Amphiregulin: a new growth factor in hepatocarcinogenesis.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Cancer Letters

• Publication date

  2007-08-28

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.CANLET.2007.01.015PMID 17321672
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Differential intracellular signalling induced by TGF-beta in rat adult hepatocytes and hepatoma cells: implications in liver carcinogenesis.

  2007cited by this paper
• EGFR-activated signaling and actin remodeling regulate cyclic stretch-induced NRF2-ARE activation.

  2007cited by this paper
• New molecular targets for hepatocellular carcinoma: the ErbB1 signaling system

  2007cited by this paper
• Correction for Substrate Selectivity of Epidermal Growth Factor-Receptor Ligand Sheddases and their Regulation by Phorbol Esters and Calcium Influx

  2006cited by this paper
• Genetics of hepatocellular tumors

  2006cited by this paper
• Impact of IGF‐1R/EGFR cross‐talks on hepatoma cell sensitivity to gefitinib

  2006cited by this paper
• Cell Communication and Signaling BioMed Central Review NOV story: the way to CCN3

  2006cited by this paper
• The Epidermal Growth Factor Receptor Pathway: A Model for Targeted Therapy

  2006cited by this paper
• Hypoxia induces epithelial amphiregulin gene expression in a CREB-dependent manner.

  2006cited by this paper
• Autocrine and Juxtacrine Effects of Amphiregulin on the Proliferative, Invasive, and Migratory Properties of Normal and Neoplastic Human Mammary Epithelial Cells*

  2006cited by this paper
• Blockade of IGF-1 receptor tyrosine kinase has antineoplastic effects in hepatocellular carcinoma cells.

  2006cited by this paper
• Cyclooxygenase-2 in hepatocellular carcinoma.

  2006cited by this paper
• Liver regeneration

  2006cited by this paper
• Amphiregulin contributes to the transformed phenotype of human hepatocellular carcinoma cells.

  2006cited by this paper
• Dysregulation of growth factor signaling in human hepatocellular carcinoma

  2006cited by this paper
• Amphiregulin as a tumor promoter for oral squamous cell carcinoma: involvement of cyclooxygenase 2.

  2006cited by this paper
• New therapies for hepatocellular carcinoma

  2006cited by this paper
• Epidermal growth factor receptor (EGFR) signaling in cancer.

  2006cited by this paper
• Control of ErbB signaling through metalloprotease mediated ectodomain shedding of EGF-like factors

  2006cited by this paper
• ADAMs as mediators of EGF receptor transactivation by G protein-coupled receptors.

  2006cited by this paper
• Autocrine, paracrine and juxtacrine signaling by EGFR ligands.

  2005cited by this paper
• Apoptosis: a mechanism of acute and chronic liver injury

  2005cited by this paper
• Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin

  2005cited by this paper
• Ligand-dependent activation of the epidermal growth factor receptor by secondary bile acids in polarizing colon cancer cells.

  2005cited by this paper
• Involvement of EGF receptor and c-Src in the survival signals induced by TGF-β1 in hepatocytes

  2005cited by this paper
• Cell death-induced activation of epidermal growth factor receptor in keratinocytes: implications for restricting epidermal damage in dermatitis.

  2005cited by this paper
• ADAMs: key components in EGFR signalling and development

  2005cited by this paper
• Hepatocellular carcinoma: molecular pathways and new therapeutic targets.

  2005cited by this paper
• Amphiregulin: an early trigger of liver regeneration in mice.

  2005cited by this paper
• Tobacco smoke stimulates the transcription of amphiregulin in human oral epithelial cells: evidence of a cyclic AMP-responsive element binding protein-dependent mechanism.

  2005cited by this paper
• Novel Role for Amphiregulin in Protection from Liver Injury*

  2005cited by this paper
• ADAM-mediated ectodomain shedding of HB-EGF in receptor cross-talk.

  2005cited by this paper
• Increases of amphiregulin and transforming growth factor-alpha in serum as predictors of poor response to gefitinib among patients with advanced non-small cell lung cancers.

  2005cited by this paper
• Gefitinib, an EGFR inhibitor, prevents hepatocellular carcinoma development in the rat liver with cirrhosis

  2005cited by this paper
• Defying death: the hepatocyte's survival kit.

  2004cited by this paper
• Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands

  2004cited by this paper
• The role of amphiregulin in breast cancer

  2004cited by this paper
• The mechanism of cleavage of EGFR ligands induced by inflammatory cytokines in gastric cancer cells.

  2004cited by this paper
• Src Family Kinases Mediate Epidermal Growth Factor Receptor Ligand Cleavage, Proliferation, and Invasion of Head and Neck Cancer Cells

  2004cited by this paper
• The epidermal growth factor-like growth factor amphiregulin is strongly induced by the adenosine 3',5'-monophosphate pathway in various cell types.

  2004cited by this paper
• Cannabinoids Induce Cancer Cell Proliferation via Tumor Necrosis Factor α-Converting Enzyme (TACE/ADAM17)-Mediated Transactivation of the Epidermal Growth Factor Receptor

  2004cited by this paper
• Amphiregulin expression in prostatic intraepithelial neoplasia and adenocarcinoma: A study of 93 cases

  2004cited by this paper
• Multiple G-protein-coupled receptor signals converge on the epidermal growth factor receptor to promote migration and invasion

  2004cited by this paper
• Liver regeneration: from myth to mechanism

  2004cited by this paper
• Prostaglandin E2 Synergistically Enhances Receptor Tyrosine Kinase-dependent Signaling System in Colon Cancer Cells*

  2004cited by this paper
• Heparin-binding Epidermal Growth Factor-like Growth Factor (HB-EGF) is a Mediator of Multiple Physiological and Pathological Pathways

  2004cited by this paper
• CHAPTER 41 – EGF family ligands

  2003cited by this paper
• Frequent epigenetic inactivation of the RASSF1A gene in hepatocellular carcinoma

  2003cited by this paper
• Expression of Wilms' tumor suppressor in the liver with cirrhosis: Relation to hepatocyte nuclear factor 4 and hepatocellular function

  2003cited by this paper
• EGF receptor ligands.

  2003cited by this paper
• Tobacco Smoke-induced Lung Cell Proliferation Mediated by Tumor Necrosis Factor α-converting Enzyme and Amphiregulin*

  2003cited by this paper
• TACE cleavage of proamphiregulin regulates GPCR‐induced proliferation and motility of cancer cells

  2003cited by this paper
• Mechanisms of human hepatocarcinogenesis.

  2003cited by this paper
• Prostaglandin E2 stimulates the growth of colon cancer cells via induction of amphiregulin.

  2003cited by this paper
• Inhibition of Apoptosis by Amphiregulin via an Insulin-like Growth Factor-1 Receptor-dependent Pathway in Non-small Cell Lung Cancer Cell Lines*

  2002cited by this paper
• Molecular pathogenesis of human hepatocellular carcinoma

  2002cited by this paper
• Diverse expression of ErbB receptor proteins during rat liver development and regeneration.

  2002cited by this paper
• Tumor necrosis factor-alpha converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability.

  2002cited by this paper
• Transgenic overexpression of amphiregulin induces a mitogenic response selectively in pancreatic duct cells.

  2002cited by this paper
• Transforming growth factor alpha, amphiregulin and cripto-1 are frequently expressed in advanced human ovarian carcinomas.

  2002cited by this paper
• Tumor Necrosis Factor- Converting Enzyme (TACE) Regulates Epidermal Growth Factor Receptor Ligand Availability*

  2002cited by this paper
• Hepatocytes convert to a fibroblastoid phenotype through the cooperation of TGF-beta1 and Ha-Ras: steps towards invasiveness.

  2002cited by this paper
• A subclass of HER1 ligands are prognostic markers for survival in bladder cancer patients.

  2001cited by this paper
• Untangling the ErbB signalling network

  2001cited by this paper
• The Wilms tumor suppressor WT1 encodes a transcriptional activator of amphiregulin.

  1999cited by this paper
• The epidermal growth factor receptor (EGFR) is an integral membrane tyrosine kinase that is activated upon binding of a family of polypeptides that includes epidermal growth factor (EGF), transforming growth factor-alpha (TGFα), amphiregulin (AR), heparin-binding EGF (HB-EGF),

  1999cited by this paper
• A Differential Requirement for the COOH-terminal Region of the Epidermal Growth Factor (EGF) Receptor in Amphiregulin and EGF Mitogenic Signaling*

  1999cited by this paper
• Expressions of epidermal growth factor family and its receptor in hepatocellular carcinoma cell lines: relationship to cell proliferation.

  1999cited by this paper
• Differential regulation of EGF-like growth factor genes in human keratinocytes.

  1999cited by this paper
• The ErbB-2/HER2 oncogenic receptor of adenocarcinomas: from orphanhood to multiple stromal ligands.

  1998cited by this paper
• Tyrosine Phosphorylation and Proteolysis

  1998cited by this paper
• Evaluation of epidermal growth factor-related growth factors and receptors and of neoangiogenesis in completely resected stage I-IIIA non-small-cell lung cancer: amphiregulin and microvessel count are independent prognostic indicators of survival.

  1998cited by this paper
• Cell Surface Ectodomain Cleavage of Human Amphiregulin Precursor Is Sensitive to a Metalloprotease Inhibitor

  1998cited by this paper
• The Epidermal Growth Factor Receptor Couples Transforming Growth Factor-α, Heparin-binding Epidermal Growth Factor-like Factor, and Amphiregulin to Neu, ErbB-3, and ErbB-4*

  1996cited by this paper
• STAT Activation by Epidermal Growth Factor (EGF) and Amphiregulin

  1996cited by this paper
• Interleukin 1 alpha and tumor necrosis factor alpha stimulate autocrine amphiregulin expression and proliferation of human papillomavirus-immortalized and carcinoma-derived cervical epithelial cells.

  1995cited by this paper
• Differential effects of a heparin antagonist (hexadimethrine) or chlorate on amphiregulin, basic fibroblast growth factor, and heparin‐binding EGF‐like growth factor activity

  1995cited by this paper
• Heparan sulfate is essential to amphiregulin-induced mitogenic signaling by the epidermal growth factor receptor.

  1994cited by this paper
• Induction and expression of amphiregulin in human pancreatic cancer.

  1994cited by this paper
• Auto- and cross-induction within the mammalian epidermal growth factor-related peptide family.

  1994cited by this paper
• Epidermal growth factor receptor-dependent stimulation of amphiregulin expression in androgen-stimulated human prostate cancer cells.

  1994cited by this paper
• The cytokine handbook

  1994cited by this paper
• Structure of heparin-binding EGF-like growth factor. Multiple forms, primary structure, and glycosylation of the mature protein.

  1992cited by this paper
• Autocrine action of amphiregulin in a colon carcinoma cell line and immunocytochemical localization of amphiregulin in human colon

  1992cited by this paper
• The interaction of amphiregulin with nuclei and putative nuclear localization sequence binding proteins.

  1992cited by this paper
• The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity

  1990cited by this paper
• Structure, expression and function of a schwannoma-derived growth factor

  1990cited by this paper
• Structure and function of human amphiregulin: a member of the epidermal growth factor family.

  1989cited by this paper
• Amphiregulin: a bifunctional growth-modulating glycoprotein produced by the phorbol 12-myristate 13-acetate-treated human breast adenocarcinoma cell line MCF-7.

  1988cited by this paper

• LPS-induced extracellular AREG triggers macrophage pyroptosis through the EGFR/TLR4 signaling pathway

  2025cites this paper
• Loss of Hepatocyte-Specific RECK Exacerbates Metabolic Dysfunction-Associated Steatohepatitis.

  2025cites this paper
• Reciprocal Paracrine Signaling and Dynamic Coordination of Transitional States in the Alveolar Epithelial Type 2 Cells and Associated Alveolar Lipofibroblasts During Homeostasis, Injury and Repair

  2025cites this paper
• Particulate matter facilitates amphiregulin-dependent lung cancer proliferation through glutamine metabolism

  2024cites this paper
• Dysregulated Treg repair responses lead to chronic rejection after heart transplantation

  2024cites this paper
• Hepatocellular RECK as a Critical Regulator of Metabolic Dysfunction-associated Steatohepatitis Development

  2024cites this paper
• Amphiregulin in infectious diseases: Role, mechanism, and potential therapeutic targets.

  2023cites this paper
• Dimethylarsinic acid induces bladder carcinogenesis via the amphiregulin pathway.

  2023cites this paper
• Cytokines secreted by mesenchymal stem cells reduce demyelination in an animal model of Charcot-Marie-Tooth disease.

  2022cites this paper
• SLU7: A New Hub of Gene Expression Regulation—From Epigenetics to Protein Stability in Health and Disease

  2022cites this paper
• Amphiregulin Supplementation During Pig Oocyte In Vitro Maturation Enhances Subsequent Development of Cloned Embryos by Promoting Cumulus Cell Proliferation

  2022cites this paper
• Hippo-YAP signaling in digestive system tumors.

  2021cites this paper
• Estrogens in Hepatocellular Carcinoma: Friends or Foes?

  2021cites this paper
• Expression of Amphiregulin in Enchondromas and Central Chondrosarcomas

  2021cites this paper
• Upregulation of amphiregulin by retinoic acid and Wnt signalling promotes liver cancer cell proliferation

  2020cites this paper
• Type 2 Innate Lymphoid Cells in Liver and Gut: From Current Knowledge to Future Perspectives

  2019cites this paper
• Dickkopf-1 and Amphiregulin as Novel Biomarkers and Potential Therapeutic Targets in Hepatocellular Carcinoma

  2019cites this paper
• Secreted amphiregulin promotes vincristine resistance in oral squamous cell carcinoma.

  2019cites this paper
• Valproic acid-induced amphiregulin secretion confers resistance to temozolomide treatment in human glioma cells

  2019cites this paper
• Calcium Regulates HCC Proliferation as well as EGFR Recycling/Degradation and Could Be a New Therapeutic Target in HCC

  2019cites this paper
• Gene expression profiling of spontaneously occurring canine mammary tumours: Insight into gene networks and pathways linked to cancer pathogenesis

  2018cites this paper
• Differential effects of epidermal growth factor (EGF) receptor ligands on receptor binding, downstream signalling pathways and DNA synthesis in hepatocytes

  2017cites this paper
• Merlin, the product of NF2 gene, is associated with aromatase expression and estrogen formation in human liver tissues and liver cancer cells.

  2017cites this paper
• Positive Mediators of Cell Proliferation in Neoplasia: Growth Factors and Receptors

  2017cites this paper
• Expression and Function of the Epidermal Growth Factor Receptor in Physiology and Disease.

  2016cites this paper
• Amphiregulin Confers Regulatory T Cell Suppressive Function and Tumor Invasion via the EGFR/GSK-3β/Foxp3 Axis*

  2016cites this paper
• Growth Regulation in Hepatobiliary Cancer: Involvement of Growth Factors

  2016cites this paper
• Furan-induced transcriptomic and gene-specific DNA methylation changes in the livers of Fischer 344 rats in a 2-year carcinogenicity study

  2016cites this paper
• Immunological Microenvironment of Hepatocellular Carcinoma and Its Clinical Implication

  2016cites this paper
• Amphiregulin enhances alpha6beta1 integrin expression and cell motility in human chondrosarcoma cells through Ras/Raf/MEK/ERK/AP-1 pathway

  2015cites this paper
• Loss of hepatocyte ERBB3 but not EGFR impairs hepatocarcinogenesis.

  2015cites this paper
• Amphiregulin activates human hepatic stellate cells and is upregulated in non alcoholic steatohepatitis

  2015cites this paper
• Immunological landscape and immunotherapy of hepatocellular carcinoma

  2015cites this paper
• Amphiregulin activates regulatory T lymphocytes and suppresses CD8+ T cell-mediated anti-tumor response in hepatocellular carcinoma cells

  2015cites this paper
• Expression and Clinical Significance of YAP, TAZ, and AREG in Hepatocellular Carcinoma

  2014cites this paper
• HER2/neu: an increasingly important therapeutic target. Part 2: Distribution of HER2/neu overexpression and gene amplification by organ, tumor site and histology

  2014cites this paper
• Amphiregulin.

  2014cites this paper
• Part 2 : Distribution of HER 2 / neu overexpression and gene amplification by organ , tumor site and histology

  2014cites this paper
• The EGFR signalling system in the liver: from hepatoprotection to hepatocarcinogenesis

  2013cites this paper
• RASSF1A-Mediated Regulation of AREG via the Hippo Pathway in Hepatocellular Carcinoma

  2013cites this paper
• Oncogenes and Tumor Suppressors RASSF 1 A-Mediated Regulation of AREG via the Hippo Pathway in Hepatocellular Carcinoma

  2013cites this paper
• Angiogenic factors in bone local environment.

  2013cites this paper
• Pituitary protein 7B2 plasma levels in patients with liver disease: Comparisons with other hormones and neuropeptides

  2013cites this paper
• Regulation of Amphiregulin Gene Expression by β-Catenin Signaling in Human Hepatocellular Carcinoma Cells: A Novel Crosstalk between FGF19 and the EGFR System

  2012cites this paper
• SEX STEROID METABOLISM AND ACTION, INFLAMMATION AND PROSTATE CANCER: HYPOTHETICAL MECHANISMS AND NETWORKS

  2012cites this paper
• Amphiregulin Stimulates Liver Regeneration After Small‐for‐Size Mouse Liver Transplantation

  2012cites this paper
• Role Of Thromboxane Receptor-Alpha In Prostate Cancer Progression

  2012cites this paper
• Identification of Sumoylation Sites in CCDC6, the First Identified RET Partner Gene in Papillary Thyroid Carcinoma, Uncovers a Mode of Regulating CCDC6 Function on CREB1 Transcriptional Activity

  2012cites this paper
• Deregulation of signalling pathways in prognostic subtypes of hepatocellular carcinoma: novel insights from interspecies comparison.

  2012cites this paper
• Signal Transduction of Hepatocellular Carcinoma

  2012cites this paper
• Reactive oxygen species alter autocrine and paracrine signaling.

  2011cites this paper
• Neisseria gonorrhoeae Infection Induces Altered Amphiregulin Processing and Release

  2011influential citation
• Epidermal Growth Factor Receptor (EGFR) Crosstalks in Liver Cancer

  2011influential citation
• Quantitative genetic study of amphiregulin and fractalkine circulating levels--potential markers of arthropathies.

  2011cites this paper
• The EGFR Ligands Amphiregulin and Heparin-Binding EGF-like Growth Factor Promote Peritoneal Carcinomatosis in CXCR4-Expressing Gastric Cancer

  2011cites this paper
• ADAM metallopeptidase domain 17 (ADAM17) is naturally processed through major histocompatibility complex (MHC) class I molecules and is a potential immunotherapeutic target in breast, ovarian and prostate cancers

  2011cites this paper
• in CXCR 4-Expressing Gastric Cancer EGF-like Growth Factor Promote Peritoneal Carcinomatosis The EGFR Ligands Amphiregulin and Heparin-Binding

  2011cites this paper
• Lung Tumor-Associated Dendritic Cell-Derived Amphiregulin Increased Cancer Progression

  2011cites this paper
• AREG (amphiregulin (schwannoma -derived growth factor))

  2011cites this paper
• The multiple roles of amphiregulin in human cancer.

  2011cites this paper
• Suppression of amphiregulin/epidermal growth factor receptor signals contributes to the protective effects of quercetin in cirrhotic rats.

  2011cites this paper
• Technical‐grade perfluorooctane sulfonate alters the expression of more transcripts in cultured chicken embryonic hepatocytes than linear perfluorooctane sulfonate

  2011cites this paper
• Estrogen signalling through amphiregulin may be implicated in human hepatocellular carcinoma

  2011cites this paper
• Amphiregulin level in patients with psoriasis before and after photochemotherapy and its pathogenic role in psoriasis

  2011cites this paper
• The Effects of Perfluoroalkyl Compounds on In Ovo Toxicity and Hepatic mRNA Expression in the Domestic Chicken (Gallus gallus domesticus)

  2011cites this paper
• Growth Factors and Their Receptors in Cell Differentiation, Cancer and Cancer Therapy

  2011cites this paper
• Hepatitis C virus infection induces the expression of amphiregulin, a factor related to the activation of cellular survival pathways and required for efficient viral assembly.

  2011cites this paper
• Progression CancerCell-Derived Amphiregulin Increased Lung Tumor-Associated Dendritic

  2011cites this paper
• Suppression of Amphiregulin/Epidermal Growth Factor Receptor Signals Contributes to the Protective Effects of Quercetin in

  2011cites this paper
• BRCA1 represses amphiregulin gene expression.

  2010influential citation
• Plasma transforming growth factor alpha and amphiregulin protein levels in NCIC Clinical Trials Group BR.21.

  2010cites this paper
• Molecular characterization of aromatase inhibitor-resistant, tamoxifen-resistant and LTEDaro cell lines.

  2010cites this paper
• ATP confers tumorigenic properties to dendritic cells by inducing amphiregulin secretion.

  2010cites this paper
• Molecular analysis of tumor-promoting CD8+ T cells in two-stage cutaneous chemical carcinogenesis.

  2010cites this paper
• CCDC6 represses CREB1 activity by recruiting histone deacetylase 1 and protein phosphatase 1

  2010cites this paper
• Molecular Analysis of Tumor-Promoting CD8 þ T Cells in Two-Stage Cutaneous Chemical

  2010cites this paper
• Impairment of pre-mRNA splicing in liver disease: mechanisms and consequences.

  2010cites this paper
• The Epidermal Growth Factor Receptor: A Link Between Inflammation and Liver Cancer

  2009cites this paper
• EGF receptor as a drug target in arterial hypertension.

  2009cites this paper
• Amphiregulin is a factor for resistance of glioma cells to cannabinoid‐induced apoptosis

  2009influential citation
• Epidermal growth factor receptor ligands in murine models for erythropoietic protoporphyria: potential novel players in the progression of liver injury.

  2009cites this paper
• Tumorigenicity of cortical astrocyte cell line induced by the protease ADAM17

  2009cites this paper
• Mitochondrial dysfunction-induced amphiregulin upregulation mediates chemo-resistance and cell migration in HepG2 cells

  2009cites this paper
• Aromatase in Nontumoral and Malignant Human Liver Tissues and Cells

  2009cites this paper
• Aromatase and Amphiregulin Are Correspondingly Expressed in Human Liver Cancer Cells

  2009cites this paper
• Nuevos mecanismos en la defensa natural del hígado frente a la lesión

  2009cites this paper
• Inflammation and Liver Cancer

  2009cites this paper
• Evaluation of in vitro cytotoxicity and paracellular permeability of intact monolayers with mouse embryonic stem cells.

  2008cites this paper
• Therapeutic targeting of g-protein coupled receptor-mediated epidermal growth factor receptor transactivation in human glioma brain tumors.

  2008cites this paper
• The role of amphiregulin in exemestane-resistant breast cancer cells: evidence of an autocrine loop.

  2008influential citation
• Investigations into the Role of Protein Phosphatases in the EGFR Signaling Network

  2008cites this paper
• Rôle de l'amphiréguline dans la résistance du cancer du poumon non-à petites cellules au gefitinib

  2008cites this paper
• Role of epidermal growth factor receptor in the pathogenesis and treatment of arterial hypertension

  2007cites this paper
• Dissection of signal transduction pathways as a tool for the development of targeted therapies of hepatocellular carcinoma.

  2007cites this paper