XRCC3 Thr241Met gene polymorphisms and lung cancer risk: a meta-analysis

Many studies have examined the association between the XRCC3 Thr241Met gene polymorphism and lung cancer risk in various populations, but their results have been inconsistent. To assess this relationship more precisely, a meta-analysis was performed. The PubMed, Embase, Web of Science, and CNKI database was searched for case–control studies published up to July 2012. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated.Ultimately, 17 studies, comprising 4123 lung cancer cases and 5597 controls were included. Overall, for T allele carriers (TC + TT) versus the wild-type homozygotes (CC), the pooled OR was 0.95 (95% CI = 0.87-1.04 P = 0.228 for heterogeneity), for TT versus CC the pooled OR was 0.99 (95% CI = 0.86-1.15 P = 0.315 for heterogeneity). In the stratified analysis by ethnicity, histological types of lung cancer and smoking status, no any significantly risks were found for (C/T + T/T) vs C/C or T/T vs C/C. No publication bias was found by using the funnel plot and Egger's test.Overall, there is no evidence showing a significant correlation between XRCC3 Thr241Met polymorphism and lung cancer risk stratified analysis by ethnicity, histology and smoking status.

• Publication year

  2013

• Venue

  Journal of experimental & clinical cancer research : CR

• Publication date

  2013-01-04

• Fields of study

  Medicine

• Identifiers
  DOI 10.1186/1756-9966-32-1PMID 23289442PMCID 3557200
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Genetic Polymorphisms Involved in Carcinogen Metabolism and DNA Repair and Lung Cancer Risk in a Japanese Population

  2012cited by this paper
• Association of genetic polymorphisms in DNA repair pathway genes with non-small cell lung cancer risk.

  2011cited by this paper
• APE1 Asp148Glu gene polymorphism and bladder cancer risk: a meta-analysis

  2011cited by this paper
• ERCC2/XPD Lys751Gln and Asp312Asn Gene Polymorphism and Lung Cancer Risk: A Meta-Analysis Involving 22 Case–Control Studies

  2010cited by this paper
• APEX1 Asp148Glu gene polymorphism is a risk factor for lung cancer in relation to smoking in Japanese.

  2010cited by this paper
• APE1 Asp148Glu gene polymorphism and lung cancer risk: a meta-analysis

  2010cited by this paper
• Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship.

  2008cited by this paper
• Association of single nucleotide polymorphisms of DNA repair gene XRCC3-241 with non-small cell lung cancer

  2008cited by this paper
• Polymorphisms of the DNA repair genes XRCC1 and XRCC3 and risk of lung and colorectal cancer: a case-control study in a Southern Italian population.

  2008cited by this paper
• Polymorphisms in XPC, XPD, XRCC1, and XRCC3 DNA repair genes and lung cancer risk in a population of Northern Spain

  2007cited by this paper
• [Relationship between polymorphisms of DNA repair gene XRCC3 and susceptibility to lung cancer].

  2007cited by this paper
• DNA repair polymorphisms and cancer risk in non-smokers in a cohort study.

  2006cited by this paper
• Polymorphisms of DNA repair genes and risk of non-small cell lung cancer.

  2006cited by this paper
• Never-smokers with lung cancer: epidemiologic evidence of a distinct disease entity.

  2006cited by this paper
• Polymorphisms in the DNA repair genes XRCC1, APEX1, XRCC3 and NBS1, and the risk for lung cancer in never- and ever-smokers.

  2006cited by this paper
• ERCC2 /XPD gene polymorphisms and lung cancer: a HuGE review.

  2005cited by this paper
• Polymorphisms in DNA repair genes, chromosome aberrations, and lung cancer

  2004cited by this paper
• XRCC3 polymorphisms and risk of lung cancer.

  2004cited by this paper
• Specific combinations of DNA repair gene variants and increased risk for non-small cell lung cancer.

  2004cited by this paper
• Polymorphisms in the DNA repair genes XPD, XRCC1, XRCC3, and APE/ref-1, and the risk of lung cancer among male smokers in Finland.

  2003cited by this paper
• XRCC3 genetic polymorphism, smoking, and lung carcinoma risk in minority populations

  2003cited by this paper
• A comprehensive review of genetic association studies

  2002cited by this paper
• XRCC1, XRCC3, XPD gene polymorphisms, smoking and (32)P-DNA adducts in a sample of healthy subjects.

  2001cited by this paper
• Genetic polymorphisms of XRCC1 and risk of the esophageal cancer

  2001cited by this paper
• No association between the XPD (Lys751G1n) polymorphism or the XRCC3 (Thr241Met) polymorphism and lung cancer risk.

  2001cited by this paper
• Modulation of nucleotide excision repair capacity by XPD polymorphisms in lung cancer patients.

  2001cited by this paper
• Assessing the influence of a single study in the meta-anyalysis estimate

  1999cited by this paper
• Bias in meta-analysis detected by a simple, graphical test

  1997cited by this paper
• Family History and Risk of Fatal Prostate Cancer

  1997cited by this paper
• Correction of chromosomal instability and sensitivity to diverse mutagens by a cloned cDNA of the XRCC3 DNA repair gene.

  1995cited by this paper
• Difference of allelotype between squamous cell carcinoma and adenocarcinoma of the lung.

  1994cited by this paper
• Epidemiology of lung cancer.

  1994cited by this paper
• Meta-analysis in clinical trials.

  1986cited by this paper
• Statistical aspects of the analysis of data from retrospective studies of disease.

  1959cited by this paper
• The combination of estimates from different experiments.

  1954influential reference

• High-Throughput Metabolomic Profiling of Skin Lesions: Comparative Study of Cutaneous Squamous Cell Carcinoma, Basal Cell Carcinoma, and Normal Skin Via e-Biopsy Sampling

  2025cites this paper
• Telomerase in Cancer Therapeutics.

  2024cites this paper
• Unveiling the Impact of Hemodynamics on Endothelial Inflammation‐Mediated Hepatocellular Carcinoma Metastasis Using a Biomimetic Vascular Flow Model

  2024cites this paper
• Wnt/β-catenin signalling, epithelial-mesenchymal transition and crosslink signalling in colorectal cancer cells.

  2024cites this paper
• Semi-synthesized anticancer theobromine derivatives targeting VEGFR-2: in silico and in vitro evaluations

  2023cites this paper
• Is reactive oxygen species the only way for cancer inhibition over single atom nanomedicine? Autophagy regulation also works

  2023cites this paper
• Association between XRCC3 rs861539 Polymorphism and the Risk of Ovarian Cancer: Meta-Analysis and Trial Sequential Analysis

  2022cites this paper
• Association of genetic polymorphisms in DNA repair genes ERCC2 Asp312Asn (rs1799793), ERCC2 Lys 751 Gln (rs13181), XRCC1 Arg399 Gln (rs25487) and XRCC3 Thr 241Met (rs861539) with the susceptibility of lung cancer in Saudi population

  2022cites this paper
• A review on the role of DANCR in the carcinogenesis

  2022cites this paper
• Role of different non-coding RNAs as ovarian cancer biomarkers

  2022cites this paper
•  Combined treatment with inhibitors of ErbB Receptors and Hh signaling pathways is more effective than single treatment in reducing the growth of malignant mesothelioma both in vitro and in vivo

  2022cites this paper
• Association between the DNA Repair Gene Polymorphisms and Lung Cancer in Turkish Population

  2022cites this paper
• Molecular docking and molecular dynamic simulations of apoptosis proteins with potential anticancer compounds present in Clinacanthus nutans extract using gas chromatography–mass spectrometry

  2022cites this paper
• Application of solid-phase extraction (SPE) and high-performance liquid chromatography (HPLC) and comparison of both detection techniques (DAD and FLD) to analyse nesfatin-1 in fetal bovine serum samples

  2022cites this paper
• Heterotypic tumor models through freeform printing into photostabilized granular microgels.

  2021cites this paper
• Molecular and therapeutic bases of cancer

  2021cites this paper
• Quantitative assessments of late radiation-induced skin and soft tissue toxicity and correlation with RTOG scales and biological equivalent dose in breast cancer

  2021cites this paper
• Is targeting autophagy mechanism in cancer a good approach? The possible double-edge sword effect

  2021cites this paper
• Design, synthesis and investigation of procaine based new Pd complexes as DNA methyltransferase inhibitor on gastric cancer cells

  2021cites this paper
• XRCC2 Arg188His polymorphism and colorectal cancer risk: a meta-analysis

  2021cites this paper
• Zinc coordination complexes as anticancer agents

  2021cites this paper
• EGR1-CCL2 Feedback Loop Maintains Epithelial-Mesenchymal Transition of Cisplatin-Resistant Gastric Cancer Cells and Promotes Tumor Angiogenesis

  2021cites this paper
• Freeform printing of heterotypic tumor models within cell-laden microgel matrices

  2020cites this paper
• Zinc(II) Complexes of Acylpyrazolones Decorated with a Cyclohexyl Group Display Antiproliferative Activity Against Human Breast Cancer Cells

  2020cites this paper
• Analysis of the association between the XRCC2 rs3218536 polymorphism and ovarian cancer risk

  2020cites this paper
• Calcium Permeable Channels in Cancer Hallmarks

  2020cites this paper
• A Retrospective Dosimetric Study of Radiotherapy Patients with Left-Sided Breast Cancer; Patient Selection Criteria for Deep Inspiration Breath Hold Technique

  2019cites this paper
• Expression Level of miR-34a in Tumor Tissue from Patients with Esophageal Squamous Cell Carcinoma

  2019cites this paper
• Poly(ADP-ribose) polymerase enzymes and the maintenance of genome integrity

  2019cites this paper
• G-quadruplex ligand RHPS4 radiosensitizes glioblastoma xenograft in vivo through a differential targeting of bulky differentiated- and stem-cancer cells

  2019cites this paper
• Targeting epidermal growth factor receptor pathway with irreversible tyrosine kinase inhibitor

  2019cites this paper
• Antitumor and anti‐metastatic mechanisms of Rhizoma paridis saponins in Lewis mice

  2018cites this paper
• Paclitaxel-loaded folate-coated long circulating and pH-sensitive liposomes as a potential drug delivery system: A biodistribution study.

  2018cites this paper
• Targeting the Wnt/beta-catenin pathway in cancer: Update on effectors and inhibitors.

  2018cites this paper
• Cell Spheroids with Enhanced Aggressiveness to Mimic Human Liver Cancer In Vitro and In Vivo

  2017cites this paper
• miRsig: a consensus-based network inference methodology to identify pan-cancer miRNA-miRNA interaction signatures

  2017cites this paper
• Genetic polymorphisms and lung cancer risk: Evidence from meta-analyses and genome-wide association studies.

  2017cites this paper
• Interleukin-27 augments the inhibitory effects of sorafenib on bladder cancer cells

  2017cites this paper
• G allele at −924 A > G position of FoxP3 gene promoter as a risk factor for tuberculosis

  2017cites this paper
• IGF-IR signaling in epithelial to mesenchymal transition and targeting IGF-IR therapy: overview and new insights

  2017cites this paper
• An interaction between cancer progression and social environment in Drosophila

  2017cites this paper
• Haplotype Based Analysis of XRCC3 Gene Polymorphisms in Thyroid Cancer

  2017cites this paper
• Three-dimensional Image-based Mechanical Modeling for Predicting the Response of Breast Cancer to Neoadjuvant Therapy.

  2017cites this paper
• EGFR as a Pharmacological Target in EGFR-Mutant Non-Small-Cell Lung Cancer: Where Do We Stand Now?

  2016cites this paper
• Comment on: “Association Between the XRCC3 Thr241Met Polymorphism and Risk of Colorectal Cancer: A Meta-Analysis of 5,193 Cases and 6,645 Controls”

  2016cites this paper
• A potent betulinic acid analogue ascertains an antagonistic mechanism between autophagy and proteasomal degradation pathway in HT-29 cells

  2016cites this paper
• Association between XRCC3 Thr241Met Polymorphism and the Risk of Cancer in Northern Brazil

  2016cites this paper
• Synthesis of a stable and orally bioavailable englerin analogue.

  2016cites this paper
• The role of IL-37 in cancer

  2016cites this paper
• Liquid Biopsy in Non-Small Cell Lung Cancer

  2016cites this paper
• XRCC3 Thr241Met Polymorphism is not Associated with Lung Cancer Risk in a Romanian Population

  2016cites this paper
• Platelet-derived growth factor receptor/platelet-derived growth factor (PDGFR/PDGF) system is a prognostic and treatment response biomarker with multifarious therapeutic targets in cancers

  2016cites this paper
• Mining the coding and non-coding genome for cancer drivers.

  2015cites this paper
• Contribution of X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 3 (XRCC3) Genotype to Leiomyoma Risk.

  2015cites this paper
• Hyperphosphorylation of ribosomal protein S6 predicts unfavorable clinical survival in non-small cell lung cancer

  2015cites this paper
• Polymorphism of the XRCC3 gene and risk of gastric cancer in a Kashmiri population: a case–control study

  2015cites this paper
• Radiation responses of stem cells: targeted and non-targeted effects.

  2015cites this paper
• The Expression and Significance of the Plasma Let-7 Family in Anti-N-methyl-d-aspartate Receptor Encephalitis

  2015cites this paper
• Inflammatory models drastically alter tumor growth and the immune microenvironment in hepatocellular carcinoma

  2015cites this paper
• ASSOCIATION BETWEEN MURINE DOUBLE MINUTE 2 - T309G polymorphism and recurrence of hepatocellular carcinoma after surgical treatment.

  2015cites this paper
• MiR-16 targets Bcl-2 in paclitaxel-resistant lung cancer cells and overexpression of miR-16 along with miR-17 causes unprecedented sensitivity by simultaneously modulating autophagy and apoptosis.

  2015cites this paper
• Association between XRCC3 Thr241Met polymorphism and laryngeal cancer susceptibility in Turkish population

  2015cites this paper
• Association between the XRCC3 Thr241Met polymorphism and risk of colorectal cancer: a meta analysis of 5,193 cases and 6,645 controls.

  2015cites this paper
• Let-7b-5p regulates proliferation and apoptosis in multiple myeloma by targeting IGF1R.

  2014cites this paper
• The histone acetylranseferase hMOF acetylates Nrf2 and regulates anti‐drug responses in human non‐small cell lung cancer

  2014cites this paper
• [Association of the nicotine and cigarette smoke toxicants metabolic (CHRNA3/5, CYP2A6, NQO1) and DNA repair genes (XRCC1, XRCC3, XPC, XPA) with chronic obstructive pulmonary disease].

  2014cites this paper
• The Effect of Insulin Resistance on Breast Cancer Risk in Latinas of Mexican Origin

  2014cites this paper
• The histone acetyltransferase hMOF suppresses hepatocellular carcinoma growth.

  2014cites this paper
• Extracellular vesicles shed by glioma cells: pathogenic role and clinical value

  2014cites this paper
• Association of genes involved in nicotine and tobacco smoke toxicant metabolism (CHRNA3/5, CYP2A6, and NQO1) and DNA repair (XRCC1, XRCC3, XPC, and XPA) with chronic obstructive pulmonary disease

  2014cites this paper
• DNA repair gene XRCC3 Thr241Met polymorphism and susceptibility to glioma: A case-control study

  2014cites this paper
• Analyzing Association of the XRCC3 Gene Polymorphism with Ovarian Cancer Risk

  2014cites this paper
• XRCC3 T241M polymorphism and lung cancer risk in the Han Chinese population: a meta-analysis.

  2014cites this paper
• DNA repair gene XRCC3 Thr241Met polymorphism and hepatocellular carcinoma risk

  2013cites this paper
• Association of Thr241Met polymorphism of XRCC3 gene with risk of colorectal cancer in the Polish population.

  2013cites this paper
• Association between XRCC1 and XRCC3 Polymorphisms with Lung Cancer Risk: A Meta-Analysis from Case-Control Studies

  2013cites this paper
• The investigation of 125I seed implantation as a salvage modality for unresectable pancreatic carcinoma

  2013cites this paper
• THE ASSOCIATION OF DNA REPAIR GENE XRCC3 T241M POLYMORPHISM AND THE RISK OF HCV INDUCED HCC IN A COHORT FROM THE EGYPTIAN POPULATION

  year unknowncites this paper