challenges in Diabetic Retinopathy: Are We Really Doing Better?

  2016cites this paper
• Targeting VEGF in eye neovascularization: What's new?: A comprehensive review on current therapies and oligonucleotide-based interventions under development.

  2016cites this paper
• Estimating the proportion of persons with diabetes developing diabetic retinopathy in India: A systematic review and meta-analysis

  2016cites this paper
• Lipoprotein(a) predicts the development of diabetic retinopathy in people with type 2 diabetes mellitus.

  2016cites this paper
• Association between LEKR1‐CCNL1 and IGSF21‐KLHDC7A gene polymorphisms and diabetic retinopathy of type 2 diabetes mellitus in the Chinese Han population

  2016cites this paper
• Nanosystems based on siRNA silencing HuR expression counteract diabetic retinopathy in rat.

  2016cites this paper
• What have we learnt about the management of diabetic macular edema in the antivascular endothelial growth factor and corticosteroid era?

  2015cites this paper
• Potential New Modes of Treatment of Neurotrophic Keratopathy

  2015cites this paper
• Nanoengineering of therapeutics for retinal vascular disease.

  2015cites this paper
• Recent developments in ocular drug delivery*

  2015cites this paper
• Functional outcome of macular edema in different retinal disorders.

  2015cites this paper
• Anatomical effects of dexamethasone intravitreal implant in diabetic macular oedema: a pooled analysis of 3-year phase III trials

  2015cites this paper