Aldose reductase gene is associated with diabetic macroangiopathy in Japanese Type 2 diabetic patients

A. Watarai,E. Nakashima,Yoji Hamada,G. Watanabe,Keiko Naruse,K. Miwa,Y. Kobayashi,Hideki Kamiya,M. Nakae,Nobuyuki Hamajima,Yoshitaka Sekido,Toshimitsu Niwa,Yutaka Oiso,Jiro Nakamura

Published 2006 in Diabetic Medicine

ABSTRACT

Aims  The aldose reductase (AR) gene, a rate‐limiting enzyme of the polyol pathway, has been investigated as a candidate gene in determining susceptibility to diabetic microangiopathy. However, the association of the AR gene with diabetic macroangiopathy has not been investigated. Therefore, the present study was conducted to determine whether genetic variations of AR may determine susceptibility to diabetic macroangiopathy.

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