Respuesta placebo en la enfermedad de Parkinson: una revisión teórica

Resumen La enfermedad de Parkinson es un trastorno neurodegenerativo que se caracteriza por la presencia de temblor en reposo, bradicinesia y rigidez como consecuencia de la perdida de neuronas dopaminergicas en la via nigroestriatal. El objetivo de esta revision teorica es examinar la respuesta placebo en la enfermedad de Parkinson, recopilando los estudios publicados desde el ano 2000 hasta la actualidad mediante una busqueda bibliografica en las bases de datos Medline, Psycinfo y Scopus. Los resultados indican que, aunque suele haber una clara respuesta a la medicacion antiparkinsoniana, con mejora de los sintomas motores de la enfermedad, tambien se han observado mejoras significativas a nivel motor tras la administracion de placebo, si bien generalmente estos cambios son de corta duracion. Se senalan tambien algunas limitaciones potenciales de esta revision y la importancia que la respuesta placebo tiene tanto para el diseno de trabajos de investigacion como desde el punto de vista clinico.

• Publication year

  2018

• Venue

  Psiquiatría Biológica

• Publication date

  2018-09-01

• Fields of study

  Not labeled

• Identifiers
  DOI 10.1016/J.PSIQ.2018.09.001
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• The placebo effect on resting tremor in Parkinson's disease: an electrophysiological study.

  2018cited by this paper
• A Review of the Theoretical and Biological Understanding of the Nocebo and Placebo Phenomena.

  2017cited by this paper
• The placebo effect on bradykinesia in Parkinson's disease with and without prior drug conditioning

  2017cited by this paper
• Brain Mechanisms of the Placebo Effect: An Affective Appraisal Account.

  2017cited by this paper
• Placebo effects induced by auditory cues decrease parkinsonian rigidity in patients with subthalamic stimulation.

  2016cited by this paper
• Placebo effect of medication cost in Parkinson disease

  2015cited by this paper
• Another face of placebo: The lessebo effect in Parkinson disease

  2014cited by this paper
• Characterization of the thalamic-subthalamic circuit involved in the placebo response through single-neuron recording in Parkinson patients.

  2014cited by this paper
• Network modulation following sham surgery in Parkinson's disease.

  2014cited by this paper
• Motor and cognitive placebo-/nocebo-responses in Parkinson's disease patients with deep brain stimulation.

  2013cited by this paper
• Effect of expectancy and personality on cortical excitability in Parkinson's disease

  2013cited by this paper
• The placebo response: how words and rituals change the patient's brain.

  2011cited by this paper
• Effects of expectation on placebo-induced dopamine release in Parkinson disease.

  2010cited by this paper
• No prefrontal control, no placebo response.

  2010cited by this paper
• Dispositional optimism predicts placebo analgesia.

  2010cited by this paper
• Reproducibility of placebo analgesia: Effect of dispositional optimism

  2009cited by this paper
• Electrophysiological properties of thalamic, subthalamic and nigral neurons during the anti‐parkinsonian placebo response

  2009cited by this paper
• A comprehensive review of the placebo effect: recent advances and current thought.

  2008cited by this paper
• Neural Control of Motion-to-Force Transitions with the Fingertip

  2008cited by this paper
• Placebo Effects

  2008cited by this paper
• A Link between Serotonin-Related Gene Polymorphisms, Amygdala Activity, and Placebo-Induced Relief from Social Anxiety

  2008cited by this paper
• Placebo

  2007cited by this paper
• Expectation and the placebo effect in Parkinson's disease patients with subthalamic nucleus deep brain stimulation

  2006cited by this paper
• Therapeutic application of transcranial magnetic stimulation in Parkinson's disease: The contribution of expectation

  2006cited by this paper
• Immediate Placebo Effect in Parkinson’s Disease – Is the Subjective Relief Accompanied by Objective Improvement?

  2006cited by this paper
• Expectation enhances autonomic responses to stimulation of the human subthalamic limbic region.

  2005cited by this paper
• Reconsidering the role of personality in placebo effects: dispositional optimism, situational expectations, and the placebo response.

  2005cited by this paper
• Increased placebo analgesia over time in irritable bowel syndrome (IBS) patients is associated with desire and expectation but not endogenous opioid mechanisms

  2005cited by this paper
• Uncovering the hidden placebo effect in deep-brain stimulation for Parkinson's disease

  2004cited by this paper
• Effects of perceived treatment on quality of life and medical outcomes in a double-blind placebo surgery trial.

  2004cited by this paper
• Placebo-responsive Parkinson patients show decreased activity in single neurons of subthalamic nucleus

  2004cited by this paper
• Conscious Expectation and Unconscious Conditioning in Analgesic, Motor, and Hormonal Placebo/Nocebo Responses

  2003cited by this paper
• Dopamine release in human ventral striatum and expectation of reward.

  2002cited by this paper
• The contribution of suggestibility and expectation to placebo analgesia phenomenon in an experimental setting

  2002cited by this paper
• Expectation modulates the response to subthalamic nucleus stimulation in Parkinsonian patients

  2002cited by this paper
• Expectation and Dopamine Release: Mechanism of the Placebo Effect in Parkinson's Disease

  2001cited by this paper
• The placebo response. Recent research and implications for family medicine.

  2000cited by this paper
• Neuropharmacological Dissection of Placebo Analgesia: Expectation-Activated Opioid Systems versus Conditioning-Activated Specific Subsystems

  1999cited by this paper
• The mechanism of placebo analgesia.

  1978cited by this paper
• S C I E N C E a N D S O C I E T Y

  year unknowncited by this paper

• No citing papers are available for this paper.