Naturally Occurring Disk Herniation in Dogs: An Opportunity for Pre-Clinical Spinal Cord Injury Research

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Journal of Neurotrauma

• Publication date

  2011-04-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1089/neu.2010.1645PMID 21438715PMCID PMC3070145
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A Grading System To Evaluate Objectively the Strength of Pre-Clinical Data of Acute Neuroprotective Therapies for Clinical Translation in Spinal Cord Injury

  2011cited by this paper
• Cerebrospinal fluid myelin basic protein as a prognostic biomarker in dogs with thoracolumbar intervertebral disk herniation.

  2010cited by this paper
• Predictors of Early Mortality After Traumatic Spinal Cord Injury: A Population-Based Study

  2010influential reference
• A bilateral cervical contusion injury model in mice: assessment of gripping strength as a measure of forelimb motor function.

  2010cited by this paper
• Lesion growth and degeneration patterns measured using diffusion tensor 9.4-T magnetic resonance imaging in rat spinal cord injury.

  2010cited by this paper
• Cartilage Oligomeric Matrix Protein in Canine Spinal Cord Appears in the Cerebrospinal Fluid Associated With Intervertebral Disc Herniation

  2010cited by this paper
• Canine Thoracolumbar Intervertebral Disk Disease : Diagnosis , Prognosis , and Treatment *

  2009cited by this paper
• Magnetic resonance imaging in dogs with neurologic impairment due to acute thoracic and lumbar intervertebral disk herniation.

  2009influential reference
• Description and repeatability of a newly developed spinal cord injury scale for dogs.

  2009influential reference
• Accuracy of Spatiotemporal Variables in Gait Analysis of Neurologic Dogs

  2009cited by this paper
• Canine thoracolumbar invertebral disk disease: diagnosis, prognosis, and treatment.

  2009cited by this paper
• ASIA impairment scale conversion in traumatic SCI: is it related with the ability to walk? A descriptive comparison with functional ambulation outcome measures in 273 patients

  2009cited by this paper
• Magnesium Chloride in a Polyethylene Glycol Formulation as a Neuroprotective Therapy for Acute Spinal Cord Injury: Preclinical Refinement and Optimization

  2009cited by this paper
• Owner-perceived, weighted quality-of-life assessments in dogs with spinal cord injuries.

  2008cited by this paper
• Matrix metalloproteinase-9/gelatinase B is a putative therapeutic target of chronic obstructive pulmonary disease and multiple sclerosis.

  2008cited by this paper
• Repair and Neurorehabilitation Strategies for Spinal Cord Injury

  2008cited by this paper
• Randomized, Blinded, Placebo-Controlled Clinical Trial of N-Acetylcysteine in Dogs With Spinal Cord Trauma From Acute Intervertebral Disc Disease

  2008influential reference
• A re-assessment of the effects of a Nogo-66 receptor antagonist on regenerative growth of axons and locomotor recovery after spinal cord injury in mice.

  2008cited by this paper
• Deviations in gait pattern in experimental models of hindlimb paresis shown by a novel pressure mapping system

  2007cited by this paper
• Assessing the burden of injury in six European countries.

  2007cited by this paper
• Update on the treatment of spinal cord injury.

  2007cited by this paper
• Effects of polyethylene glycol and magnesium sulfate administration on clinically relevant neurological outcomes after spinal cord injury in the rat

  2007cited by this paper
• Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: clinical trial design

  2007cited by this paper
• Development of a universal measure of quadrupedal forelimb-hindlimb coordination using digital motion capture and computerised analysis

  2007influential reference
• Curiosity and cure: Translational research strategies for neural repair‐mediated rehabilitation

  2007cited by this paper
• Phase 2 trial of sustained-release fampridine in chronic spinal cord injury

  2007cited by this paper
• Acute cervical traumatic spinal cord injury: MR imaging findings correlated with neurologic outcome--prospective study with 100 consecutive patients.

  2007cited by this paper
• REVIEW OF TREATMENT TRIALS IN HUMANSPINAL CORD INJURY: ISSUES, DIFFICULTIES, AND RECOMMENDATIONS

  2006cited by this paper
• Concentrations of 15F2t isoprostane in urine of dogs with intervertebral disk disease.

  2006cited by this paper
• Clinical canine spinal cord injury provides an opportunity to examine the issues in translating laboratory techniques into practical therapy

  2006influential reference
• Magnetic resonance imaging findings in dogs with thoracolumbar intervertebral disk disease: 69 cases (1997-2005).

  2006cited by this paper
• Isoflurane Produces Delayed Preconditioning against Spinal Cord Ischemic Injury via Release of Free Radicals in Rabbits

  2006cited by this paper
• Outcome and prognostic factors in nonambulatory Hansen Type I intervertebral disc extrusions: 308 cases

  2006cited by this paper
• Matrix metalloproteinase-9 activity in the cerebrospinal fluid and serum of dogs with acute spinal cord trauma from intervertebral disk disease.

  2006cited by this paper
• Notochordal Cell Produce and Assemble Extracellular Matrix in a Distinct Manner, Which May Be Responsible for the Maintenance of Healthy Nucleus Pulposus

  2006cited by this paper
• Histological and Ultrastructural Analysis of White Matter Damage after Naturally‐occurring Spinal Cord Injury

  2006influential reference
• Identification of Inflicted Traumatic Brain Injury in Well-Appearing Infants Using Serum and Cerebrospinal Markers: A Possible Screening Tool

  2006cited by this paper
• Prognostic value of magnetic resonance imaging in dogs with paraplegia caused by thoracolumbar intervertebral disk extrusion: 77 cases (2000-2003).

  2005cited by this paper
• Thoracolumbar disc extrusion associated with extensive epidural haemorrhage: a retrospective study of 23 dogs.

  2005cited by this paper
• Oscillating field stimulation for complete spinal cord injury in humans: a phase 1 trial.

  2005cited by this paper
• Isoflurane preconditioning protects motor neurons from spinal cord ischemia: its dose-response effects and activation of mitochondrial adenosine triphosphate-dependent potassium channel.

  2005cited by this paper
• Spinal shock--comparative aspects and clinical relevance.

  2005cited by this paper
• Rehabilitation for the neurologic patient.

  2005cited by this paper
• Autologous Olfactory Glial Cell Transplantation Is Reliable and Safe in Naturally Occurring Canine Spinal Cord Injury

  2005cited by this paper
• The Functional Significance of Cell Clusters in the Notochordal Nucleus Pulposus: Survival and Signaling in the Canine Intervertebral Disc

  2004cited by this paper
• Recovery of Pelvic Limb Function in Dogs following Acute Intervertebral Disc Herniations

  2004cited by this paper
• A Preliminary Study of Intravenous Surfactants in Paraplegic Dogs: Polymer Therapy in Canine Clinical SCI

  2004cited by this paper
• The Pathology of Human Spinal Cord Injury: Defining the Problems

  2004influential reference
• Effect of 4-aminopyridine on gait in ambulatory spinal cord injuries: a double-blind, placebo-controlled, crossover trial

  2004cited by this paper
• Transplanted Olfactory Ensheathing Cells Promote Regeneration of Cut Adult Rat Optic Nerve Axons

  2003cited by this paper
• Transplantation of Olfactory Ensheathing Cells into Spinal Cord Lesions Restores Breathing and Climbing

  2003cited by this paper
• Long-term functional outcome of dogs with severe injuries of the thoracolumbar spinal cord: 87 cases (1996-2001).

  2003influential reference
• Functional Repair of the Corticospinal Tract by Delayed Transplantation of Olfactory Ensheathing Cells in Adult Rats

  2003cited by this paper
• Neuroprotective Effect of N-Acetylcysteine and Hypothermia on the Spinal Cord Ischemia—Reperfusion Injury

  2003influential reference
• Intramedullary spinal cord damage associated with intervertebral disk material in a dog.

  2002cited by this paper
• Radiographic diagnosis: intramedullary extrusion of an intervertebral disc.

  2002cited by this paper
• Behavioral recovery from spinal cord injury following delayed application of polyethylene glycol.

  2002cited by this paper
• Three-dimensional morphometry of spinal cord injury following polyethylene glycol treatment.

  2002cited by this paper
• Thoracolumbar disc disease in 71 paraplegic dogs: influence of rate of onset and duration of clinical signs on treatment results.

  2002cited by this paper
• Prognostic indicators for time to ambulation after surgical decompression in nonambulatory dogs with acute thoracolumbar disk extrusions: 112 cases.

  2002cited by this paper
• Matrix Metalloproteinases Limit Functional Recovery after Spinal Cord Injury by Modulation of Early Vascular Events

  2002cited by this paper
• Development of a functional scoring system in dogs with acute spinal cord injuries.

  2001cited by this paper
• Complications of Methylprednisolone Sodium Succinate Therapy in Dachshunds with Surgically Treated Intervertebral Disc Disease

  2001cited by this paper
• Cellular Engineering: Molecular Repair of Membranes to Rescue Cells of the Damaged Nervous System

  2001cited by this paper
• Inheritance of disc calcification in the dachshund.

  2000influential reference
• Immediate recovery from spinal cord injury through molecular repair of nerve membranes with polyethylene glycol

  2000cited by this paper
• CLINICAL ASPECTS OF SURGICAL TREATMENT OF THORACOLUMBAR DISC DISEASE IN DOGS. A RETROSPECTIVE STUDY OF 300 CASES.

  1999cited by this paper
• A review of the neuropathology of human spinal cord injury with emphasis on special features.

  1999cited by this paper
• Laminectomy for 34 dogs with thoracolumbar intervertebral disc disease and loss of deep pain perception.

  1999cited by this paper
• An Imposed Oscillating Electrical Field Improves the Recovery of Function in Neurologically Complete Paraplegic Dogs

  1999influential reference
• Genetic approaches to neurotrauma research: opportunities and potential pitfalls of murine models.

  1999cited by this paper
• Current concepts in the management of acute spinal cord injury.

  1999cited by this paper
• Randomized Double-Blind Crossover Trial of Fampridine-SR (Sustained Release 4-Aminopyridine) in Patients With Incomplete Spinal Cord Injury

  1998cited by this paper
• Matrix metalloproteinase-9 (gelatinase B) is selectively elevated in CSF during relapses and stable phases of multiple sclerosis.

  1998cited by this paper
• Study of spinal cord evoked injury potential by use of computer modeling and in dogs with naturally acquired thoracolumbar spinal cord compression.

  1998cited by this paper
• Clinical and magnetic resonance imaging correlation in acute spinal cord injury

  1997cited by this paper
• Injuries to the central nervous system.

  1996influential reference
• Spinal cord swelling as a myelographic indicator of prognosis: a retrospective study in dogs with intervertebral disc disease and loss of deep pain perception.

  1996cited by this paper
• A Sensitive and Reliable Locomotor Rating Scale for Open Field Testing in Rats

  1995cited by this paper
• Effects of applied electric fields on clinical cases of complete paraplegia in dogs

  1993cited by this paper
• The Effects of 4-Aminopyridine on Neurological Deficits in Chronic Cases of Traumatic Spinal Cord Injury in Dogs: A Phase I Clinical Trial

  1991cited by this paper
• Effect of 4-aminopyridine on axonal conduction-block in chronic spinal cord injury.

  1989cited by this paper
• Correlative analyses of lesion development and functional status after graded spinal cord contusive injuries in the rat.

  1989cited by this paper
• Augmentation by 4-aminopyridine of vestibulospinal free fall responses in chronic spinal-injured cats.

  1987cited by this paper
• Spinal-evoked potentials in dogs with acute compressive thoracolumbar spinal cord disease.

  1987influential reference
• Morphometric analysis of experimental spinal cord injury in the cat: the relation of injury intensity to survival of myelinated axons.

  1986cited by this paper
• Measurement of myelin basic protein by radioimmunoassay in closed head trauma, multiple sclerosis and other neurological diseases.

  1985cited by this paper
• Cellular morphology of chronic spinal cord injury in the cat: analysis of myelinated axons by line-sampling.

  1983cited by this paper
• Patterns of occurrence of disk disease among registered dachshunds.

  1982cited by this paper
• The variation of the glycosaminoglycans of the canine intervertebral disc with ageing. I. Chondrodystrophoid breed.

  1977cited by this paper
• Canine intervertebral disc disease — Occurrence by age, breed, and sex among 8,117 cases

  1976influential reference
• Experimental cervical myelopathy. Effects of ischemia and compression of the canine cervical spinal cord.

  1975cited by this paper
• Incidence of clinical disc disease in the dog

  1975influential reference
• Experimental cervical myelopathy. 3. The canine corticospinal tract. Anatomy and function.

  1973cited by this paper
• Some aspects of the pathology and pathogenesis of the myelopathy caused by disc protrusions in the dog

  1972influential reference
• Canine intervertebral disk disease: characterization by age, sex, breed, and anatomic site of involvement.

  1970cited by this paper
• Morphological Changes Caused by Pressure on the Spinal Cord

  1969influential reference
• Intervertebral disc protrusions in the dog. I. Incidence and pathological lesions.

  1953cited by this paper
• Intervertebral disc protrusions in the dog. II. Symptomatology and clinical diagnosis.

  1953influential reference
• A pathologic-anatomical study on disc degeneration in dog, with special reference to the so-called enchondrosis intervertebralis.

  1952influential reference

• Combining Metabolomics and Proteomics to Reveal Key Serum Compounds Related to Canine Intervertebral Disc Herniation

  2025cites this paper
• Assessing Neurogenic Lower Urinary Tract Dysfunction after Spinal Cord Injury: Animal Models in Preclinical Neuro-Urology Research

  2023cites this paper
• Extrusión del disco intervertebral intradural-intramedular en un Schnauzer de seis meses de edad

  2023cites this paper
• Characterization of microglia/macrophage phenotypes in the spinal cord following intervertebral disc herniation

  2022cites this paper
• Long non-coding RNA-small nucleolar RNA host gene 7 regulates inflammatory responses following spinal cord injury by regulating the microRNA-449a/TNF-α-induced protein 3-interacting protein 2 axis

  2022cites this paper
• Circulating neutrophil activation in dogs with naturally occurring spinal cord injury secondary to intervertebral disk herniation.

  2022cites this paper
• Intramuscular tetanus neurotoxin reverses muscle atrophy: a randomized controlled trial in dogs with spinal cord injury

  2021cites this paper
• A Comparison Between Body Weight-Supported Treadmill Training and Conventional Over-Ground Training in Dogs With Incomplete Spinal Cord Injury

  2021cites this paper
• Development of a Canine Rigid Body Musculoskeletal Computer Model to Evaluate Gait

  2020cites this paper
• Relationship between Machine-Learning Image Classification of T2-Weighted Intramedullary Hypointensity on 3 Tesla Magnetic Resonance Imaging and Clinical Outcome in Dogs with Severe Spinal Cord Injury

  2020cites this paper
• An In Vitro Comparison of the Neurotrophic and Angiogenic Activity of Human and Canine Adipose-Derived Mesenchymal Stem Cells (MSCs): Translating MSC-Based Therapies for Spinal Cord Injury

  2020cites this paper
• Stiffness-matched biomaterial implants for cell delivery: clinical, intraoperative ultrasound elastography provides a ‘target’ stiffness for hydrogel synthesis in spinal cord injury

  2020cites this paper
• Comparison of Gait Assessment Scales in Dogs with Spinal Cord Injury from Intervertebral Disc Herniation

  2020cites this paper
• Current Insights Into the Pathology of Canine Intervertebral Disc Extrusion-Induced Spinal Cord Injury

  2020cites this paper
• Influence of Duration of Injury on Diffusion Tensor Imaging in Acute Canine Spinal Cord Injury

  2020cites this paper
• Interobserver agreement of an electronic von Frey device for measuring mechanical sensory thresholds in normal dogs.

  2019cites this paper
• Urological Sequelae to Acute Spinal Cord Injury in Pet Dogs: A Natural Disease Model of Neuropathic Bladder Dysfunction.

  2019cites this paper
• Large Animal Models for the Clinical Application of Human Induced Pluripotent Stem Cells

  2019cites this paper
• Canine Snake-Eye Myelopathy: Clinical, Magnetic Resonance Imaging, and Pathologic Findings in Four Cases

  2019cites this paper
• Matrix metalloproteinase signals following neurotrauma are right on cue

  2019cites this paper
• Generation and characterization of highly purified canine Schwann cells from spinal nerve dorsal roots as potential new candidates for transplantation strategies

  2018cites this paper
• Development of an International Canine Spinal Cord Injury (CSCI) observational registry: a collaborative data-sharing network to optimize translational studies of SCI

  2018cites this paper
• Beneficial and detrimental impact of transplanted canine adipose-derived stem cells in a virus-induced demyelinating mouse model.

  2018cites this paper
• The role of diffusion tensor imaging as an objective tool for the assessment of motor function recovery after paraplegia in a naturally-occurring large animal model of spinal cord injury

  2018cites this paper
• Therapeutic efficacy of microtube-embedded chondroitinase ABC in a canine clinical model of spinal cord injury

  2018cites this paper
• Translation: Relevance of Spinal Cord Injury Animal Models

  2017cites this paper
• Inflammatory Processes Associated with Canine Intervertebral Disc Herniation

  2017cites this paper
• Canine Pluripotent Stem Cells: Preclinical Model for Stem Cell Based Regenerative Medicine

  2017cites this paper
• Correlation between severity of clinical signs and transcranial magnetic motor evoked potentials in dogs with intervertebral disc herniation.

  2017cites this paper
• Spontaneous acute and chronic spinal cord injuries in paraplegic dogs: a comparative study of in vivo diffusion tensor imaging

  2017cites this paper
• The Association of Specific Constituents of the Fecal Microbiota with Immune-Mediated Brain Disease in Dogs

  2017cites this paper
• Morphologic features of spontaneous annular tears and disc degeneration in the aging sand rat (Psammomys obesus obesus)

  2017cites this paper
• Beyond the Laboratory, Into the Clinic: What Dogs with Disk Disease Have Taught Us About Photobiomodulation for Spinal Cord Injury

  2017influential citation
• Chronic post-traumatic intramedullary lesions in dogs, a translational model

  2017cites this paper
• Early Blockade of Matrix Metalloproteinases in Spinal-Cord–Injured Dogs Results in a Long-Term Increase in Bladder Compliance

  2017cites this paper
• Preliminary evaluation of the effects of photobiomodulation therapy and physical rehabilitation on early postoperative recovery of dogs undergoing hemilaminectomy for treatment of thoracolumbar intervertebral disk disease.

  2017cites this paper
• Clinical and magnetic resonance imaging features of compressive cervical myelopathy with traumatic intervertebral disc herniation in cynomolgus macaque (Macaca fascicularis)

  2016cites this paper
• Arachidonic acid pathway alterations in cerebrospinal fluid of dogs with naturally occurring spinal cord injury

  2016cites this paper
• A simplified method of walking track analysis to assess short-term locomotor recovery after acute spinal cord injury caused by thoracolumbar intervertebral disc extrusion in dogs.

  2016cites this paper
• Practice patterns in the management of acute intervertebral disc herniation in dogs.

  2016cites this paper
• Surgical treatment of spinal cord compression in client owned dogs with different grades of neurological dysfunction.

  2016influential citation
• Temporal characterization and prognostic value determination of severe spinal cord injuries in paraplegic dogs using in vivo diffusion tensor imaging

  2016influential citation
• In vitro phenotypical and transcriptomic characterization of canine macrophages

  2016influential citation
• The Role of Spasticity in Functional Neurorehabilitation- Part I: The Pathophysiology of Spasticity, the Relationship with the Neuroplasticity, Spinal Shock and Clinical Signs

  2016cites this paper
• Bandscheiben und Wirbelsäulen im Vergleich: Hund und Mensch

  2016cites this paper
• Longitudinal extension of myelomalacia by intramedullary and subdural hemorrhage in a canine model of spinal cord injury.

  2016cites this paper
• Quantitative magnetic resonance imaging in a naturally occurring canine model of spinal cord injury

  2015cites this paper
• Companion animals: Translational scientist’s new best friends

  2015cites this paper
• Feasibility Study of Canine Epidermal Neural Crest Stem Cell Transplantation in the Spinal Cords of Dogs

  2015cites this paper
• Acute Phase Proteins in Cerebrospinal Fluid from Dogs with Naturally-Occurring Spinal Cord Injury

  2015cites this paper
• Development of a neuromusculoskeletal computer model in a chondrodystrophic dog.

  2015cites this paper
• Spinal Cord Ependymal Responses to Naturally Occurring Traumatic Spinal Cord Injury in Dogs

  2015influential citation
• Accuracy and Safety of Image Guided Percutaneous Injection of Gelified Ethanol (Discogel®) in the Intervertebral Disc in Dogs

  2015cites this paper
• Stem Cells in Canine Spinal Cord Injury – Promise for Regenerative Therapy in a Large Animal Model of Human Disease

  2015influential citation
• The Role of Nonimaging‐Based Diagnostic Studies for Intervertebral Disc Herniation

  2014cites this paper
• Gait scoring in dogs with thoracolumbar spinal cord injuries when walking on a treadmill

  2014cites this paper
• Potassium Channel Antagonists 4-Aminopyridine and the T-Butyl Carbamate Derivative of 4-Aminopyridine Improve Hind Limb Function in Chronically Non-Ambulatory Dogs; A Blinded, Placebo-Controlled Trial

  2014cites this paper
• Neuroprotective Treatments for Acute Spinal Cord Injury Associated with Intervertebral Disc Herniation

  2014cites this paper
• Relationships between cerebrospinal fluid characteristics, injury severity, and functional outcome in dogs with and without intervertebral disk herniation.

  2014cites this paper
• Efficacy of a Metalloproteinase Inhibitor in Spinal Cord Injured Dogs

  2014influential citation
• Spontaneous regression of lumbar Hansen type 1 disk extrusion detected with magnetic resonance imaging in a dog.

  2014cites this paper
• Award Number: W81XWH-11-1-0797 TITLE: Matrix etalloproteinases as a herapeutic arget to mprove eurologic ecovery fter pinal ord njury

  2014cites this paper
• Acute spinal cord injury: tetraplegia and paraplegia in small animals.

  2014cites this paper
• Cerebrospinal Fluid Inflammatory Cytokines and Chemokines in Naturally Occurring Canine Spinal Cord Injury

  2014cites this paper
• Canine Epidermal Neural Crest Stem Cells: Characterization and Potential as Therapy Candidate for a Large Animal Model of Spinal Cord Injury

  2014cites this paper
• Comparisons between Biped (Human) and Quadruped (Canine/Feline) Intervertebral Disc Disease

  2014cites this paper
• Spatio‐Temporal Development of Axonopathy in Canine Intervertebral Disc Disease as a Translational Large Animal Model for Nonexperimental Spinal Cord Injury

  2013influential citation
• Animal Models of Spinal Cord Injury

  2013cites this paper
• REMOTE DISRUPTION OF FUNCTION, PLASTICITY, AND LEARNING IN LOCOMOTOR NETWORKS AFTER SPINAL CORD INJURY

  2013cites this paper
• The use of an electronic von Frey device for evaluation of sensory threshold in neurologically normal dogs and those with acute spinal cord injury.

  2013cites this paper
• Clinical and pathological analysis of epidural inflammation in intervertebral disk extrusion in dogs.

  2013cites this paper
• Magnetic Resonance Imaging in Cadaver Dogs With Metallic Vertebral Implants at 3 Tesla: Evaluation of the WARP-Turbo Spin Echo Sequence

  2013cites this paper
• Thoracic and lumbar spinal cord diffusion tensor imaging in dogs

  2013cites this paper
• The role of pro- and anti-inflammatory cytokines in the pathogenesis of spontaneous canine CNS diseases.

  2012cites this paper
• Novel Use of Dual Anti-Inflammatory Therapy to Overcome Drug Resistance and Improve Functional Recovery Following Spinal Cord Injury

  2012cites this paper
• International Archives of Medicine the Importance of the Quadruped Animal Model in Functional Neurorehabilitation for Human Biped Review

  year unknowncites this paper