Promoting increased mechanical properties of tissue engineered neocartilage via the application of hyperosmolarity and 4α-phorbol 12,13-didecanoate (4αPDD).

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Journal of Biomechanics

• Publication date

  2014-11-28

• Fields of study

  Medicine, Materials Science, Chemistry, Engineering

• Identifiers
  DOI 10.1016/j.jbiomech.2014.09.018PMID 25442009PMCID PMC5107315
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading

  2014cited by this paper
• TRPV4 channel activation improves the tensile properties of self-assembled articular cartilage constructs.

  2013cited by this paper
• Enhancing Post-Expansion Chondrogenic Potential of Costochondral Cells in Self-Assembled Neocartilage

  2013cited by this paper
• Applied osmotic loading for promoting development of engineered cartilage.

  2013influential reference
• Hypoxia-induced collagen crosslinking as a mechanism for enhancing mechanical properties of engineered articular cartilage.

  2013cited by this paper
• Using changes in hydrostatic and osmotic pressure to manipulate metabolic function in chondrocytes.

  2011cited by this paper
• Effects of Hypertonic (NaCl) Two-Dimensional and Three-Dimensional Culture Conditions on the Properties of Cartilage Tissue Engineered from an Expanded Mature Bovine Chondrocyte Source

  2011cited by this paper
• The Wisdom of the Body; A Contemporary View

  2010cited by this paper
• The sixth sense of the musculoskeletal system

  2010cited by this paper
• Chondroprotective role of the osmotically sensitive ion channel transient receptor potential vanilloid 4: age- and sex-dependent progression of osteoarthritis in Trpv4-deficient mice.

  2010cited by this paper
• Intracellular Na(+) and Ca(2+) modulation increases the tensile properties of developing engineered articular cartilage.

  2010cited by this paper
• Transient receptor potential vanilloid 4

  2010cited by this paper
• Dynamic loading stimulates chondrocyte biosynthesis when encapsulated in charged hydrogels prepared from poly(ethylene glycol) and chondroitin sulfate.

  2010cited by this paper
• The Emerging Chondrocyte Channelome

  2010cited by this paper
• The effects of osmotic stress on the structure and function of the cell nucleus

  2009cited by this paper
• Hyperosmolarity regulates SOX9 mRNA posttranscriptionally in human articular chondrocytes

  2009cited by this paper
• Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes.

  2009cited by this paper
• Effects of Temporal Hydrostatic Pressure on Tissue-Engineered Bovine Articular Cartilage Constructs

  2008influential reference
• Matrix Development in Self-Assembly of Articular Cartilage

  2008cited by this paper
• Depth-dependent analysis of the role of collagen fibrils, fixed charges and fluid in the pericellular matrix of articular cartilage on chondrocyte mechanics.

  2008cited by this paper
• Dependence of Zonal Chondrocyte Water Transport Properties on Osmotic Environment

  2008cited by this paper
• Functional Gene Screening System Identified TRPV4 as a Regulator of Chondrogenic Differentiation*

  2007cited by this paper
• Changes in intracellular calcium concentration in response to hypertonicity in bovine articular chondrocytes.

  2004cited by this paper
• Abnormal osmotic regulation in trpv4-/- mice

  2003cited by this paper
• Hyper-osmotic stress induces volume change and calcium transients in chondrocytes by transmembrane, phospholipid, and G-protein pathways.

  2001cited by this paper
• Time-dependent aggrecan gene expression of articular chondrocytes in response to hyperosmotic loading.

  2001cited by this paper
• Depth-dependent compressive properties of normal aged human femoral head articular cartilage: relationship to fixed charge density.

  2001cited by this paper
• A hyperosmotic stimulus regulates intracellular pH, calcium, and S-100 protein levels in avian chondrocytes.

  1996cited by this paper
• Regulation of matrix synthesis rates by the ionic and osmotic environment of articular chondrocytes

  1993cited by this paper
• Biphasic indentation of articular cartilage--II. A numerical algorithm and an experimental study.

  1989cited by this paper
• A Study of Ionic Equilibria in Cartilage

  1972cited by this paper
• The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid.

  1961cited by this paper

• Organic solvents enhance polyvinyl alcohol/polyethylene glycol self‐healing hydrogels for artificial cartilage

  2022cites this paper
• Transient receptor potential vanilloid 4 as a regulator of induced pluripotent stem cell chondrogenesis

  2021cites this paper
• Activation of Transient Receptor Potential Vanilloid (TRPV) 4 as a Therapeutic Strategy in Osteoarthritis.

  2019cites this paper
• Challenges in Fabrication of Tissue-Engineered Cartilage with Correct Cellular Colonization and Extracellular Matrix Assembly

  2018cites this paper
• Tissue Engineering Strategies for Cartilage Repair

  2017cites this paper
• Tension stimulation drives tissue formation in scaffold-free systems

  2017cites this paper
• TRPV4: Molecular Conductor of a Diverse Orchestra.

  2016cites this paper
• Coupling Freshly Isolated CD44+ Infrapatellar Fat Pad‐Derived Stromal Cells with a TGF‐β3 Eluting Cartilage ECM‐Derived Scaffold as a Single‐Stage Strategy for Promoting Chondrogenesis

  2015cites this paper