Use of platelet rich plasma to treat plantar fasciitis: design of a multi centre randomized controlled trial

BackgroundIf conservative treatment for chronic plantar fasciitis fails, often a corticosteroid injection is given. Corticosteroid injection gives temporarily pain reduction, but no healing. Blood platelets initiate the natural healing rate. GPS® gives an eightfold concentrate platelets of patients own blood. Injection of these platelets in the attachment of the fascia to the os calcis might induce a healing rate.Methods and designA randomized controlled multi centre trial will be performed. The study population consists of 120 patients of 18 years and older. Patients with chronic plantar fasciitis will be allocated randomly to have a steroid injection or an autologous platelet concentrate injections. Data will be collected before the procedure, 4,8,12,26 weeks and 1 year after the procedure.The main outcome measures of this study are pain and function measured with questionnaires.ConclusionRecent literature show positive effects for the treatment of tendinosis with autologous platelet injections. The forthcoming trial will compare treatment for chronic plantar fasciitis with a steroid injection versus an autologous platelet injection. Our results will be published as soon as they become available.Trial RegistrationTrial registration number: http://www.clinicaltrials.gov NCT00758641.

• Publication year

  2010

• Venue

  BMC Musculoskeletal Disorders

• Publication date

  2010-04-14

• Fields of study

  Medicine

• Identifiers
  DOI 10.1186/1471-2474-11-69PMID 20398269PMCID 2861637
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Positive Effect of an Autologous Platelet Concentrate in Lateral Epicondylitis in a Double-Blind Randomized Controlled Trial

  2010cited by this paper
• Interventions for treating plantar heel pain.

  2010cited by this paper
• The real risks of steroid injection for plantar fasciitis, with a review of conservative therapies

  2008cited by this paper
• Platelet-rich plasma inhibits demineralized bone matrix-induced bone formation in nude mice.

  2007cited by this paper
• Current concepts in the treatment of intra-articular calcaneal fractures: results of a nationwide survey

  2007cited by this paper
• Current opinion about using the platelet-rich gel in orthopaedics and trauma surgery.

  2007cited by this paper
• Validation of the Dutch Version of the CDC Core Healthy Days Measures in a Community Sample

  2006cited by this paper
• Plantar fascia-specific stretching exercise improves outcomes in patients with chronic plantar fasciitis. A prospective clinical trial with two-year follow-up.

  2006cited by this paper
• Plantar fasciitis treated with local steroid injection: comparison between sonographic and palpation guidance

  2006cited by this paper
• Plantar fasciitis: evidence-based review of diagnosis and therapy.

  2005influential reference
• Validation of the WHO Quality of Life assessment instrument (WHOQOL-100) in a population of Dutch adult psychiatric outpatients

  2005cited by this paper
• Modulation of Wound Response and Soft Tissue Ingrowth in Synthetic and Allogeneic Implants With Platelet Concentrate

  2005cited by this paper
• Reliability of the Foot Function Index: A Report of the AOFAS Outcomes Committee

  2005cited by this paper
• Functional Limitations of Patients with End-Stage Ankle Arthrosis

  2005cited by this paper
• Modulation of Wound Response With Growth Factors and Platelet Concentrate

  2005cited by this paper
• Clinical practice. Plantar fasciitis.

  2004cited by this paper
• Plantar fasciitis

  2004cited by this paper
• Extracorporeal shock wave therapy for plantar fasciitis.

  2003cited by this paper
• Plantar fasciitis: a degenerative process (fasciosis) without inflammation.

  2003influential reference
• “Extracorporeal shock wave therapy for lateral epicondylitis—a double blind randomized controlled trial”, by Speed CA, Nichols D, Richards C, Humphreys H, Wies JT, Burnet S, Hazleman BL [Journal of Orthopaedic Research 29 (2002) 895–898]

  2003cited by this paper
• The Roles of Growth Factors in Tendon and Ligament Healing

  2003influential reference
• Extracorporeal shock wave therapy for plantar fasciitis. A double blind randomised controlled trial

  2003cited by this paper
• Autologous blood injections for refractory lateral epicondylitis.

  2003cited by this paper
• A retrospective case-control analysis of 2002 running injuries

  2002cited by this paper
• The foot function index with verbal rating scales (FFI-5pt): A clinimetric evaluation and comparison with the original FFI.

  2002cited by this paper
• Comparison of Custom and Prefabricated Orthoses in the Initial Treatment of Proximal Plantar Fasciitis

  1999cited by this paper
• Plantar Fasciitis: How Successful Is Surgical Intervention?

  1999cited by this paper
• Outcome Study of Subjects with Insertional Plantar Fasciitis

  1998cited by this paper
• Complications of Plantar Fascia Rupture Associated with Corticosteroid Injection

  1998cited by this paper
• Plantar Fascia Rupture Associated with Corticosteroid Injection

  1994cited by this paper
• Conservative Treatment of Plantar Heel Pain: Long-Term Follow-Up

  1994cited by this paper
• Clinical Rating Systems for the Ankle-Hindfoot, Midfoot, Hallux, and Lesser Toes

  1994cited by this paper
• Elbow tendinosis/tennis elbow.

  1992cited by this paper
• Elbow Tendinosis/Tennis Elbow

  1992cited by this paper
• The Foot Function Index: a measure of foot pain and disability.

  1991cited by this paper
• Rupture of the plantar fascia in athletes.

  1978cited by this paper

• Platelet-Rich Plasma Loaded Alginate-Based Injectable Hydrogel for Meniscal Tear Repair: In Vivo Evaluation in Lapine Model.

  2025cites this paper
• Platelet-rich Plasma in Orthopedics: Unraveling Cellular Mechanisms, Therapeutic Potential, and Limitations

  2025cites this paper
• Comprehensive Review and Evidence-Based Treatment Framework for Optimizing Plantar Fasciitis Diagnosis and Management

  2025cites this paper
• Ultrasound-guided prolotherapy versus corticosteroid injections for the treatment of patients with plantar fasciitis: A randomized controlled trial

  2024cites this paper
• A Prospective Study of the Effectiveness of Autologous Platelet - Rich Plasma Injection in Chronic Plantar Fasciitis

  2024cites this paper
• High-resolution Ultrasonographic Diagnosis of Plantar Fasciitis: An Association of Magnetic Resonance Imaging and Ultrasound

  2023cites this paper
• Effect of platelet-rich plasma versus steroid injection in plantar fasciitis: a randomized clinical trial

  2023cites this paper
• The Effect of Short and Long-Term Therapeutic Treatment with Insoles and Shoes on Pain, Function, and Plantar Load Parameters of Women with Plantar Fasciitis: A Randomized Controlled Trial

  2022cites this paper
• Autologous blood products: Usage and preparation protocols.

  2022cites this paper
• Prediction of clinical response to corticosteroid or platelet-rich plasma injection in plantar fasciitis with MRI: A prospective, randomized, double-blinded study.

  2021cites this paper
• Platelet-rich Plasma Has Better Mid-term Clinical Results than Traditional Steroid injection for Plantar Fasciitis: A systematic review and meta-analysis.

  2021cites this paper
• Histological and Histomorphometric Evaluation of Applying a Bioactive Advanced Platelet-Rich Fibrin to a Perforated Schneiderian Membrane in a Maxillary Sinus Elevation Model

  2020cites this paper
• JALAUKĀVACARAṆA IN PLANTAR FASCIITIS

  2020cites this paper
• Outcomes of platelet-rich plasma for plantar fasciopathy: a best-evidence synthesis

  2020cites this paper
• Inflammatory cell profile using different autologous fibrin protocols.

  2020cites this paper
• Positive Effect of Platelet-Rich Plasma on Pain in Plantar Fasciitis: Letter to the Editor

  2020cites this paper
• Liquid platelet-rich fibrin promote the regenerative potential of human periodontal ligament cells.

  2020cites this paper
• Platelet Rich Plasma versus Corticosteroid Local Injection Results in Treatment of Planter Fasciitis in New-Cairo

  2019cites this paper
• Comparison of Three Different Treatment Modalities in the Treatment of Chronic Plantar Fasciitis: Corticosteroid Injection, Extracorporeal Shock Wave Therapy and Radiofrequency Nerve Ablation

  2019cites this paper
• Is Platelet-rich Plasma (PRP) a More Effective Treatment In Reducing Pain than Corticosteroid (CS) Injections in Musculoskeletal Injuries?

  2019cites this paper
• Positive Effect of Platelet-Rich Plasma on Pain in Plantar Fasciitis: A Double-Blind Multicenter Randomized Controlled Trial

  2019cites this paper
• Role of Ultrasonography and Magnetic Resonance Imaging in Assessment of Plantar Fasciitis

  2019cites this paper
• Was It Gold What Shone? Platelet-Rich Plasma Applications, Outcomes and Security Considerations

  2019cites this paper
• Regenerative Medicine Procedures for Aesthetic Physicians

  2019cites this paper
• Percutaneous Plantar Fascia Release With Needle: Anatomic Evaluation with Cadaveric Specimens.

  2019cites this paper
• Application of standardized platelet‐rich plasma in elderly patients with complex wounds

  2019cites this paper
• Randomized controlled study comparing clinical outcomes after injection botulinum toxin type A versus corticosteroids in chronic plantar fasciitis

  2018cites this paper
• Clinical Outcomes Following an Open Gastrocnemius Recession Combined With an Endoscopic Plantar Fasciotomy

  2018cites this paper
• Plantar Fasciitis Treatments

  2018cites this paper
• Effectiveness of Four Different Treatment Modalities in the Treatment of Chronic Plantar Fasciitis During a 36‐Month Follow‐Up Period: A Randomized Controlled Trial

  2018cites this paper
• Regenerative efficacy of therapeutic quality platelet-rich plasma injections versus phonophoresis with kinesiotaping for the treatment of chronic plantar fasciitis: A prospective randomized pilot study

  2018cites this paper
• Pure platelet rich plasma injections in the management of knee osteoarthritis

  2018cites this paper
• Efficacy of High-Intensity Laser Therapy and Silicone Insole in Plantar Fasciitis

  2018cites this paper
• Plantar Fasiitli Hastalarda Kalkaneal Epin Varlığı Ağrı Şiddeti, Fonksiyon ve Yaşam Kalitesini Etkiler mi?

  2018cites this paper
• Clinical recommendations for autologous platelet derivatives used in periodontal regeneration

  2018cites this paper
• The use of platelet-rich plasma to treat chronic tendinopathies: A technical analysis

  2018cites this paper
• Relationship of cytokine levels and clinical effect on platelet‐rich plasma‐treated lateral epicondylitis

  2017cites this paper
• A Call for Standardization in Platelet-Rich Plasma Preparation Protocols and Composition Reporting: A Systematic Review of the Clinical Orthopaedic Literature

  2017cites this paper
• Injectable platelet rich fibrin (i-PRF): opportunities in regenerative dentistry?

  2017cites this paper
• Optimized Platelet‐Rich Fibrin With the Low‐Speed Concept: Growth Factor Release, Biocompatibility, and Cellular Response

  2017cites this paper
• Endoscopic Plantar Fasciotomy; Deep Fascial Versus Superficial Fascial Approach: A Prospective Randomized Study

  2017cites this paper
• Behavior of Gingival Fibroblasts on Titanium Implant Surfaces in Combination with either Injectable-PRF or PRP

  2017cites this paper
• Quel « PRP » pour traiter les tendinopathies chroniques ?

  2017cites this paper
• Injected corticosteroids for treating plantar heel pain in adults.

  2017cites this paper
• Role of leukocyte free platelet rich plasma in planter fasciitis: a prospective study

  2017influential citation
• Chronic Plantar Fasciitis: Effect of Platelet-Rich Plasma, Corticosteroid, and Placebo.

  2016cites this paper
• Platelet-Rich Fibrin and Soft Tissue Wound Healing: A Systematic Review

  2016cites this paper
• The Diagnosis and Treatment of Plantar Fasciitis

  2016cites this paper
• Platelet Rich Plasma In Musculoskeletal Pathologies

  2016cites this paper
• Plantar fasciitis: A randomized comparative study of platelet rich plasma and low dose radiation in sportspersons.

  2016cites this paper
• Effectiveness and relevant factors of platelet-rich plasma treatment in managing plantar fasciitis: A systematic review

  2016cites this paper
• Ultrasound-guided procedures to treat sport-related muscle injuries.

  2016cites this paper
• Endoscopic Debridement for Treatment of Chronic Plantar Fasciitis: An Innovative Technique and Prospective Study of 46 Consecutive Patients.

  2016cites this paper
• Ultrasound-guided intervention in the ankle and foot.

  2016cites this paper
• Plantar fasciitis

  2015cites this paper
• Endoscopic plantar fasciotomy versus injection of platelet-rich plasma for resistant plantar fasciopathy.

  2015cites this paper
• O efeito do plasma rico em plaquetas no reparo de lesões musculares em ratos

  2015cites this paper
• Platelet-rich Plasma: Applications in Sports Medicine

  2015cites this paper
• Comparative effectiveness of autologous blood-derived products, shock-wave therapy and corticosteroids for treatment of plantar fasciitis: a network meta-analysis.

  2015cites this paper
• Platelet-Rich-Plasma injection seems to be effective in treatment of plantar fasciitis: a case series.

  2015cites this paper
• The effect of platelet-rich plasma on the repair of muscle injuries in rats☆

  2015cites this paper
• Platelet-rich plasma (PRP): Methodological aspects and clinical applications

  2015cites this paper
• Platelet derivatives in regenerative medicine: an update.

  2015cites this paper
• Plantar fasciitis: a concise review.

  2014cites this paper
• Autologous Platelet‐Rich Plasma Versus Dextrose Prolotherapy for the Treatment of Chronic Recalcitrant Plantar Fasciitis

  2014cites this paper
• Update on Evidence‐Based Treatments for Plantar Fasciopathy

  2014cites this paper
• Role of Tissue Specific Plantar Fascia Stretching Exercises Versus Myofascial Released Technique in Chronic Plantar Fasciitis

  2014cites this paper
• Platelet-rich plasma injections for chronic plantar fasciopathy: a systematic review.

  2014cites this paper
• The treatment of intractable plantar fasciitis with platelet-rich plasma injection.

  2013cites this paper
• Full-length silicone insoles versus ultrasound-guided corticosteroid injection in the management of plantar fasciitis: A randomized clinical trial

  2013cites this paper
• Platelet Rich Plasma In Sports Medicine

  2013cites this paper
• Prospective, Randomized, Blinded, Comparative Study of Injectable Micronized Dehydrated Amniotic/Chorionic Membrane Allograft for Plantar Fasciitis—A Feasibility Study

  2013cites this paper
• The use of platelet-rich plasma in the nonsurgical management of sports injuries: hype or hope?

  2013cites this paper
• Outcomes and quality of life after platelet-rich plasma therapy in patients with recalcitrant hindfoot and ankle diseases: a preliminary report of 12 patients.

  2013cites this paper
• Platelet-rich plasma application in the management of chronic tendinopathies.

  2013cites this paper
• Autologous Tenocyte Injection for the Treatment of Severe, Chronic Resistant Lateral Epicondylitis

  2013cites this paper
• HGF Mediates the Anti-inflammatory Effects of PRP on Injured Tendons

  2013cites this paper
• Augmentation techniques for isolated meniscal tears

  2013cites this paper
• Local injection of autologous platelet rich plasma and corticosteroid in treatment of lateral epicondylitis and plantar fasciitis: Randomized clinical trial

  2012cites this paper
• Actualités sur l'emploi du PRP dans les tendinopathies

  2012cites this paper
• 2 Myofascial Trigger Point : Symptoms , Diagnosis , Intervention

  2012cites this paper
• Minimally invasive treatment of the KobyGard system for plantar fasciitis: a retrospective study.

  2012cites this paper
• Platelets rich plasma for treatment of chronic plantar fasciitis

  2012cites this paper
• Plantar fasciitis

  2012cites this paper
• Plantar fasciitis

  2012cites this paper
• Myofascial Trigger Point: Symptoms, Diagnosis, Intervention

  2012cites this paper
• Triathlon: Running Injuries

  2012cites this paper
• BONE OR SOFT TISSUE HEALING AND FUSION ENHANCEMENT PRODUCTS

  2012cites this paper
• und therapeutische Optionen

  2012cites this paper
• Managing chronic plantar fasciitis: When conservative strategies fail

  2012cites this paper
• Platelet-rich plasma: a milieu of bioactive factors.

  2012cites this paper
• Epikondylitis – Ätiologie, Diagnostik und therapeutische Optionen

  2012cites this paper
• Tendinopathies et plasma riche en plaquettes (PRP) : applications cliniques. Revue de la littérature

  2012cites this paper
• Applications cliniques du plasma riche en plaquettes (PRP) dans les lésions tendineuses : revue de la littérature

  2012cites this paper
• Diagnosis and treatment of plantar fasciitis.

  2011cites this paper
• Foot Injuries in Runners

  2011cites this paper
• Extra-Venous Use of Autologous Platelet Concentrate: Beginning of a New Era of Therapy of Transfusion Medicine?

  2011cites this paper
• A Prospective Randomized Trial Using Four Treatment Modalities for the Treatment of Plantar Fasciitis

  2011cites this paper
• Autologous Growth Factors: A Biological Treatment in Sports Medicine

  2010cites this paper