The nucleus is an intracellular propagator of tensile forces in NIH 3T3 fibroblasts

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Journal of Cell Science

• Publication date

  2015-05-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/jcs.161703PMID 25908852PMCID PMC4457156
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Actomyosin pulls to advance the nucleus in a migrating tissue cell.

  2014cited by this paper
• Generation of compartmentalized pressure by a nuclear piston governs cell motility in a 3D matrix

  2014cited by this paper
• Tight coupling between nucleus and cell migration through the perinuclear actin cap

  2014cited by this paper
• Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

  2013influential reference
• Nuclear positioning.

  2013cited by this paper
• Modulation of Nuclear Shape by Substrate Rigidity

  2013influential reference
• Mechanobiology and developmental control.

  2013cited by this paper
• Emerin organizes actin flow for nuclear movement and centrosome orientation in migrating fibroblasts

  2013cited by this paper
• Growing Microtubules Push the Oocyte Nucleus to Polarize the Drosophila Dorsal-Ventral Axis

  2012cited by this paper
• Opposing microtubule motors drive robust nuclear dynamics in developing muscle cells

  2012cited by this paper
• Spatial coordination between cell and nuclear shape within micropatterned endothelial cells

  2012cited by this paper
• Nuclear positioning: mechanisms and functions.

  2011cited by this paper
• How dynein and microtubules rotate the nucleus

  2011cited by this paper
• Orientation and function of the nuclear-centrosomal axis during cell migration.

  2011influential reference
• Nuclear mechanics during cell migration.

  2011influential reference
• Nesprin-3 augments peripheral nuclear localization of intermediate filaments in zebrafish

  2011cited by this paper
• Influence of cell geometry on division-plane positioning.

  2011cited by this paper
• Cytoplasmic intermediate filaments mediate actin-driven positioning of the nucleus

  2011cited by this paper
• Lamin A variants that cause striated muscle disease are defective in anchoring transmembrane actin-associated nuclear lines for nuclear movement

  2010cited by this paper
• Mechanical tugging force regulates the size of cell–cell junctions

  2010cited by this paper
• Light-mediated activation reveals a key role for Rac in collective guidance of cell movement in vivo

  2010cited by this paper
• Linear Arrays of Nuclear Envelope Proteins Harness Retrograde Actin Flow for Nuclear Movement

  2010cited by this paper
• Kinesin-1 and dynein at the nuclear envelope mediate the bidirectional migrations of nuclei

  2010cited by this paper
• UNC-83 coordinates kinesin-1 and dynein activities at the nuclear envelope during nuclear migration.

  2010cited by this paper
• Actomyosin tension exerted on the nucleus through nesprin-1 connections influences endothelial cell adhesion, migration, and cyclic strain-induced reorientation.

  2010cited by this paper
• UNC-83 is a nuclear-specific cargo adaptor for kinesin-1-mediated nuclear migration

  2009cited by this paper
• Coordination of Rho GTPase activities during cell protrusion

  2009cited by this paper
• A genetically-encoded photoactivatable Rac controls the motility of living cells

  2009cited by this paper
• Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus

  2009cited by this paper
• Cell polarity triggered by cell-cell adhesion via E-cadherin

  2009cited by this paper
• Nuclei take a position: managing nuclear location.

  2009cited by this paper
• Nesprin 4 is an outer nuclear membrane protein that can induce kinesin-mediated cell polarization

  2009cited by this paper
• Dynein drives nuclear rotation during forward progression of motile fibroblasts

  2008cited by this paper
• Mechanisms of asymmetric cell division: flies and worms pave the way

  2008cited by this paper
• Communication between the cytoskeleton and the nuclear envelope to position the nucleus.

  2007cited by this paper
• Requirements for the localization of nesprin-3 at the nuclear envelope and its interaction with plectin

  2007cited by this paper
• Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation

  2007cited by this paper
• Mechanical forces alter zyxin unbinding kinetics within focal adhesions of living cells

  2006cited by this paper
• Nuclear movement regulated by Cdc42, MRCK, myosin, and actin flow establishes MTOC polarization in migrating cells.

  2005influential reference
• UvA-DARE ( Digital Academic Repository ) Plectin ' s actin-binding domain : a versatile element Litjens

  2005cited by this paper
• Traction force microscopy of migrating normal and H-ras transformed 3T3 fibroblasts.

  2001cited by this paper
• Cell movement is guided by the rigidity of the substrate.

  2000cited by this paper
• Stresses at the cell-to-substrate interface during locomotion of fibroblasts.

  1999cited by this paper
• Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure.

  1997cited by this paper
• cornichon and the EGF receptor signaling process are necessary for both anterior-posterior and dorsal-ventral pattern formation in Drosophila.

  1995cited by this paper
• Altering the cellular mechanical force balance results in integrated changes in cell, cytoskeletal and nuclear shape.

  1992cited by this paper

• Nuclear mechanobiology in confined cell migration

  2026influential citation
• Cellular and Nuclear Forces: An Overview.

  2025cites this paper
• Evidence for Drop-Like Nuclear Deformation in Sheared Endothelial Monolayers.

  2025cites this paper
• Immune Cell Migration Models Synergize Nuclear Piston, Uropod, and Microenvironment into Hydraulic Cell Engine

  2025cites this paper
• Fabrication of a PDMS-based substrate with a stiffness gradient for modeling the mechanical microenvironment in single and collective cell studies

  2025cites this paper
• Mechanical network motifs as targets for mechanomedicine.

  2024cites this paper
• Advances in mechanotransduction and sonobiology: effects of audible acoustic waves and low-vibration stimulations on mammalian cells

  2024cites this paper
• The Plasma Membrane and Mechanoregulation in Cells

  2024cites this paper
• Nucleocytoplasmic transport rates are regulated by cellular processes that modulate GTP availability

  2024cites this paper
• Responses of osteoblasts under varied tensile stress types induced by stretching basement materials

  2024cites this paper
• The crystal structure of SUN1-KASH6 reveals an asymmetric LINC complex architecture compatible with nuclear membrane insertion

  2024cites this paper
• Molecular dynamics model of mechanophore sensors for biological force measurement

  2024cites this paper
• Compressive forces stabilize microtubules in living cells

  2023cites this paper
• Mechanotherapy in Oncology: Targeting Nuclear Mechanics and Mechanotransduction.

  2023cites this paper
• Molecular insights into LINC complex architecture through the crystal structure of a luminal trimeric coiled-coil domain of SUN1

  2023cites this paper
• Crystal structure of SUN1-KASH6 reveals an asymmetric LINC complex architecture compatible with nuclear membrane insertion

  2023cites this paper
• Inner Nuclear Membrane Protein, SUN1, is Required for Cytoskeletal Force Generation and Focal Adhesion Maturation

  2022cites this paper
• Actin contraction controls nuclear blebbing and rupture independent of actin confinement

  2022cites this paper
• Mechanosensing in macrophages and dendritic cells in steady-state and disease

  2022cites this paper
• The LINC Complex Assists the Nuclear Import of Mechanosensitive Transcriptional Regulators.

  2022cites this paper
• Mechanics and functional consequences of nuclear deformations

  2022cites this paper
• The Elephant in the Cell: Nuclear Mechanics and Mechanobiology.

  2022cites this paper
• Viscous shaping of the compliant cell nucleus

  2022cites this paper
• Cell stretchers and the LINC complex in mechanotransduction.

  2021cites this paper
• A mesoscale mechanical model of cellular interactions.

  2021cites this paper
• Sculpting Rupture‐Free Nuclear Shapes in Fibrous Environments

  2021cites this paper
• Cytoskeletal control of early mammalian development

  2021cites this paper
• A single stiffened nucleus alters cell dynamics and coherence in a monolayer

  2021cites this paper
• Changes in Nuclear Shape and Gene Expression in Response to Simulated Microgravity Are LINC Complex-Dependent

  2020cites this paper
• The CAR T‐Cell Mechanoimmunology at a Glance

  2020cites this paper
• Alterations in cellular force parameters and cell projections in Nasal polyps-derived fibroblasts.

  2020cites this paper
• The osmotic demyelination syndrome: the resilience of thalamic neurons is verified with transmission electron microscopy

  2020cites this paper
• A molecular mechanism for LINC complex branching by structurally diverse SUN-KASH 6:6 assemblies

  2020cites this paper
• Lamin microaggregates lead to altered mechanotransmission in progerin-expressing cells

  2020cites this paper
• The matrix environmental and cell mechanical properties regulate cell migration and contribute to the invasive phenotype of cancer cells

  2019cites this paper
• Local, transient tensile stress on the nuclear membrane causes membrane rupture

  2019cites this paper
• Apical cell protrusions cause vertical deformation of the soft cancer nucleus

  2019cites this paper
• Design of biomimetic collagen matrices by reagent-free electron beam induced crosslinking: Structure-property relationships and cellular response

  2019cites this paper
• Feeling the force : role of AmotL2 in normal development and cancer

  2019cites this paper
• Mechanical Function of the Nucleus in Force Generation during Epithelial Morphogenesis

  2019cites this paper
• Single Cell Imaging of Nuclear Architecture Changes

  2019cites this paper
• Mechanical Stabilization of the Glandular Acinus by Linker of Nucleoskeleton and Cytoskeleton Complex.

  2019cites this paper
• Fascin regulates protrusions and delamination to mediate invasive, collective cell migration in vivo

  2019cites this paper
• The Interplay Between Cell-Cell and Cell-Matrix Forces Regulates Cell Migration Dynamics.

  2019cites this paper
• Lamin A/C Cardiomyopathy: Implications for Treatment

  2019cites this paper
• Biophysical properties of intermediate states of EMT outperform both epithelial and mesenchymal states

  2019cites this paper
• Microscale Interrogation of 3D Tissue Mechanics

  2019cites this paper
• Transient Nuclear Envelope Rupture during Cell Migration: A Cause of Genomic Instability and a Novel Opportunity for Therapeutic Intervention

  2018cites this paper
• Mechanical principles of nuclear shaping and positioning

  2018influential citation
• Direct Force Probe for Nuclear Mechanics.

  2018cites this paper
• Cellular and Nuclear Forces: An Overview.

  2018cites this paper
• Cyclic Uniaxial Tensile Strain Enhances the Mechanical Properties of Engineered, Scaffold-Free Tendon Fibers

  2018cites this paper
• cells reveal differential roles of the nucleus in cell migration, polarity, and mechanotransduction

  2018cites this paper
• Role of the Nucleus as a Sensor of Cell Environment Topography

  2018cites this paper
• Mechanosensing by the Nuclear Lamina: From Embryonic Development to Aging

  2018cites this paper
• Nuclear Rupture in Progeria Expressing Cells

  2018cites this paper
• Determining mechanical features of modulated epithelial monolayers using subnuclear particle tracking

  2018influential citation
• Enucleated cells reveal differential roles of the nucleus in cell migration, polarity, and mechanotransduction

  2018cites this paper
• Emerging views of the nucleus as a cellular mechanosensor

  2018cites this paper
• The Neutrophil Nucleus: An Important Influence on Neutrophil Migration and Function

  2018influential citation
• Oxidative Stress Alters the Morphological Responses of Myoblasts to Single-Site Membrane Photoporation

  2017cites this paper
• Coordinated increase of nuclear tension and lamin-A with matrix stiffness outcompetes lamin-B receptor that favors soft tissue phenotypes

  2017cites this paper
• Mechanosensing by the nucleus: From pathways to scaling relationships

  2017cites this paper
• Inside the Cell: Integrins as New Governors of Nuclear Alterations?

  2017cites this paper
• Nuclear positioning in migrating fibroblasts.

  2017cites this paper
• Mechanotransduction via the nuclear envelope: a distant reflection of the cell surface.

  2017influential citation
• Distinct Nuclear-Cytoskeletal LINCages Position the Nucleus for Homeostasis, Polarization and Migration

  2017cites this paper
• An Unresolved LINC in the Nuclear Envelope

  2016cites this paper
• An Unresolved LINC in the Nuclear Envelope

  2016cites this paper
• Nesprin-2G, a Component of the Nuclear LINC Complex, Is Subject to Myosin-Dependent Tension.

  2016cites this paper
• Mechanobiology of Chromatin and the Nuclear Interior

  2016cites this paper
• New approaches for understanding the nuclear force balance in living, adherent cells.

  2016cites this paper
• Cross talk between the cytoplasm and nucleus during development and disease.

  2016cites this paper
• Increased nuclear stiffness via FAK-ERK1/2 signaling is necessary for synthetic mechano-growth factor E peptide-induced tenocyte migration

  2016cites this paper
• Fascin Regulates Nuclear Movement and Deformation in Migrating Cells

  2016influential citation
• The mammalian LINC complex regulates genome transcriptional responses to substrate rigidity

  2016cites this paper
• Vertical uniformity of cells and nuclei in epithelial monolayers

  2016cites this paper
• Dynamic, mechanical integration between nucleus and cell- where physics meets biology

  2015cites this paper
• Moving Cell Boundaries Drive Nuclear Shaping during Cell Spreading.

  2015cites this paper
• Cancer cell migration in 3D tissue: Negotiating space by proteolysis and nuclear deformability

  2015cites this paper
• Enucleated Cells Reveal Differential Roles of the Nucleus in Cell Enucleated Cells Reveal Differential Roles of the Nucleus in Cell Migration, Polarity, and Mechanotransduction Migration, Polarity, and Mechanotransduction

  year unknowncites this paper